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Protein Page:
SIRT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SIRT2 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.5.1.-; Deacetylase
Cellular Component: microtubule; centrosome; lateral loop; paranode region of axon; perikaryon; chromosome; nuclear heterochromatin; cytosol; centriole; chromatin silencing complex; growth cone; perinuclear region of cytoplasm; cytoplasm; plasma membrane; spindle; midbody; nucleus; myelin sheath
Molecular Function: ubiquitin binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; transcription factor binding; histone acetyltransferase binding; protein binding; tubulin deacetylase activity; NAD-dependent histone deacetylase activity; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; NAD+ ADP-ribosyltransferase activity
Biological Process: cell death; chromatin silencing at rDNA; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of autophagy; meiosis; phosphoinositide 3-kinase cascade; regulation of myelination; regulation of cell cycle; chromatin silencing; positive regulation of attachment of spindle microtubules to kinetochore; response to redox state; negative regulation of transcription from RNA polymerase II promoter; gene silencing; chromatin silencing at telomere; negative regulation of cell proliferation; substantia nigra development; protein amino acid deacetylation; cellular lipid catabolic process; protein kinase B signaling cascade; positive regulation of DNA binding; mitosis; regulation of phosphorylation; transcription, DNA-dependent; positive regulation of meiosis; regulation of exit from mitosis; histone deacetylation; hepatocyte growth factor receptor signaling pathway; negative regulation of striated muscle development; negative regulation of fat cell differentiation; myelination in the peripheral nervous system; protein amino acid ADP-ribosylation; positive regulation of cell division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; autophagy; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process
Reference #:  Q8IXJ6 (UniProtKB)
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-2; silencing information regulator 2-like; silent information regulator 2; SIR2; SIR2-like protein 2; sir2-related protein type 2; SIR2L; SIR2L2; SIRT2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin type 2
Gene Symbols: SIRT2
Molecular weight: 43,182 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SIRT2

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
cell adhesion, altered: S368‑p
cell growth, altered: S368‑p
cell motility, altered: S368‑p
enzymatic activity, induced: S372‑p
enzymatic activity, inhibited: S368‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 18 S23-p KVQEAQDsDsDsEGG
0 15 S25-p QEAQDsDsDsEGGAA
0 8 S27-p AQDsDsDsEGGAAGG
0 1 S53 SQTLSLGSQkERLLD
0 5 K55-ub TLSLGSQkERLLDEL
0 1 R75 ARYMQSERCRRVICL
0 1 R77 YMQSERCRRVICLVG
1 0 T101-p PDFRSPStGLyDNLE
1 3 Y104-p RSPStGLyDNLEKYH
0 1 K126 FEISYFKKHPEPFFA
0 1 K126 FEISYFKKHPEPFFA
0 1 K144 ELYPGQFKPTICHYF
0 1 H202 CVSASCRHEYPLSWM
0 1 K210 EYPLSWMKEKIFSEV
0 1 S271-p LQVQPFAsLIsKAPL
0 2 S274-p QPFAsLIsKAPLSTP
0 1 K287 TPRLLINKEKAGQSD
0 1 K312 GGMDFDSKKAYrDVA
0 1 R316-m2 FDSKKAYrDVAWLGE
0 6 K338-ac LAELLGWkKELEDLV
0 1 K338 LAELLGWKKELEDLV
0 1 K339 AELLGWkKELEDLVR
0 2 S356-p HASIDAQsGAGVPNP
0 1 A358 SIDAQsGAGVPNPsT
0 3 S364-p GAGVPNPsTsAsPKK
0 2 S366-p GVPNPsTsAsPKKsP
4 13 S368-p PNPsTsAsPKKsPPP
0 1 K371 sTsAsPKKsPPPAKD
1 11 S372-p TsAsPKKsPPPAKDE
  mouse

► Hide Isoforms
 
S23-p KVQEAQDsDsDtEGG
S25-p QEAQDsDsDtEGGAT
T27-p AQDsDsDtEGGATGG
S53-p TQTLGLGsQkERLLD
K55-ub TLGLGsQkERLLDEL
R75-m2 TRYMQSErCrKVICL
R77-m2 YMQSErCrKVICLVG
T101 PDFRSPSTGLYANLE
Y104 RSPSTGLYANLEKYH
K126-ac FEISYFKkHPEPFFA
K126-ub FEISYFKkHPEPFFA
K144-ub ELYPGQFkPTICHYF
K202-ub CVNTSCRkEYTMGWM
K210-ub EYTMGWMkEKIFSEA
S271 LQVQPFASLISKAPL
S274 QPFASLISKAPLATP
K287-ub TPRLLINkEKTGQTD
K312-ub GGMDFDSkKAYRDVA
R316 FDSkKAYRDVAWLGD
K338-ac LADLLGWkkELEDLV
K338-ub LADLLGWkkELEDLV
K339-ub ADLLGWkkELEDLVR
S356-p HANIDAQsGsQAPNP
S358-p NIDAQsGsQAPNPsT
S364-p GsQAPNPsTTIsPGk
T366 QAPNPsTTIsPGksP
S368-p PNPsTTIsPGksPPP
K371-ub sTTIsPGksPPPAKE
S372-p TTIsPGksPPPAKEA
  SIRT2 iso2  
- gap
- gap
- gap
S17 TQTLGLGSQKERLLD
K19 TLGLGSQKERLLDEL
R39 TRYMQSERCRKVICL
R41 YMQSERCRKVICLVG
T65 PDFRSPSTGLYANLE
Y68 RSPSTGLYANLEKYH
K90 FEISYFKKHPEPFFA
K90 FEISYFKKHPEPFFA
K108 ELYPGQFKPTICHYF
K166 CVNTSCRKEYTMGWM
K174 EYTMGWMKEKIFSEA
S235 LQVQPFASLISKAPL
S238 QPFASLISKAPLATP
K251 TPRLLINKEKTGQTD
K276 GGMDFDSKKAYRDVA
R280 FDSKKAYRDVAWLGD
K302 LADLLGWKKELEDLV
K302 LADLLGWKKELEDLV
K303 ADLLGWKKELEDLVR
S320 HANIDAQSGSQAPNP
S322 NIDAQSGSQAPNPST
S328 GSQAPNPSTTIsPGK
T330 QAPNPSTTIsPGKSP
S332-p PNPSTTIsPGKSPPP
K335 STTIsPGKSPPPAKE
S336 TTIsPGKSPPPAKEA
  rat

► Hide Isoforms
 
- gap
- gap
- gap
S16 TQTLGLGSQkERLLD
K18-ub TLGLGSQkERLLDEL
R38 TRYMQSERCRRVICL
R40 YMQSERCRRVICLVG
T64 PDFRSPSTGLYANLE
Y67 RSPSTGLYANLEKYH
K89 FEISYFKKHPEPFFA
K89 FEISYFKKHPEPFFA
K107 ELYPGQFKPTICHYF
K165 CVNTSCGKEYTMSWM
K173 EYTMSWMKEKIFSEA
S234 LQVQPFASLISKAPL
S237 QPFASLISKAPLATP
K250 TPRLLINKEKTGQTD
K275 GGMDFDSKKAYRDVA
R279 FDSKKAYRDVAWLGD
K301 LADLLGWKELEDLVR
K301 LADLLGWKELEDLVR
- gap
S318 HANIDAQSGSQASNP
S320 NIDAQSGSQASNPSA
S326 GSQASNPSATVSPRK
T328 QASNPSATVSPRKSP
S330 SNPSATVSPRKSPPP
K333 SATVSPRKSPPPAKE
S334 ATVSPRKSPPPAKEA
  SIRT2 iso2  
S23 KVQEAQDSDSDTEGG
S25 QEAQDSDSDTEGGAT
T27 AQDSDSDTEGGATGG
S53 TQTLGLGSQKERLLD
K55 TLGLGSQKERLLDEL
R75 TRYMQSERCRRVICL
R77 YMQSERCRRVICLVG
T101 PDFRSPSTGLYANLE
Y104 RSPSTGLYANLEKYH
K126 FEISYFKKHPEPFFA
K126 FEISYFKKHPEPFFA
K144 ELYPGQFKPTICHYF
K202 CVNTSCGKEYTMSWM
K210 EYTMSWMKEKIFSEA
S343 LQVQPFASLISKAPL
S346 QPFASLISKAPLATP
K359 TPRLLINKEKTGQTD
K384 GGMDFDSKKAYRDVA
R388 FDSKKAYRDVAWLGD
K410 LADLLGWKKELEDLV
K410 LADLLGWKKELEDLV
K411 ADLLGWKKELEDLVR
S428 HANIDAQSGSQASNP
S430 NIDAQSGSQASNPSA
S436 GSQASNPSATVSPRK
T438 QASNPSATVSPRKSP
S440 SNPSATVSPRKSPPP
K443 SATVSPRKSPPPAKE
S444 ATVSPRKSPPPAKEA
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