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Protein Page:
FIS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FIS1 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to peroxisomal membrane; protein complex; mitochondrion; membrane; peroxisome; integral to mitochondrial outer membrane
Molecular Function: protein binding; receptor binding
Biological Process: peroxisome fission; mitochondrial fission; elevation of cytosolic calcium ion concentration; release of cytochrome c from mitochondria; mitochondrial fusion; reduction of endoplasmic reticulum calcium ion concentration; mitochondrion degradation; positive regulation of caspase activity; mitochondrial fragmentation during apoptosis; protein targeting to mitochondrion; protein homooligomerization; elevation of mitochondrial calcium ion concentration
Reference #:  Q9Y3D6 (UniProtKB)
Alt. Names/Synonyms: CGI-135; FIS1; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11
Gene Symbols: FIS1
Molecular weight: 16,938 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below

FIS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p AVLNELVsVEDLLKF
0 1 K20 DLLKFEKKFQSEkAA
0 5 K25-ub EKKFQSEkAAGSVsK
0 1 S29 QSEkAAGSVsKSTQF
0 1 S31-p EkAAGSVsKSTQFEY
0 1 K46 AWCLVRSKYNDDIRk
0 2 K53-ub KYNDDIRkGIVLLEE
0 1 - gap
0 1 K64 LLEELLPKGSKEEQR
0 1 Y76-p EQRDYVFyLAVGNyR
0 1 Y82-p FyLAVGNyRLKEyEK
0 1 Y87-p GNyRLKEyEKALKyV
0 1 Y93-p EyEKALKyVRGLLQT
0 1 K108 EPQNNQAKELERLID
  mouse

► Hide Isoforms
 
S10 AVLNELVSVEDLKNF
K20-ub DLKNFERkFQSEQAA
Q25 ERkFQSEQAAGsVSK
S29-p QSEQAAGsVSKSTQF
S31 EQAAGsVSKSTQFEY
K46-ac AWCLVRSkYNEDIRR
R53 kYNEDIRRGIVLLEE
- gap
K64-ub LLEELLPkGSKEEQR
Y76 EQRDYVFYLAVGNYR
Y82 FYLAVGNYRLKEYEK
Y87 GNYRLKEYEKALKYV
Y93 EYEKALKYVRGLLQT
K108-ub EPQNNQAkELERLID
  FIS1 iso4  
- under review  
- gap
- gap
- gap
- gap
- gap
- gap
K9-ub DAQRRSCkELLPKGS
K14 SCkELLPKGSKEEQR
Y26 EQRDYVFYLAVGNYR
Y32 FYLAVGNYRLKEYEK
Y37 GNYRLKEYEKALKYV
Y43 EYEKALKYVRGLLQT
K58 EPQNNQAKELERLID
  rat

 
S10 AVLNELVSVEDLKNF
K20 DLKNFERKFQSEQAA
Q25 ERKFQSEQAAGSVSK
S29 QSEQAAGSVSKSTQF
S31 EQAAGSVSKSTQFEY
K46 AWCLVRSKYNDDIRR
R53 KYNDDIRRGIVLLEE
- under review  
K64 LLEELLPKGSKEEQR
Y76 EQRDYVFYLAVGNYR
Y82 FYLAVGNYRLKEYEK
Y87 GNYRLKEYEKALKYV
Y93 EYEKALKYVRGLLQT
K108 EPQNNQAKELERLID
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