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Protein Page:
WASF3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
WASF3 Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Binds actin and the Arp2/3 complex. Expressed in ovary and brain. Belongs to the SCAR/WAVE family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: cytoskeleton; lamellipodium; cytoplasm
Molecular Function: actin binding
Biological Process: positive regulation of myelination; lamellipodium biogenesis; regulation of cell shape; actin filament polymerization; cytoskeleton organization and biogenesis; protein complex assembly; oligodendrocyte development
Reference #:  Q9UPY6 (UniProtKB)
Alt. Names/Synonyms: Brush-1; KIAA0900; Protein WAVE-3; SCAR3; Verprolin homology domain-containing protein 3; WAS protein family, member 3; WASF3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; WAVE3; Wiskott-Aldrich syndrome protein family member 3
Gene Symbols: WASF3
Molecular weight: 55,293 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WASF3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S68 NFYIRANSLQDRIDR
1 0 Y151-p KKDGLKFyTDPSyFF
0 3 Y156-p KFyTDPSyFFDLWkE
0 3 K162-u SyFFDLWkEKMLQDT
0 9 Y225-p NRLSQSVyHGASSEG
0 1 S229 QSVyHGASSEGSLsP
0 1 S230 SVyHGASSEGSLsPD
0 2 S233 HGASSEGSLsPDTRS
0 3 S235-p ASSEGSLsPDTRSHA
1 0 Y248-p HASDVTDySYPATPN
1 0 Y337-p LPAQIIEyYNPSGPP
0 1 K466 EQREQEAKREPVGND
1 0 Y486-p SRRIAVEySDSDDDS
  mouse

 
S68-p NFYIRANsLQDRIDR
Y151 KKDGLKFYTDPSYFF
Y156 KFYTDPSYFFDLWkE
K162-u SYFFDLWkEKMLQDT
H225 NRLSQSVHHGAssEG
S229-p QSVHHGAssEGsLsP
S230-p SVHHGAssEGsLsPD
S233-p HGAssEGsLsPDTRS
S235-p AssEGsLsPDTRSHT
Y248 HTSDVTDYSYPATPN
Y337 LPAQIIEYYSPSGPP
K465-u EQREQEAkREPVGND
Y485 SRRIAVEYSDSDDDS
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