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Protein Page:
IRAK3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IRAK3 a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; IRAK family
Cellular Component: cytoplasm; nucleus
Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding
Biological Process: negative regulation of MAP kinase activity; negative regulation of interleukin-12 production; regulation of protein complex disassembly; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; negative regulation of interleukin-6 production; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly
Reference #:  Q9Y616 (UniProtKB)
Alt. Names/Synonyms: ASRT5; FLJ13601; IL-1 receptor-associated kinase M; Interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase M; IRAK-3; IRAK-M; IRAK3; IRAKM
Gene Symbols: IRAK3
Molecular weight: 67,767 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IRAK3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S51 LAERLSSSWLDVRHI
0 1 S110-p TNYGAVLsPSEKSYQ
0 1 S154-p ILLKSSIsFQNIIEG
0 1 T162-p FQNIIEGtRNFHKDF
0 1 T188-p RVEIQNLtyAVKLFK
0 1 Y189-p VEIQNLtyAVKLFKQ
0 1 K199-ac KLFKQEKkMQCKKHW
0 1 K379-ub RVVLDDPkHIQLRDL
0 1 S398-p MEKRGLDsCLsFLDK
0 1 S401-p RGLDsCLsFLDKKVP
0 2 S467-p LKSFRCPsPLFLENV
0 1 S484-p IPVEDDEsQNNNLLP
0 1 S510-p QKTPFECsQsEVMFL
0 1 S512-p TPFECsQsEVMFLSL
0 1 D588 CSSKFSWDEYEQYKK
  mouse

 
S51-p LAERLSNsWLDVRHI
T110 INYGVSWTPSVQTHH
S167 TLQKTPISFQSILEG
T175 FQSILEGTKHFHKDF
A201 RVDIRNQAYAVKLFK
Y202 VDIRNQAYAVKLFKQ
K212 KLFKQEKKMQLKKHW
K392 KVVLDDPKHVQLRDL
S411 MEKRGLDSCLSFLDR
S414 RGLDSCLSFLDRKIP
S480-p LKSFRCPsPLFLDNV
N497 IPVEDDENQNNHSVP
S523 QKTPFECSQSEVTFL
S525 TPFECSQSEVTFLGL
S601-p CSSGLFCsEHEQSKK
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