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Protein Page:
PTPN20A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PTPN20A Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. 15 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Cancer Testis Antigen (CTA)
Cellular Component: microtubule; microtubule organizing center; nucleus
Molecular Function: protein tyrosine phosphatase activity
Reference #:  Q4JDL3 (UniProtKB)
Alt. Names/Synonyms: bA142I17.1; CT 126; hPTPN20; MGC142033; protein tyrosine phosphatase, non-receptor type 20A; PTN20; PTPN20A; PTPN20B; Tyrosine-protein phosphatase non-receptor type 20
Gene Symbols: PTPN20A
Molecular weight: 48,423 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below

PTPN20A
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K55 KVNSEKVKLSLRNFP
0 1 D65 LRNFPHNDYEDVFEE
0 2 S95-p PFRRDRWsSEDEEAA
0 1 S96 FRRDRWsSEDEEAAG
0 2 S105-p DEEAAGPsQALsPLL
0 1 S109-p AGPsQALsPLLsDTR
0 1 S113-p QALsPLLsDTRKIVs
0 1 K117 PLLsDTRKIVsEGEL
0 2 S120-p sDTRKIVsEGELDQL
0 1 K169-a EFMALELkNLPGEFN
  mouse

 
K55-a KMNSENVkPSHHLSF
K65-a HHLSFSDkYELVYPE
N95 RSLRNRWNSMDSETA
S96 SLRNRWNSMDSETAG
S105 DSETAGPSKTVSPVL
S109 AGPSKTVSPVLSGSS
S113 KTVSPVLSGSSRLSK
T124 RLSKDTETSVSEKEL
S127 KDTETSVSEKELTQL
M175 EFLELEQMTLPDDFN
  rat

 
K55 KVNSESVKTSHHMSF
K65 HHMSFSNKYDLVFPE
S95-p LSHRNRWssVDPESA
S96-p SHRNRWssVDPESAG
S105 DPESAGPSKTVSTVL
S109 AGPSKTVSTVLSESS
S113 KTVSTVLSESSTDtA
T119-p LSESSTDtAVsEREL
S122-p SSTDtAVsERELTQL
M170 EFLELEEMIPPDDFK
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