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IKBKAP (human)

Overview IKBKAP May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; Protein kinase, regulatory subunit; Transcription regulation Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; DNA-directed RNA polymerase II, holoenzyme Molecular Function: signal transducer activity; protein binding; DNA binding; phosphorylase kinase regulator activity; ATP binding; protein kinase activity Biological Process: regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter; protein complex assembly; immune response; I-kappaB phosphorylation; protein amino acid phosphorylation; positive regulation of cell migration Reference #:  O95163 (UniProtKB) Alt. Names/Synonyms: DKFZp781H1425; DYS; Elongator complex protein 1; ELP1; FD; FLJ12497; IKAP; IkappaB kinase complex-associated protein; IKBKAP; IKI3; IKK complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; p150; TOT1 Gene Symbols: IKBKAP Molecular weight: 150,254 Da Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IKBKAP

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 223900 603722  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S471-p	KLGAVGGsGFKVCLR
0	1		T654	YDEFLLLTTHSHTCQ
0	1		S695-p	LRKVERGsRIVtVVP
0	1		T699-p	ERGsRIVtVVPQDtK
0	2		T705-p	VtVVPQDtKLVLQMP
0	1		K735-u	QIRKWLDkLMFKEAF
0	1		S803-p	MYPAPVTsSVyLSRD
0	1		Y806-p	APVTsSVyLSRDPDG
0	1		S842-p	YCLSILTsHVKKTTP
0	2		S867-p	ELQGNAPsDPDAVSA
0	1		T935-p	ETNYQRFtIDKYLKR
0	1		S1171-p	DLFSETSsVVsGSEM
0	1		S1174-p	SETSsVVsGSEMSGK
0	2		S1190-p	SHSNSRIsARSSKNR

	mouse
N469	KLGAVGGNGFKVPLT
T655-p	CDDFLLVtTHSHTCQ
S696	LRKVERGSRIVTVVP
T700	ERGSRIVTVVPQDTK
T706	VTVVPQDTKLILQMP
K736	QIRKWLDKLMFKEAF
K804	MYPPPITKSVQVSTH
Q807	PPITKSVQVSTHPDG
S843	FCLSILTSHVKKTTP
F868	ELQGNLPFDPESVSV
T936	ETNYQRFTIDKYLKR
S1172	DLFSETSSIMSGSEM
S1175	SETSSIMSGSEMSGR
S1191	SHSNSRISARSSKNR

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