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Protein Page:
CDAN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CDAN1 Might be involved in nuclear membrane integrity. Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1). An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoplasm; integral to membrane; plasma membrane; nucleus
Molecular Function: protein binding
Biological Process: negative regulation of DNA replication; chromatin assembly
Reference #:  Q8IWY9 (UniProtKB)
Alt. Names/Synonyms: CDA1; CDAI; CDAN1; codanin 1; Codanin-1; congenital dyserythropoietic anemia, type I; discs lost homolog; DLT; PRO1295
Gene Symbols: CDAN1
Molecular weight: 134,120 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below

CDAN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 18 T71-p VLPQGPPtPAKtPGA
0 4 T75-p GPPtPAKtPGASAAL
0 3 S144-p EEGVSGEsLPGAGGR
0 1 S158-p RRLRGSGsPSRPSLT
0 2 S265-p RSKQLQQsPTPTCPt
0 2 T272-p sPTPTCPtPELGsPL
0 3 S277-p CPtPELGsPLPSRTG
0 1 S285-p PLPSRTGsLTDEPAD
0 2 K940-a GREFCQRkSPGAVRA
  CDAN1 iso1  
T71 VLPQGPPTPAKTPGA
T75 GPPTPAKTPGASAAL
S144 EEGVSGESLPGAGGR
S158 RRLRGSGSPSRPSLT
S264 SSKQLQQSPTPTCPT
T271 SPTPTCPTPELGSPL
S276 CPTPELGSPLPSRTG
S284 PLPSRTGSLTDEPAD
K939 GREFCQRKSPGAVRA
  mouse

 
T70-p VLPQGPStPAKtPVA
T74-p GPStPAKtPVASAAL
S148 EEGASGESPPWAGGR
S162 RKPKGSGSPGSPRLS
S270 RTKQLQQSPTPASPI
I277 SPTPASPIPESGSPV
S282 SPIPESGSPVPSRTG
N290 PVPSRTGNLTAEPAD
K945 GREFCQRKSPTAVRA
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