NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: centrosome; microtubule; lateral loop; paranode region of axon; perikaryon; nuclear heterochromatin; chromosome; cytosol; centriole; chromatin silencing complex; growth cone; perinuclear region of cytoplasm; cytoplasm; plasma membrane; spindle; midbody; nucleus; myelin sheath
Biological Process: chromatin silencing at rDNA; cell death; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of autophagy; meiosis; phosphoinositide 3-kinase cascade; regulation of myelination; regulation of cell cycle; chromatin silencing; positive regulation of attachment of spindle microtubules to kinetochore; response to redox state; negative regulation of transcription from RNA polymerase II promoter; gene silencing; chromatin silencing at telomere; negative regulation of cell proliferation; substantia nigra development; protein amino acid deacetylation; cellular lipid catabolic process; protein kinase B signaling cascade; positive regulation of DNA binding; mitosis; transcription, DNA-dependent; positive regulation of meiosis; regulation of phosphorylation; regulation of exit from mitosis; hepatocyte growth factor receptor signaling pathway; histone deacetylation; negative regulation of striated muscle development; negative regulation of fat cell differentiation; myelination in the peripheral nervous system; protein amino acid ADP-ribosylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cell division; innate immune response; autophagy; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-2; silencing information regulator 2-like; silent information regulator 2; SIR2; SIR2-like protein 2; sir2-related protein type 2; SIR2L; SIR2L2; SIRT2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin type 2
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.