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KTN1 (human)

Overview KTN1 Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms. High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon. Belongs to the kinectin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral Cellular Component: endoplasmic reticulum membrane; membrane; integral to plasma membrane; endoplasmic reticulum; integral to membrane Molecular Function: kinesin binding Biological Process: microtubule-based movement Reference #:  Q86UP2 (UniProtKB) Alt. Names/Synonyms: CG-1 antigen; CG1; KIAA0004; Kinectin; kinectin 1 (kinesin receptor); Kinesin receptor; KNT; KTN1; MGC133337; MU-RMS-40.19 Gene Symbols: KTN1 Molecular weight: 156,275 Da Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below KTN1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K40	LYDEVLAKQKREQKL
0	6		N71	KKEIQNGNLHEsDsE
0	32		S75-p	QNGNLHEsDsEsVPR
0	11		S77-p	GNLHEsDsEsVPRDF
0	1		S79-p	LHEsDsEsVPRDFKL
0	1		L90	DFKLSDALAVEDDQV
0	1		S110-p	NVVETSSsVRERKKK
0	1		K131	VLEEQVIKESDASKI
0	11		T153-p	VPVTKQPtPPsEAAA
0	1		S156-p	TKQPtPPsEAAASKK
0	1		K217	KASSKKQKTENVFVD
0	2		Y233-p	PLIHATTyIPLMDNA
0	1		S243-p	LMDNADSsPVVDKRE
0	1		K256-u	REVIDLLkPDQVEGI
0	1		K265-a	DQVEGIQkSGTkkLK
0	1		K269-a	GIQkSGTkkLKTETD
0	1		K270-a	IQkSGTkkLKTETDK
0	2		K285-u	ENAEVKFkDFLLSLK
1	1		K309-u	LCVVDLLkEKSGVIQ
0	2		K320-a	GVIQDALkkSSkGEL
0	2		K321-a	VIQDALkkSSkGELT
0	2		K324-a	DALkkSSkGELTTLI
0	1		T359-p	KDRCKQLtQEMMtEK
0	2		T364-p	QLtQEMMtEKERSNV
0	1		N370	MtEKERSNVVITRMK
0	2		T619-p	KDKQIKQtEDsLASE
0	2		S622-p	QIKQtEDsLASERDR
0	1		T746-p	EKDEKLKtVEELLET
0	4		K761-u	GLIQVATkEEELNAI
0	1		K777-u	TENSSLTkEVQDLKA
0	1		K785	EVQDLKAKQNDQVsF
0	1		S791-p	AKQNDQVsFASLVEE
0	1		K800	ASLVEELKKVIHEKD
0	1		K811	HEKDGKIKsVEELLE
0	1		S812-p	EKDGKIKsVEELLEA
0	1		T830-p	KVANKEKtVQDLKQE
0	1		S906-p	DLQEENEsLKAHVQE
0	1		K971	QDVQDENKLFKSQIE
0	1		K1176-u	DESHKTIkQMQSSFT
0	3		Y1353-p	LTKEKEHyQVLE___

	mouse
K40-u	LYDEVLAkQKREQKL
T71-p	KKEIQNGtLREsDsE
S75-p	QNGtLREsDsEHVPR
S77-p	GtLREsDsEHVPRDF
H79	LREsDsEHVPRDFKL
S90-p	DFKLSDAsPAEDEQF
S110	NVAETSSSVRERQKK
K131-a	SLEEQVIkESDASKI
A153	VLVTKQPAPPPPLEA
P156	TKQPAPPPPLEAAAL
K219-a	KGLSKKQkSENVAVL
Y237	PLIHATTYMPLDNAN
N246	PLDNANSNLMMDKRE
K259	REIIDMIKPDHVEGI
K268	DHVEGIQKSGTKKLK
K272	GIQKSGTKKLKIETD
K273	IQKSGTKKLKIETDK
K288-u	ENAEVKFkDFLLSLK
K312	LCVVDLLKEKSGVIK
K323	GVIKEALKKSNKGEL
K324	VIKEALKKSNKGELS
K327	EALKKSNKGELSGLL
T362	KERCKRLTQEMMtEK
T367-p	RLTQEMMtEKERSsV
S373-p	MtEKERSsVVIARMK
T622	KDKQLKQTEDSLANE
S625	QLKQTEDSLANEQDH
T749	EKDEKLRTVEELLET
R764	GLIQVATREEELSAI
R780	TENSTLTREVQELKA
K788-u	EVQELKAkQSDQVSF
S794	AkQSDQVSFVSLIED
K803-u	VSLIEDLkRVIHEKD
K814-u	HEKDGQIkSVEELLE
S815	EKDGQIkSVEELLEV
T833	KVANKEKTVQALKQE
-	under review
K951-u	KEVQEENkFLKCQLS
K1152	DESQRMIKQMQSSFT
-	gap

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