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FIS1 (human)

Overview FIS1 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Mitochondrial Cellular Component: integral to peroxisomal membrane; protein complex; mitochondrion; peroxisome; integral to mitochondrial outer membrane Molecular Function: identical protein binding; protein binding; receptor binding Biological Process: peroxisome fission; mitochondrial fission; release of cytochrome c from mitochondria; elevation of cytosolic calcium ion concentration; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration Reference #:  Q9Y3D6 (UniProtKB) Alt. Names/Synonyms: CGI-135; FIS1; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11 Gene Symbols: FIS1 Molecular weight: 16,938 Da Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states

Select Structure to View Below FIS1 1NZN - A=1-123 (human) 1PC2 - A=1-145 (human) 1IYG - A=1-122 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1NZN 1PC2  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K20	DLLKFEKKFQSEkAA
0	5		K25-u	EKKFQSEkAAGSVsK
0	1		S29	QSEkAAGSVsKSTQF
0	1		S31-p	EkAAGSVsKSTQFEY
0	1		S45	YAWCLVRSKYNDDIR
0	1		Y47	WCLVRSKYNDDIRkG
0	2		K53-u	KYNDDIRkGIVLLEE
0	1		-	gap
0	1		K64	LLEELLPKGSKEEQR
0	1		Y76-p	EQRDYVFyLAVGNyR
0	1		Y82-p	FyLAVGNyRLKEyEK
0	1		Y87-p	GNyRLKEyEKALKyV
0	1		Y93-p	EyEKALKyVRGLLQT
0	1		K108	EPQNNQAKELERLID

	FIS1 iso3
K20	DLLKFEKKFQSEKAA
K25	EKKFQSEKAAGSVSK
S29	QSEKAAGSVSKSTQF
S31	EKAAGSVSKSTQFEY
T45-p	YAWCLVRtRyNDDIR
Y47-p	WCLVRtRyNDDIRKG
K53	RyNDDIRKGIVLLEE
-	gap
K64	LLEELLPKGSKEEQR
Y76	EQRDYVFYLAVGNYR
Y82	FYLAVGNYRLKEYEK
Y87	GNYRLKEYEKALKYV
Y93	EYEKALKYVRGLLQT
K108	EPQNNQAKELERLID

	mouse ► Hide Isoforms
K20-u	DLKNFERkFQSEQAA
Q25	ERkFQSEQAAGsVSK
S29-p	QSEQAAGsVSKSTQF
S31	EQAAGsVSKSTQFEY
S45	YAWCLVRSKYNEDIR
Y47	WCLVRSKYNEDIRRG
R53	KYNEDIRRGIVLLEE
-	gap
K64-u	LLEELLPkGSKEEQR
Y76	EQRDYVFYLAVGNYR
Y82	FYLAVGNYRLKEYEK
Y87	GNYRLKEYEKALKYV
Y93	EYEKALKYVRGLLQT
K108-u	EPQNNQAkELERLID

	FIS1 iso4
-	gap
-	gap
-	under review
-	gap
-	gap
-	gap
-	gap
K9-u	DAQRRSCkELLPKGS
K14	SCkELLPKGSKEEQR
Y26	EQRDYVFYLAVGNYR
Y32	FYLAVGNYRLKEYEK
Y37	GNYRLKEYEKALKYV
Y43	EYEKALKYVRGLLQT
K58	EPQNNQAKELERLID

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