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TrkC
a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; TK group; Trk family |
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Cellular Component: Golgi membrane; integral to plasma membrane
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Molecular Function: neurotrophin binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
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Biological Process: mechanoreceptor differentiation; response to ethanol; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron migration; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus
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Reference #:
Q16288 (UniProtKB)
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| Alt. Names/Synonyms: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion partner; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin 3 receptor; NT-3 growth factor receptor; NTRK3; Trk-C; TRKC; TrkC tyrosine kinase; tyrosine kinase receptor C |
| Gene Symbols: NTRK3 |
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Molecular weight: 94,428 Da
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Basal Isoelectric point: 6.12
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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