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Protein Page:
VPS13A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VPS13A May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane. Defects in VPS13A are the cause of chorea-acanthocytosis (CHAC); also known as Levine-Critchley syndrome. CHAC is an autosomal recessive neurodegenerative disorder characterized by the gradual onset of hyperkinetic movements and abnormal erythrocyte morphology. Basal ganglia atrophy in the brain is a pathological feature of the disease. Other clinical symptoms include psychiatric features, epilepsy, peripheral neuropathy, myopathy and oral self-mutilation. Belongs to the VPS13 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: intracellular
Molecular Function: protein binding
Biological Process: cell death; nervous system development; protein localization; protein transport; Golgi to endosome transport; locomotory behavior; social behavior
Reference #:  Q96RL7 (UniProtKB)
Alt. Names/Synonyms: CHAC; Chorea-acanthocytosis protein; Chorein; FLJ42030; KIAA0986; vacuolar protein sorting 13 homolog A (S. cerevisiae); vacuolar protein sorting 13A; Vacuolar protein sorting-associated protein 13A; VP13A; VPS13A
Gene Symbols: VPS13A
Molecular weight: 360,276 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
Select Structure to View Below

VPS13A

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 5 S835 LLELPSVSEDDSEEE
0 10 S839 PSVSEDDSEEEFFDA
0 4 S849 EFFDAPCSPLEEPLQ
0 1 S1416-p SPGPKQAsFTDVRDP
0 1 S1936 NAMTSLSSKLFFILL
0 2 Y1964-p TKVGRRLyTVRHRES
0 4 K2228-u TGRMLQYkADGIHRK
0 1 Y2240 HRKHPPNYKKPVLFS
0 1 K2241 RKHPPNYKKPVLFSF
0 1 T2297 MDYQVGVTIDLSSFN
0 1 S2301 VGVTIDLSSFNITRI
0 1 S2302 GVTIDLSSFNITRIV
0 1 T2306 DLSSFNITRIVtFTP
0 2 T2310-p FNITRIVtFTPFYMI
0 1 Y2315 IVtFTPFYMIKNKSK
0 2 S2588 FKEYTESSPSEDKVI
0 1 Y2626-p VIALRRNyLPALKVE
0 2 K2923-u GLAGAASkITGAMAK
0 6 K2984-u GIVTKPIkGAQkGGA
0 4 K2988-u KPIkGAQkGGAAGFF
0 1 K3000-u GFFKGVGkGLVGAVA
0 1 K3152 FGKIINFKTPEDARW
0 5 S3171-p LQEAREPsPSL____
  VPS13A iso2  
S835 LLELPSVSEDDSEEE
S839 PSVSEDDSEEEFFDA
S849 EFFDAPCSPLEEPLQ
S1416 SPGPKQASFTDVRDP
S1936 NAMTSLSSKLFFILL
Y1964 TKVGRRLYTVRHRES
K2228 TGRMLQYKADGIHRK
Y2240 HRKHPPNYKKPVLFS
K2241 RKHPPNYKKPVLFSF
T2297 MDYQVGVTIDLSSFN
S2301 VGVTIDLSSFNITRI
S2302 GVTIDLSSFNITRIV
T2306 DLSSFNITRIVTFTP
T2310 FNITRIVTFTPFYMI
Y2315 IVTFTPFYMIKNKSK
S2588 FKEYTESSPSEDKVI
Y2626 VIALRRNYLPALKVE
K2923 GLAGAASKITGAMAK
K2984 GIVTKPIKGAQKGGA
K2988 KPIKGAQKGGAAGFF
K3000 GFFKGVGKGLVGAVA
- under review  
- gap
  VPS13A iso3  
S835 LLELPSVSEDDSEEE
S839 PSVSEDDSEEEFFDA
S849 EFFDAPCSPLEEPLQ
S1377 SPGPKQASFTDVRDP
S1897 NAMTSLSSKLFFILL
Y1925 TKVGRRLYTVRHRES
K2189 TGRMLQYKADGIHRK
Y2201 HRKHPPNYKKPVLFS
K2202 RKHPPNYKKPVLFSF
T2258 MDYQVGVTIDLSSFN
S2262 VGVTIDLSSFNITRI
S2263 GVTIDLSSFNITRIV
T2267 DLSSFNITRIVTFTP
T2271 FNITRIVTFTPFYMI
Y2276 IVTFTPFYMIKNKSK
S2549 FKEYTESSPSEDKVI
Y2587 VIALRRNYLPALKVE
K2884 GLAGAASKITGAMAK
K2945 GIVTKPIKGAQKGGA
K2949 KPIKGAQKGGAAGFF
K2961 GFFKGVGKGLVGAVA
K3113 FGKIINFKTPEDARW
S3132 LQEAREPSPSL____
  mouse

 
T831-p PLLEQPVtEDDsEEE
S835-p QPVtEDDsEEEFFDA
S845-p EFFDAPCsPLEECPQ
S1410 SPGPDEASFTDVRDP
S1929-p NAMTSLSsKLFFILL
Y1957 TKVGRRLYTVRHRES
K2221-u TNRMLQYkADGIHRK
Y2233-p HRKHPPNytKPVLFS
T2234-p RKHPPNytKPVLFSF
T2290 MEYQVGVTINLSSFN
S2294 VGVTINLSSFNITRI
S2295 GVTINLSSFNITRIV
T2299 NLSSFNITRIVTFIP
T2303 FNITRIVTFIPFYMI
Y2308 IVTFIPFYMIKNKSK
S2581-p FREYTEAsPLEDKVV
Y2618 VIPVRRNYLPALKVE
K2915-u GLAGAASkITSAMAK
K2976 GIVTKPIKGAQkEGA
K2980-u KPIKGAQkEGAAGFF
K2992 GFFKGVGKGLVGAVT
K3144-u FGKIVNFkTPEDARW
S3163 LEEAREPSPRL____
  rat

 
T831 PLLEQSATEDDSEEE
S835 QSATEDDSEEEFFDA
S845 EFFDAPCSPLEEYPQ
S1410 SPGPDQASFTDVRDP
S1929 NAMTSLSSKLFFILL
Y1957 TKVGRRLYTVRHRES
K2221 TNRMLQYKADGIHRK
Y2233 HRKHPPNYKKPVLFS
K2234 RKHPPNYKKPVLFSF
T2290-p MEYQVGVtIDLssFN
S2294-p VGVtIDLssFNItRI
S2295-p GVtIDLssFNItRIV
T2299-p DLssFNItRIVtFIP
T2303-p FNItRIVtFIPFyMI
Y2308-p IVtFIPFyMIKNKSR
S2581 FREYTESSPLEDKVV
Y2619 VIAVRRNYLPALKVE
K2916 GLAGAASKITSAMAK
K2977 GIVTKPIKGAQKEGA
K2981 KPIKGAQKEGAAGFF
K2993 GFFKGVGKGLVGAVA
K3145 FGKIINFKTPEDARW
S3164 LEEAREPSPRL____
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