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Protein Page:
KTN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
KTN1 Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin. Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms. High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon. Belongs to the kinectin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; membrane; integral to plasma membrane; endoplasmic reticulum; integral to membrane
Molecular Function: kinesin binding
Biological Process: microtubule-based movement
Reference #:  Q86UP2 (UniProtKB)
Alt. Names/Synonyms: CG-1 antigen; CG1; KIAA0004; Kinectin; kinectin 1 (kinesin receptor); Kinesin receptor; KNT; KTN1; MGC133337; MU-RMS-40.19
Gene Symbols: KTN1
Molecular weight: 156,275 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KTN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K40 LYDEVLAKQKREQKL
0 7 N71 KKEIQNGNLHEsDsE
0 40 S75-p QNGNLHEsDsEsVPR
0 13 S77-p GNLHEsDsEsVPRDF
0 2 S79-p LHEsDsEsVPRDFKL
0 1 L90 DFKLSDALAVEDDQV
0 1 S110-p NVVETSSsVRERKKK
0 1 K131 VLEEQVIKESDASKI
0 2 T149-p KVEPVPVtKQPtPPs
0 15 T153-p VPVtKQPtPPsEAAA
0 2 S156-p tKQPtPPsEAAAsKK
0 1 S161-p PPsEAAAsKKKPGQK
0 1 K217 KASSKKQKTENVFVD
0 2 Y233-p PLIHATTyIPLMDNA
0 1 S243-p LMDNADSsPVVDKRE
0 1 K256-ub REVIDLLkPDQVEGI
0 1 K265-ac DQVEGIQkSGTkkLK
0 1 K269-ac GIQkSGTkkLKTETD
0 1 K270-ac IQkSGTkkLKTETDK
0 2 K285-ub ENAEVKFkDFLLSLK
1 1 K309-ub LCVVDLLkEKSGVIQ
0 2 K320-ac GVIQDALkkSSkGEL
0 2 K321-ac VIQDALkkSSkGELT
0 2 K324-ac DALkkSSkGELTTLI
0 1 K345-sc DKLLAAVkEDAAATK
0 1 T359-p KDRCKQLtQEMMtEK
0 2 T364-p QLtQEMMtEKERSNV
0 1 N370 MtEKERSNVVITRMK
0 1 S442-p NTTNQLEsKQSAELN
0 1 T537 QSLHSKLTDTLVSKQ
0 1 S556 RLMQLMESEQKRVNK
0 2 T619-p KDKQIKQtEDsLASE
0 2 S622-p QIKQtEDsLASERDR
0 1 T746-p EKDEKLKtVEELLET
0 4 K761-ub GLIQVATkEEELNAI
0 1 K777-ub TENSSLTkEVQDLKA
0 1 K785 EVQDLKAKQNDQVsF
0 1 S791-p AKQNDQVsFASLVEE
0 1 K800 ASLVEELKKVIHEKD
0 1 K811 HEKDGKIKsVEELLE
0 2 S812-p EKDGKIKsVEELLEA
0 1 T830-p KVANKEKtVQDLkQE
0 1 K835-ac EKtVQDLkQEIKALK
0 1 K835-sc EKtVQDLkQEIKALK
0 1 S906-p DLQEENEsLKAHVQE
0 1 K971 QDVQDENKLFKSQIE
0 1 K1176-ub DESHKTIkQMQSSFT
0 1 S1313-p VIENSDVsPETESSE
0 3 Y1353-p LTKEKEHyQVLE___
  mouse

 
K40-ub LYDEVLAkQKREQKL
T71-p KKEIQNGtLREsDsE
S75-p QNGtLREsDsEHVPR
S77-p GtLREsDsEHVPRDF
H79 LREsDsEHVPRDFKL
S90-p DFKLSDAsPAEDEQF
S110 NVAETSSSVRERQKK
K131-ac SLEEQVIkESDASKI
T149 KVEPVLVTKQPAPPP
A153 VLVTKQPAPPPPLEA
P156 TKQPAPPPPLEAAAL
L163 PPLEAAALKKKAGQK
K219-ac KGLSKKQkSENVAVL
Y237 PLIHATTYMPLDNAN
N246 PLDNANSNLMMDKRE
K259 REIIDMIKPDHVEGI
K268 DHVEGIQKSGTKKLK
K272 GIQKSGTKKLKIETD
K273 IQKSGTKKLKIETDK
K288-ub ENAEVKFkDFLLSLK
K312 LCVVDLLKEKSGVIK
K323 GVIKEALKKSNKGEL
K324 VIKEALKKSNKGELS
K327 EALKKSNKGELSGLL
K348 ERLLSAMKEDAAASK
T362 KERCKRLTQEMMtEK
T367-p RLTQEMMtEKERSsV
S373-p MtEKERSsVVIARMK
S445 NTTNQLESKQSAELN
T540-p QSLHSKLtDTLVSKQ
S559-p RLMQLMEsEQKRASK
T622 KDKQLKQTEDSLANE
S625 QLKQTEDSLANEQDH
T749 EKDEKLRTVEELLET
R764 GLIQVATREEELSAI
R780 TENSTLTREVQELKA
K788-ub EVQELKAkQSDQVSF
S794 AkQSDQVSFVSLIED
K803-ub VSLIEDLkRVIHEKD
K814-ub HEKDGQIkSVEELLE
S815 EKDGQIkSVEELLEV
T833 KVANKEKTVQALKQE
K838 EKTVQALKQEIEVLK
K838 EKTVQALKQEIEVLK
- gap
K951-ub KEVQEENkFLKCQLS
K1152 DESQRMIKQMQSSFT
S1290 VIENSDISPEMESPE
- gap
  rat

 
K40 LYDDVLAKQKREQKL
T71 KKEIQNGTLHEsDSE
S75-p QNGTLHEsDSEHVPQ
S77 GTLHEsDSEHVPQDF
H79 LHEsDSEHVPQDFKL
S90 DFKLSDASPVEDEQF
S110 SVAETSSSVRERKKK
K131 SLEEHIIKESDASKI
T149 KVEPVLVTEQPAPPP
A153 VLVTEQPAPPPEAAA
P156 TEQPAPPPEAAALKK
L161 PPPEAAALKKKAGQK
K217 KGLSKKQKTENVAVL
S235 PLTHATASVPSVDNA
S245 SVDNADSSLMTDKRG
K258 RGVTDMIKPDQVEGI
K267 DQVEGIQKSGTKKLK
K271 GIQKSGTKKLKIDTD
K272 IQKSGTKKLKIDTDK
K287 ENAEVKFKNFLLSLK
K311 LCVVDLLKEKSGVIK
K322 GVIKEALKKSNKGEL
K323 VIKEALKKSNKGELS
K326 EALKKSNKGELSGLL
K347 ERLLTATKEDAAATK
T361 KERCKQLTQEMMTEK
T366 QLTQEMMTEKERSSV
S372 MTEKERSSVVMARMK
S444 NTTNQLESKQSAELN
T539 QSLHSKLTDTLVSKQ
S558 RLMQLMESEQKRASQ
T621 KDKQLKQTEDSLASE
S624 QLKQTEDSLASEQDH
T748 EKDEKLRTVEELLET
R763 GLIQVATREEELNAI
K779 TENSSLTKEVQELKA
K787 EVQELKAKQMDQVPF
P793 AKQMDQVPFVSLIED
K802 VSLIEDLKKVIHEKD
K813 HEKDGQIKSVEELLE
S814 EKDGQIKSVEELLEV
T832 KVANKEKTVQALKQE
K837 EKTVQALKQEIEILK
K837 EKTVQALKQEIEILK
- gap
K946 KEVQDENKLFKSQVE
Q1150 EESRRTIQQMQSSFT
S1288 VIENNDISPEMGSPE
- gap
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