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Protein Page:
CDAN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDAN1 Might be involved in nuclear membrane integrity. Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1). An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cytoplasm; plasma membrane; integral to membrane; endomembrane system; nucleus
Molecular Function: protein binding
Biological Process: establishment and/or maintenance of chromatin architecture; protein localization; negative regulation of DNA replication; chromatin assembly
Reference #:  Q8IWY9 (UniProtKB)
Alt. Names/Synonyms: CDA1; CDAI; CDAN1; codanin 1; Codanin-1; congenital dyserythropoietic anemia, type I; discs lost homolog; DLT; PRO1295
Gene Symbols: CDAN1
Molecular weight: 134,120 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Select Structure to View Below

CDAN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 19 T71-p VLPQGPPtPAKtPGA
0 6 T75-p GPPtPAKtPGAsAAL
0 1 S79-p PAKtPGAsAALPGRP
0 1 S93-p PGGPPRGsRGARSQL
0 3 S144-p EEGVSGEsLPGAGGR
0 1 S156-p GGRRLRGsGsPSRPS
0 1 S158-p RRLRGsGsPSRPSLT
0 2 S265-p RSKQLQQsPTPtCPt
0 1 T269-p LQQsPTPtCPtPELG
0 2 T272-p sPTPtCPtPELGsPL
0 4 S277-p CPtPELGsPLPSRTG
0 1 S285-p PLPSRTGsLTDEPAD
0 1 S515-p QLLQMCQsPGGAGGt
0 1 T522-p sPGGAGGtVLGEAPD
0 1 S532-p GEAPDVLsMLGADKL
0 1 S590 FNQHLMDSLSLKIQE
0 1 S592 QHLMDSLSLKIQELN
0 1 S668-p DSILALRsQVPPVLD
0 1 S701-p PWLVEFLsFADHVVP
0 1 Y712-p HVVPLLEyyRDIFTL
0 1 Y713-p VVPLLEyyRDIFTLL
0 1 S811 ELRKLLASWVSGSSG
0 1 S814 KLLASWVSGSSGRSG
0 1 S816 LASWVSGSSGRSGGF
0 1 S820 VSGSSGRSGGFMRKI
0 2 K940-ac GREFCQRkSPGAVRA
  CDAN1 iso1  
T71 VLPQGPPTPAKTPGA
T75 GPPTPAKTPGASAAL
S79 PAKTPGASAALPGRP
S93 PGGPPRGSRGARSQL
S144 EEGVSGESLPGAGGR
S156 GGRRLRGSGSPSRPS
S158 RRLRGSGSPSRPSLT
S264 SSKQLQQSPTPTCPT
T268 LQQSPTPTCPTPELG
T271 SPTPTCPTPELGSPL
S276 CPTPELGSPLPSRTG
S284 PLPSRTGSLTDEPAD
S514 QLLQMCQSPGGAGGT
T521 SPGGAGGTVLGEAPD
S531 GEAPDVLSMLGADKL
S589 FNQHLMDSLSLKIQE
S591 QHLMDSLSLKIQELN
S667 DSILALRSQVPPVLD
S700 PWLVEFLSFADHVVP
Y711 HVVPLLEYYRDIFTL
Y712 VVPLLEYYRDIFTLL
S810 ELRKLLASWVSGSSG
S813 KLLASWVSGSSGRSG
S815 LASWVSGSSGRSGGF
S819 VSGSSGRSGGFMRKI
K939 GREFCQRKSPGAVRA
  mouse

 
T70-p VLPQGPStPAKtPVA
T74-p GPStPAKtPVASAAL
S78 PAKtPVASAALPARQ
G92 QGAPARGGRGARSQL
S148 EEGASGESPPWAGGR
S160 GGRKPKGSGSPGSPR
S162 RKPKGSGSPGSPRLS
S270 RTKQLQQSPTPASPI
A274 LQQSPTPASPIPESG
I277 SPTPASPIPESGSPV
S282 SPIPESGSPVPSRTG
N290 PVPSRTGNLTAEPAD
S520 QLLQMCQSPGGAGGS
S527 SPGGAGGSVLGEAPD
N537 GEAPDVLNMLGADKL
S595-p FNQHLMDsLsLKIRE
S597-p QHLMDsLsLKIRELN
S673 DSILALRSQVPPVLD
S706 PWLVEFLSFADHIVP
Y717 HIVPLLDYYRSVFTL
Y718 IVPLLDYYRSVFTLL
S816-p ELRKLLAsWVsGsSG
S819-p KLLAsWVsGsSGRsG
S821-p LAsWVsGsSGRsGGF
S825-p VsGsSGRsGGFVRKI
K945 GREFCQRKSPTAVRA
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