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Protein Page:
TrkC (human)

Overview
TrkC a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Trk family
Cellular Component: integral to plasma membrane; cytoplasm; receptor complex
Molecular Function: neurotrophin binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; activation of MAPK activity; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; activation of protein kinase B; neuron migration; activation of Ras GTPase; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus; positive regulation of cell migration
Reference #:  Q16288 (UniProtKB)
Alt. Names/Synonyms: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion partner; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin 3 receptor; NT-3 growth factor receptor; NTRK3; Trk-C; TRKC; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Symbols: NTRK3
Molecular weight: 94,428 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkC

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: Y516‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y131-p AKNPHLRyINLSSNR
0 1 T141 LSSNRLTTLSWQLFQ
0 1 S151 WQLFQTLSLRELQLE
0 1 T220-p SVSHVNLtVREGDNA
0 1 T386-p IAKNPLGtANQTING
0 1 S479 SGEEDSASPLHHINH
0 1 S493 HGITTPSSLDAGPDT
2 70 Y516-p PVIENPQyFRQGHNC
0 3 Y558-p KVFLAECyNLSPTKD
0 4 S561 LAECyNLSPTKDKML
0 48 Y705-p FGMSRDVySTDyyRL
0 2 S706 GMSRDVySTDyyRLF
0 29 Y709-p RDVySTDyyRLFNPS
0 10 Y710-p DVySTDyyRLFNPSG
0 2 Y800-p RVCPKEVyDVMLGCW
1 0 Y834 LGKATPIYLDILG__
0 3 - gap
0 9 - gap
0 1 - gap
0 1 - gap
0 1 - gap
  TrkC iso2  
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELQLE
T220 SVSHVNLTVREGDNA
T386 IAKNPLGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516 PVIENPQYFRQGHNC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y555 HLVPSTHYIYEEPEV
Y557 VPSTHYIYEEPEVQS
Y597-p KPLNHGIyVEDVNVy
Y604-p yVEDVNVyFsKGRHG
S606-p EDVNVyFsKGRHGF_
  mouse

 
Y131 AKNPHLRYINLSSNR
T141-p LSSNRLTtLSWQLFQ
S151-p WQLFQTLsLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479-p SGEEDSAsPLHHINH
S493-p HGITTPSsLDAGPDT
Y516-p PVIENPQyFRQGHNC
Y558 KVFLAECYNLsPTKD
S561-p LAECYNLsPTKDKML
Y705-p FGMSRDVysTDyyRV
S706-p GMSRDVysTDyyRVG
Y709-p RDVysTDyyRVGGHT
Y710-p DVysTDyyRVGGHTM
Y786 RVCPKEVYDVMLGCW
Y820 LGKATPIYLDILG__
- gap
- gap
- gap
- gap
- gap
  rat

► Hide Isoforms
 
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516-p PVIENPQyFRQGHNC
Y558-p KVFLAECyNLSPTKD
S561 LAECyNLSPTKDKML
Y705-p FGMSRDVySTDyyRE
S706 GMSRDVySTDyyREG
Y709-p RDVySTDyyREGPYQ
Y710-p DVySTDyyREGPYQK
Y825 RVCPKEVYDVMLGCW
Y859-p LGKATPIyLDILG__
- gap
- gap
- gap
- gap
- gap
  TrkC iso2  
Y131 AKNPHLRYINLSSNR
T141 LSSNRLTTLSWQLFQ
S151 WQLFQTLSLRELRLE
T220 SVSHVNLTVREGDNA
T386 IAKNALGTANQTING
S479 SGEEDSASPLHHINH
S493 HGITTPSSLDAGPDT
Y516-p PVIENPQyFRQGHNC
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y555-p HLVPSTHyIyEEPEV
Y557-p VPSTHyIyEEPEVQS
Y597 KPLNHGIYVEDVNVY
Y604 YVEDVNVYFSKGRHG
S606 EDVNVYFSKGRHGF_
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