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Protein Page:
KTN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KTN1 Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms. High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon. Belongs to the kinectin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: endoplasmic reticulum membrane; membrane; integral to plasma membrane; integral to membrane
Molecular Function: kinesin binding
Biological Process: microtubule-based movement
Reference #:  Q86UP2 (UniProtKB)
Alt. Names/Synonyms: CG-1 antigen; CG1; KIAA0004; Kinectin; kinectin 1 (kinesin receptor); Kinesin receptor; KNT; KTN1; MGC133337; MU-RMS-40.19
Gene Symbols: KTN1
Molecular weight: 156,275 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KTN1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 N71 KKEIQNGNLHEsDsE
0 37 S75-p QNGNLHEsDsEsVPR
0 12 S77-p GNLHEsDsEsVPRDF
0 2 S79-p LHEsDsEsVPRDFKL
0 1 L90 DFKLSDALAVEDDQV
0 1 S110-p NVVETSSsVRERKKK
0 1 T149-p KVEPVPVtKQPtPPs
0 13 T153-p VPVtKQPtPPsEAAA
0 1 S156-p tKQPtPPsEAAASKK
0 2 Y233-p PLIHATTyIPLMDNA
0 1 K256-u REVIDLLkPDQVEGI
0 1 K265-a DQVEGIQkSGTkkLK
0 1 K269-a GIQkSGTkkLKTETD
0 1 K270-a IQkSGTkkLKTETDK
0 2 K285-u ENAEVKFkDFLLSLK
1 1 K309-u LCVVDLLkEKSGVIQ
0 2 K320-a GVIQDALkkSSkGEL
0 2 K321-a VIQDALkkSSkGELT
0 2 K324-a DALkkSSkGELTTLI
0 2 T364-p QLTQEMMtEKERSNV
0 1 T537 QSLHSKLTDTLVSKQ
0 1 S556 RLMQLMESEQKRVNK
0 2 T619-p KDKQIKQtEDsLASE
0 2 S622-p QIKQtEDsLASERDR
0 4 K761-u GLIQVATkEEELNAI
0 1 K785 EVQDLKAKQNDQVsF
0 1 S791-p AKQNDQVsFASLVEE
0 1 K800 ASLVEELKKVIHEKD
0 1 S812-p EKDGKIKsVEELLEA
0 1 T830-p KVANKEKtVQDLKQE
0 1 S906-p DLQEENEsLKAHVQE
0 1 K971 QDVQDENKLFKSQIE
0 1 S1313-p VIENSDVsPETESSE
0 3 Y1353-p LTKEKEHyQVLE___
  mouse

 
T71-p KKEIQNGtLREsDsE
S75-p QNGtLREsDsEHVPR
S77-p GtLREsDsEHVPRDF
H79 LREsDsEHVPRDFKL
S90-p DFKLSDAsPAEDEQF
S110 NVAETSSSVRERQKK
T149 KVEPVLVTKQPAPPP
A153 VLVTKQPAPPPPLEA
P156 TKQPAPPPPLEAAAL
Y237 PLIHATTYMPLDNAN
K259 REIIDMIKPDHVEGI
K268 DHVEGIQKSGTKKLK
K272 GIQKSGTKKLKIETD
K273 IQKSGTKKLKIETDK
K288-u ENAEVKFkDFLLSLK
K312 LCVVDLLKEKSGVIK
K323 GVIKEALKKSNKGEL
K324 VIKEALKKSNKGELS
K327 EALKKSNKGELSGLL
T367-p RLTQEMMtEKERSSV
T540-p QSLHSKLtDTLVSKQ
S559-p RLMQLMEsEQKRASK
T622 KDKQLKQTEDSLANE
S625 QLKQTEDSLANEQDH
R764 GLIQVATREEELSAI
K788-u EVQELKAkQSDQVSF
S794 AkQSDQVSFVSLIED
K803-u VSLIEDLkRVIHEKD
S815 EKDGQIKSVEELLEV
T833 KVANKEKTVQALKQE
- gap
K951-u KEVQEENkFLKCQLS
S1290 VIENSDISPEMESPE
- gap
  rat

 
T71 KKEIQNGTLHEsDSE
S75-p QNGTLHEsDSEHVPQ
S77 GTLHEsDSEHVPQDF
H79 LHEsDSEHVPQDFKL
S90 DFKLSDASPVEDEQF
S110 SVAETSSSVRERKKK
T149 KVEPVLVTEQPAPPP
A153 VLVTEQPAPPPEAAA
P156 TEQPAPPPEAAALKK
S235 PLTHATASVPSVDNA
K258 RGVTDMIKPDQVEGI
K267 DQVEGIQKSGTKKLK
K271 GIQKSGTKKLKIDTD
K272 IQKSGTKKLKIDTDK
K287 ENAEVKFKNFLLSLK
K311 LCVVDLLKEKSGVIK
K322 GVIKEALKKSNKGEL
K323 VIKEALKKSNKGELS
K326 EALKKSNKGELSGLL
T366 QLTQEMMTEKERSSV
T539 QSLHSKLTDTLVSKQ
S558 RLMQLMESEQKRASQ
T621 KDKQLKQTEDSLASE
S624 QLKQTEDSLASEQDH
R763 GLIQVATREEELNAI
K787 EVQELKAKQMDQVPF
P793 AKQMDQVPFVSLIED
K802 VSLIEDLKKVIHEKD
S814 EKDGQIKSVEELLEV
T832 KVANKEKTVQALKQE
- gap
K946 KEVQDENKLFKSQVE
S1288 VIENNDISPEMGSPE
- gap
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