Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to peroxisomal membrane; protein complex; mitochondrion; membrane; peroxisome; integral to mitochondrial outer membrane
Molecular Function: protein binding; receptor binding
Biological Process: peroxisome fission; mitochondrial fission; release of cytochrome c from mitochondria; elevation of cytosolic calcium ion concentration; mitochondrial fusion; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.