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Protein Page:
SCAI (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SCAI Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Belongs to the SCAI family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription, coactivator/corepressor
Cellular Component: cytoplasm; integral to membrane; nucleus
Molecular Function: protein binding; transcription corepressor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of Rho protein signal transduction; negative regulation of cell migration
Reference #:  Q8N9R8 (UniProtKB)
Alt. Names/Synonyms: C9orf126; FLJ11758; FLJ36664; MGC120525; MGC120526; MGC120528; NET40; Protein SCAI; SCAI; suppressor of cancer cell invasion; Suppressor of cancer cell invasion protein
Gene Symbols: SCAI
Molecular weight: 70,399 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SCAI

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T22-p LAPRLTGtVEKPPRK
0 1 - gap
0 1 R33 PPRKRRSRTEFALKE
0 1 K39 SRTEFALKEIMSSGG
0 2 Y64 KTVTDFCYLLDKSKQ
0 1 K68 DFCYLLDKSKQLFNG
0 1 K103 DVYTKLWKFQQQHRQ
0 1 Y181-p LVVKKLRyYARFIVV
0 1 T445 SVAYKNFTNLFGQPL
0 1 T602 RNVFFENTIDDY___
  SCAI iso2  
T22 LAPRLTGTVEKPPRK
S33-p PPRKRRSsIRGSGDS
K56-m3 RYQHFTEkTEFALkE
K62-m3 EkTEFALkEIMSSGG
Y87 KTVTDFCYLLDKSKQ
K91 DFCYLLDKSKQLFNG
K126 DVYTKLWKFQQQHRQ
Y204 LVVKKLRYYARFIVV
T468 SVAYKNFTNLFGQPL
T625 RNVFFENTIDDY___
  mouse

 
T22 LAPRLSGTVEKPPRK
- gap
R33 PPRKRKSRTEFTLKE
K39 SRTEFTLKETMSSGG
Y64-p KTVTDFCyLLDkSKQ
K68-ub DFCyLLDkSKQLFNG
K103-ub DVYTKLWkFQQQHRQ
Y181 LVVKKLRYYARFIVV
T445-p SVAYKNFtNLFGQPL
S602-p RNIFFENsMDDY___
  rat

 
T22 LAPRLSGTVEKPPRK
- gap
R33 PPRKRKSRTEFTLKE
K39 SRTEFTLKETMSSGG
Y64 KTVTDFCYLLDKSKQ
K68 DFCYLLDKSKQLFNG
K103 DVYTKLWKFQQQHRQ
Y181 LVVKKLRYYARFIVV
T445 SVAYKNFTNLFGQPL
S602 RNIFFENSMDDY___
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