Home

WASF3 (human)

Overview WASF3 Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family. Note: This description may include information from UniProtKB. Protein type: Actin binding protein; Motility/polarity/chemotaxis Cellular Component: cytoskeleton; cytoplasm Molecular Function: actin binding Biological Process: regulation of cell shape; actin filament polymerization; cytoskeleton organization and biogenesis; protein complex assembly Reference #:  Q9UPY6 (UniProtKB) Alt. Names/Synonyms: Brush-1; KIAA0900; Protein WAVE-3; SCAR3; Verprolin homology domain-containing protein 3; WAS protein family, member 3; WASF3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; WAVE3; Wiskott-Aldrich syndrome protein family member 3 Gene Symbols: WASF3 Molecular weight: 55,293 Da Basal Isoelectric point: 6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below WASF3

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		R6	__MPLVKRNIEPRHL
0	1		R39	STLAAIIRQLSSLSK
0	1		S68	NFYIRANSLQDRIDR
1	0		Y151-p	KKDGLKFyTDPSyFF
0	3		Y156-p	KFyTDPSyFFDLWkE
0	3		K162-u	SyFFDLWkEKMLQDT
0	1		K183	KRRQKEQKRIDGTTR
0	1		K193	DGTTREVKKVRKARN
0	9		Y225-p	NRLSQSVyHGASSEG
0	1		S229	QSVyHGASSEGsLsP
0	1		S230	SVyHGASSEGsLsPD
0	2		S233-p	HGASSEGsLsPDTRS
0	3		S235-p	ASSEGsLsPDTRSHA
1	0		Y248-p	HASDVTDySYPATPN
0	1		Y286-p	SQAAEHEyRPPSASA
1	0		Y337-p	LPAQIIEyYNPSGPP
0	1		K466	EQREQEAKREPVGND
1	0		Y486-p	SRRIAVEySDSDDDS

	mouse
R6-m1	__MPLVKrNIEPRHL
R39-m1	STLAAIIrQLSSLSK
S68-p	NFYIRANsLQDRIDR
Y151	KKDGLKFYTDPSYFF
Y156	KFYTDPSYFFDLWkE
K162-u	SYFFDLWkEKMLQDT
K183-a	KRRQKEQkRVDGTTR
K193-a	DGTTREVkKVRKARN
H225	NRLSQSVHHGAssEG
S229-p	QSVHHGAssEGsLsP
S230-p	SVHHGAssEGsLsPD
S233-p	HGAssEGsLsPDTRS
S235-p	AssEGsLsPDTRSHT
Y248	HTSDVTDYSYPATPN
Y286	NQGAEHEYRPSSASA
Y337	LPAQIIEYYSPSGPP
K465-u	EQREQEAkREPVGND
Y485	SRRIAVEYSDSDDDS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.