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Protein Page:
WASF3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WASF3 Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: cytoskeleton; lamellipodium; cytoplasm
Molecular Function: actin binding
Biological Process: lamellipodium biogenesis; positive regulation of myelination; regulation of cell shape; actin filament polymerization; cytoskeleton organization and biogenesis; protein complex assembly; oligodendrocyte development
Reference #:  Q9UPY6 (UniProtKB)
Alt. Names/Synonyms: Brush-1; KIAA0900; Protein WAVE-3; SCAR3; Verprolin homology domain-containing protein 3; WAS protein family, member 3; WASF3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; WAVE3; Wiskott-Aldrich syndrome protein family member 3
Gene Symbols: WASF3
Molecular weight: 55,293 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WASF3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R6 __MPLVKRNIEPRHL
0 1 R39 STLAAIIRQLSSLSK
0 1 S68 NFYIRANSLQDRIDR
1 0 Y151-p KKDGLKFyTDPSyFF
0 3 Y156-p KFyTDPSyFFDLWkE
0 3 K162-ub SyFFDLWkEKMLQDt
0 1 T169-p kEKMLQDtEDKRKEK
0 1 K183 KRRQKEQKRIDGTTR
0 1 K193 DGTTREVKKVRKARN
0 9 Y225-p NRLSQSVyHGASSEG
0 1 S229 QSVyHGASSEGSLsP
0 1 S230 SVyHGASSEGSLsPD
0 2 S233 HGASSEGSLsPDTRS
0 3 S235-p ASSEGSLsPDTRSHA
1 0 Y248-p HASDVTDySYPATPN
0 1 Y286-p SQAAEHEyRPPSASA
1 0 Y337-p LPAQIIEyYNPSGPP
0 1 K466 EQREQEAKREPVGND
1 0 Y486-p SRRIAVEySDSDDDS
  mouse

 
R6-m1 __MPLVKrNIEPRHL
R39-m1 STLAAIIrQLSSLSK
S68-p NFYIRANsLQDRIDR
Y151 KKDGLKFYTDPSYFF
Y156 KFYTDPSYFFDLWkE
K162-ub SYFFDLWkEKMLQDT
T169 kEKMLQDTEDKRKEK
K183-ac KRRQKEQkRVDGTTR
K193-ac DGTTREVkKVRKARN
H225 NRLSQSVHHGAssEG
S229-p QSVHHGAssEGsLsP
S230-p SVHHGAssEGsLsPD
S233-p HGAssEGsLsPDTRS
S235-p AssEGsLsPDTRSHT
Y248 HTSDVTDYSYPATPN
Y286 NQGAEHEYRPSSASA
Y337 LPAQIIEYYSPSGPP
K465-ub EQREQEAkREPVGND
Y485 SRRIAVEYSDSDDDS
  rat

 
R6 __MPLVKRNIEPRHL
R39 STLAAIIRQLSSLSK
S68 NFYIRANSLQDRIDR
- under review  
- under review  
- under review  
- under review  
K182 PRRRQEQKRVDGTTR
K192 DGTTREVKKVRKARN
H224 NRLSQSVHHGASSEG
S228 QSVHHGASSEGSLSP
S229 SVHHGASSEGSLSPD
S232 HGASSEGSLSPDTRS
S234 ASSEGSLSPDTRSHT
Y247 HTSDVTDYSYPATPN
Y285 NQGAEHEYRPSSASA
Y336 LPAQIIEYYNPSGPP
K465 EQREQEAKREPVGND
Y485 SRRIAVEYSDSDDDS
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