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Protein Page:
VPS13A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VPS13A May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. Defects in VPS13A are the cause of chorea-acanthocytosis (CHAC); also known as Levine-Critchley syndrome. CHAC is an autosomal recessive neurodegenerative disorder characterized by the gradual onset of hyperkinetic movements and abnormal erythrocyte morphology. Basal ganglia atrophy in the brain is a pathological feature of the disease. Other clinical symptoms include psychiatric features, epilepsy, peripheral neuropathy, myopathy and oral self-mutilation. Belongs to the VPS13 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: intracellular
Molecular Function: protein binding
Biological Process: cell death; nervous system development; protein localization; protein transport; Golgi to endosome transport; locomotory behavior; social behavior
Reference #:  Q96RL7 (UniProtKB)
Alt. Names/Synonyms: CHAC; Chorea-acanthocytosis protein; Chorein; FLJ42030; KIAA0986; vacuolar protein sorting 13 homolog A (S. cerevisiae); vacuolar protein sorting 13A; Vacuolar protein sorting-associated protein 13A; VP13A; VPS13A
Gene Symbols: VPS13A
Molecular weight: 360,276 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
Select Structure to View Below

VPS13A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y365-p HRQKVKQyKELykkK
0 1 Y369-p VKQyKELykkKLTSK
0 1 K370-ac KQyKELykkKLTSKK
0 1 K371-ac QyKELykkKLTSKKP
0 1 T374 ELykkKLTSKKPPGE
0 1 S375 LykkKLTSKKPPGEL
0 1 P379 KLTSKKPPGELLVSL
0 2 Y467-p PEEKALLyEAIGYSE
0 1 Y706-p KEIMDRAyDsFDIQL
0 1 S708-p IMDRAyDsFDIQLTS
0 5 S835 LLELPSVSEDDSEEE
0 11 S839 PSVSEDDSEEEFFDA
0 4 S849 EFFDAPCSPLEEPLQ
0 1 T1029-p APVSTTEtEDKGDVI
0 1 K1037-ac EDKGDVIkKLALKLS
0 1 S1409-p DLTMVLYsPGPKQAs
0 1 S1416-p sPGPKQAsFTDVRDP
0 1 K1614 ACPFLPVKRKGKITT
0 1 S1654-p KSLTLKVsPVIINTM
0 1 T1932-p NDHFNAMtSLSSKLF
0 1 S1936 NAMtSLSSKLFFILL
0 2 Y1964-p TKVGRRLytVRHREs
0 1 T1965-p KVGRRLytVRHREsG
0 1 S1971-p ytVRHREsGVERsIV
0 1 S1976-p REsGVERsIVCQIDt
0 1 T1983-p sIVCQIDtVEGsKKV
0 2 S1987-p QIDtVEGsKKVTIRS
0 4 K2228-ub TGRMLQYkADGIHRK
0 1 Y2240 HRKHPPNYKKPVLFS
0 1 K2241 RKHPPNYKKPVLFSF
0 1 T2297 MDYQVGVTIDLSSFN
0 1 S2301 VGVTIDLSSFNITRI
0 1 S2302 GVTIDLSSFNITRIV
0 1 T2306 DLSSFNITRIVtFTP
0 2 T2310-p FNITRIVtFTPFYMI
0 1 Y2315 IVtFTPFYMIKNKSK
0 1 K2322 YMIKNKSKYHISVAE
0 1 S2552-p AYIGITSsDVVWETK
0 1 K2572-ac RWKPMSVkHTEkLER
0 1 K2576-ac MSVkHTEkLEREFKE
0 2 S2588 FKEYTESSPSEDKVI
0 1 Y2626-p VIALRRNyLPALKVE
0 2 K2923-ub GLAGAASkITGAMAK
0 1 S2973 GLVSGFVSGITGIVT
0 1 K2981-ub GITGIVTkPIkGAQk
0 6 K2984-ub GIVTkPIkGAQkGGA
0 4 K2988-ub kPIkGAQkGGAAGFF
0 1 K3000-ub GFFKGVGkGLVGAVA
0 1 T3101-p VLFVTKGtFGQLTCE
0 1 T3117-p QYSFDEFtKEPFIVH
0 1 K3152 FGKIINFKTPEDARW
0 5 S3171-p LQEAREPsPsL____
0 1 S3173-p EAREPsPsL______
  VPS13A iso2  
Y365 HRQKVKQYKELYkkK
Y369 VKQYKELYkkKLTSK
K370-ac KQYKELYkkKLTSKK
K371-ac QYKELYkkKLTSKKP
T374 ELYkkKLTSKKPPGE
S375 LYkkKLTSKKPPGEL
P379 KLTSKKPPGELLVSL
Y467 PEEKALLYEAIGYSE
Y706 KEIMDRAYDSFDIQL
S708 IMDRAYDSFDIQLTS
S835 LLELPSVSEDDSEEE
S839 PSVSEDDSEEEFFDA
S849 EFFDAPCSPLEEPLQ
T1029 APVSTTETEDKGDVI
K1037 EDKGDVIKKLALKLS
S1409 DLTMVLYSPGPKQAS
S1416 SPGPKQASFTDVRDP
K1614 ACPFLPVKRKGKITT
S1654 KSLTLKVSPVIINTM
T1932 NDHFNAMTSLSSKLF
S1936 NAMTSLSSKLFFILL
Y1964 TKVGRRLYTVRHRES
T1965 KVGRRLYTVRHRESG
S1971 YTVRHRESGVERSIV
S1976 RESGVERSIVCQIDT
T1983 SIVCQIDTVEGSKKV
S1987 QIDTVEGSKKVTIRS
K2228 TGRMLQYKADGIHRK
Y2240 HRKHPPNYKKPVLFS
K2241 RKHPPNYKKPVLFSF
T2297 MDYQVGVTIDLSSFN
S2301 VGVTIDLSSFNITRI
S2302 GVTIDLSSFNITRIV
T2306 DLSSFNITRIVTFTP
T2310 FNITRIVTFTPFYMI
Y2315 IVTFTPFYMIKNKSK
K2322 YMIKNKSKYHISVAE
S2552 AYIGITSSDVVWETK
K2572-ac RWKPMSVkHTEkLER
K2576-ac MSVkHTEkLEREFKE
S2588 FKEYTESSPSEDKVI
Y2626 VIALRRNYLPALKVE
K2923 GLAGAASKITGAMAK
S2973 GLVSGFVSGITGIVT
K2981 GITGIVTKPIKGAQK
K2984 GIVTKPIKGAQKGGA
K2988 KPIKGAQKGGAAGFF
K3000 GFFKGVGKGLVGAVA
- gap
- gap
- gap
- gap
- gap
  VPS13A iso3  
Y365 HRQKVKQYKELYKKK
Y369 VKQYKELYKKKLTSK
K370 KQYKELYKKKLTSKK
K371 QYKELYKKKLTSKKP
T374 ELYKKKLTSKKPPGE
S375 LYKKKLTSKKPPGEL
P379 KLTSKKPPGELLVSL
Y467 PEEKALLYEAIGYSE
Y706 KEIMDRAYDSFDIQL
S708 IMDRAYDSFDIQLTS
S835 LLELPSVSEDDSEEE
S839 PSVSEDDSEEEFFDA
S849 EFFDAPCSPLEEPLQ
T1029 APVSTTETEDKGDVI
K1037 EDKGDVIKKLGLDSE
S1370 DLTMVLYSPGPKQAS
S1377 SPGPKQASFTDVRDP
K1575 ACPFLPVKRKGKITT
S1615 KSLTLKVSPVIINTM
T1893 NDHFNAMTSLSSKLF
S1897 NAMTSLSSKLFFILL
Y1925 TKVGRRLYTVRHRES
T1926 KVGRRLYTVRHRESG
S1932 YTVRHRESGVERSIV
S1937 RESGVERSIVCQIDT
T1944 SIVCQIDTVEGSKKV
S1948 QIDTVEGSKKVTIRS
K2189 TGRMLQYKADGIHRK
Y2201 HRKHPPNYKKPVLFS
K2202 RKHPPNYKKPVLFSF
T2258 MDYQVGVTIDLSSFN
S2262 VGVTIDLSSFNITRI
S2263 GVTIDLSSFNITRIV
T2267 DLSSFNITRIVTFTP
T2271 FNITRIVTFTPFYMI
Y2276 IVTFTPFYMIKNKSK
K2283 YMIKNKSKYHISVAE
S2513 AYIGITSSDVVWETK
K2533 RWKPMSVKHTEKLER
K2537 MSVKHTEKLEREFKE
S2549 FKEYTESSPSEDKVI
Y2587 VIALRRNYLPALKVE
K2884 GLAGAASKITGAMAK
S2934 GLVSGFVSGITGIVT
K2942 GITGIVTKPIKGAQK
K2945 GIVTKPIKGAQKGGA
K2949 KPIKGAQKGGAAGFF
K2961 GFFKGVGKGLVGAVA
T3062 VLFVTKGTFGQLTCE
T3078 QYSFDEFTKEPFIVH
K3113 FGKIINFKTPEDARW
S3132 LQEAREPSPSL____
S3134 EAREPSPSL______
  mouse

 
Y365 HRYKMKRYREFYKKK
Y369 MKRYREFYKKKLtsK
K370 KRYREFYKKKLtsKK
K371 RYREFYKKKLtsKKP
T374-p EFYKKKLtsKKPsPE
S375-p FYKKKLtsKKPsPEI
S379-p KLtsKKPsPEILMSL
Y466 PEEKSLLYEAIGYSE
Y704 EDIMHRAYDSFDIQL
S706 IMHRAYDSFDIQLTS
T831-p PLLEQPVtEDDsEEE
S835-p QPVtEDDsEEEFFDA
S845-p EFFDAPCsPLEECPQ
P1025 ASVSAAEPEDKGDII
K1033 EDKGDIIKKLALKLP
S1403 YLTMALYSPGPDEAS
S1410 SPGPDEASFTDVRDP
K1607 ACPFLPVKRKGKVTT
S1647 KSLTLKVSPVIINTI
T1925 NDHFNAMTSLSsKLF
S1929-p NAMTSLSsKLFFILL
Y1957 TKVGRRLYTVRHRES
T1958 KVGRRLYTVRHRESG
S1964 YTVRHRESGVERSII
S1969 RESGVERSIICQIDT
T1976 SIICQIDTVEGSKKV
S1980 QIDTVEGSKKVTIRS
K2221-ub TNRMLQYkADGIHRK
Y2233-p HRKHPPNytKPVLFS
T2234-p RKHPPNytKPVLFSF
T2290 MEYQVGVTINLSSFN
S2294 VGVTINLSSFNITRI
S2295 GVTINLSSFNITRIV
T2299 NLSSFNITRIVTFIP
T2303 FNITRIVTFIPFYMI
Y2308 IVTFIPFYMIKNKSk
K2315-ac YMIKNKSkYHISVAE
S2545 AYIGITSSDVVWEAK
K2565 RWKPMSVKHTEKLEK
K2569 MSVKHTEKLEKEFRE
S2581-p FREYTEAsPLEDKVV
Y2618 VIPVRRNYLPALKVE
K2915-ub GLAGAASkITSAMAK
S2965-p GLVSGFVsGITGIVT
K2973 GITGIVTKPIKGAQk
K2976 GIVTKPIKGAQkEGA
K2980-ub KPIKGAQkEGAAGFF
K2992 GFFKGVGKGLVGAVT
T3093 VLFVTKGTFGQLTCE
T3109 QYTFDEFTKEPFIVH
K3144-ub FGKIVNFkTPEDARW
S3163 LEEAREPSPRL____
R3165 EAREPSPRL______
  rat

 
Y365 HRYKMKQYREFYKKK
Y369 MKQYREFYKKKLTNK
K370 KQYREFYKKKLTNKK
K371 QYREFYKKKLTNKKP
T374 EFYKKKLTNKKPSPE
N375 FYKKKLTNKKPSPEI
S379 KLTNKKPSPEILMSL
Y466 PEEKALLYEAIGYSE
Y704 EDIMHRAYDSFDIQL
S706 IMHRAYDSFDIQLSS
T831 PLLEQSATEDDSEEE
S835 QSATEDDSEEEFFDA
S845 EFFDAPCSPLEEYPQ
P1025 ASVSAAEPEDKGDII
K1033 EDKGDIIKKLALKLP
S1403 HLIMTLYSPGPDQAS
S1410 SPGPDQASFTDVRDP
K1607-ub ACPFLPVkRKGRVTT
S1647 KSLTLKVSPVIINTI
T1925 NDHFNAMTSLSSKLF
S1929 NAMTSLSSKLFFILL
Y1957 TKVGRRLYTVRHRES
T1958 KVGRRLYTVRHRESG
S1964 YTVRHRESGVERSII
S1969 RESGVERSIICQIDT
T1976 SIICQIDTVEGSKKV
S1980 QIDTVEGSKKVTIRS
K2221 TNRMLQYKADGIHRK
Y2233 HRKHPPNYKKPVLFS
K2234 RKHPPNYKKPVLFSF
T2290-p MEYQVGVtIDLssFN
S2294-p VGVtIDLssFNItRI
S2295-p GVtIDLssFNItRIV
T2299-p DLssFNItRIVtFIP
T2303-p FNItRIVtFIPFyMI
Y2308-p IVtFIPFyMIKNKSR
R2315 yMIKNKSRYHISVTE
S2545 AYIGITSSDVVWETK
K2565 RWKPMSVKHTEKLEK
K2569 MSVKHTEKLEKEFRE
S2581 FREYTESSPLEDKVV
Y2619 VIAVRRNYLPALKVE
K2916 GLAGAASKITSAMAK
S2966 GLVSGFVSGITGIVT
K2974 GITGIVTKPIKGAQK
K2977 GIVTKPIKGAQKEGA
K2981 KPIKGAQKEGAAGFF
K2993 GFFKGVGKGLVGAVA
T3094 VLFVTKGTFGQLTCE
T3110 QYTFDEFTKEPFIVH
K3145 FGKIINFKTPEDARW
S3164 LEEAREPSPRL____
R3166 EAREPSPRL______
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