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Protein Page:
IKBKAP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IKBKAP May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation; Protein kinase, regulatory subunit
Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; DNA-directed RNA polymerase II, holoenzyme
Molecular Function: protein binding; signal transducer activity; DNA binding; phosphorylase kinase regulator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; protein complex assembly; immune response; regulation of protein kinase activity; signal transduction; protein amino acid phosphorylation; positive regulation of cell migration
Reference #:  O95163 (UniProtKB)
Alt. Names/Synonyms: DKFZp781H1425; DYS; Elongator complex protein 1; ELP1; FD; FLJ12497; IKAP; IkappaB kinase complex-associated protein; IKBKAP; IKI3; IKK complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; p150; TOT1
Gene Symbols: IKBKAP
Molecular weight: 150,254 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKBKAP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S173-p KETQFHGsEGRQAAF
0 1 S251-p LAWKPSGsLIASTQD
0 4 S471-p KLGAVGGsGFKVCLR
0 1 T654 YDEFLLLTTHSHTCQ
0 1 S695-p LRKVERGsRIVtVVP
0 1 T699-p ERGsRIVtVVPQDtK
0 2 T705-p VtVVPQDtKLVLQMP
0 1 K735-ub QIRKWLDkLMFKEAF
0 2 S803-p MYPAPVTssVyLSRD
0 1 S804-p YPAPVTssVyLSRDP
0 1 Y806-p APVTssVyLSRDPDG
0 1 S842-p YCLSILTsHVKKTTP
0 5 S867-p ELQGNAPsDPDAVSA
0 1 T935-p ETNYQRFtIDKYLKR
0 1 S1171-p DLFSETSsVVsGSEM
0 2 S1174-p SETSsVVsGSEMSGK
0 2 S1190-p SHSNSRIsARSSKNR
0 1 S1211-p KHSLKEGsPLEDLAL
0 1 A1283 LTYQQNSATPVLGPN
0 1 T1292 PVLGPNSTANSIMAS
  mouse

 
S173 KQTQFHGSEGRPTAF
S251 LAWKPSGSLIASTQD
N469 KLGAVGGNGFKVPLT
T655-p CDDFLLVtTHSHTCQ
S696 LRKVERGSRIVTVVP
T700 ERGSRIVTVVPQDTK
T706 VTVVPQDTKLILQMP
K736 QIRKWLDKLMFKEAF
K804 MYPPPITKSVQVSTH
S805 YPPPITKSVQVSTHP
Q807 PPITKSVQVSTHPDG
S843 FCLSILTSHVKKTTP
F868 ELQGNLPFDPESVSV
T936 ETNYQRFTIDKYLKR
S1172 DLFSETSSIMSGSEM
S1175 SETSSIMSGSEMSGR
S1191 SHSNSRISARSSKNR
S1212 KHSLKEGSPLEGLAL
T1284-p PAGQQSStTPVLGPS
T1293-p PVLGPSStANSITAS
  rat

 
S173 KDTQFHGSEGRPITF
S251 LAWKPSGSLIASTQD
T469 KLGAVGGTGFKVPLR
T653 CDDFLLVTTHSHTCQ
S694 LRKVERGSRIVTVVP
T698 ERGSRIVTVVPQDTK
T704 VTVVPQDTKLILQMP
K734 QIRKWLDKLMFKEAF
K802 MYPPPVTKSVQVSTN
S803 YPPPVTKSVQVSTNP
Q805 PPVTKSVQVSTNPDG
S841 FCLSILTSHVKKTTP
F866 ELQGKIPFVPESVSA
T934 ETNYQRFTIDKYLKR
S1170 DLFSETSSIRSGSEM
S1173 SETSSIRSGSEMSGR
S1189 SHSNSRISARSSKNR
S1210 KHSLKEGSPLEGLAL
S1282 LTGQQSSSTPVLGPS
T1291 PVLGPSSTVNSIMAS
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