a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 18.104.22.168; Kinase, protein; TK group; Trk family
Cellular Component: Golgi membrane; integral to plasma membrane
Molecular Function: neurotrophin binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: mechanoreceptor differentiation; response to ethanol; positive regulation of axon extension involved in regeneration; protein amino acid autophosphorylation; negative regulation of astrocyte differentiation; modification by virus of host cell transcription; neuron migration; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.