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DNAJC3 (human)

Overview DNAJC3 Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Note: This description may include information from UniProtKB. Protein type: Inhibitor protein; Chaperone; Protein kinase, regulatory subunit; Kinase, protein; Endoplasmic reticulum Cellular Component: endoplasmic reticulum lumen; cytoplasm Molecular Function: protein kinase inhibitor activity; heat shock protein binding; chaperone binding; unfolded protein binding; misfolded protein binding Biological Process: unfolded protein response, activation of signaling protein activity; protein folding; proteolysis involved in cellular protein catabolic process; unfolded protein response; negative regulation of protein kinase activity; defense response to virus Reference #:  Q13217 (UniProtKB) Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ homolog subfamily C member 3; DNAJC3; DNJC3; FLJ21288; HP58; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; P58; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor Gene Symbols: DNAJC3 Molecular weight: 57,580 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DNAJC3 2Y4T - A/C/B=35-461 (human) 2Y4U - A=35-461 (human) 3IEG - A/B=35-393 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2Y4T 2Y4U  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S6-p	__MVAPGsVtsRLGS
0	1		T8-p	MVAPGsVtsRLGSVF
0	1		S9-p	VAPGsVtsRLGSVFP
0	2		K46-m2	KHLELGKkLLAAGQL
0	1		T95-p	KAALPDLtKVIQLKM
0	1		K96	AALPDLtKVIQLKMD
0	1		K133-u	DDFKKVLkSNPSENE
0	1		K150-u	EAQSQLIkSDEMQRL
0	2		K206	IKEGEPRKAISDLKA
0	1		K212	RKAISDLKAASKLKN
0	1		S215	ISDLKAASKLKNDNT
0	1		K270	KQVKKLNKLIESAEE
0	2		K290-u	RYTDATSkYESVMKT
0	1		K296	SkYESVMKTEPSIAE
0	1		K344	PDNVNALKDRAEAYL
0	1		K407-m1	GVKRNAKkQEIIKAY
0	6		K446-u	FIDIAAAkEVLSDPE

	mouse
S6	__MVAPGSVGSRLGA
G8	MVAPGSVGSRLGAVF
S9	VAPGSVGSRLGAVFP
K46	KHLELGKKLLAAGQL
T95	KAALPDLTkVIALKM
K96-u	AALPDLTkVIALKMD
K133	DDFKKVLKSNPSEQE
K150	EAESQLVKADEMQRL
K206-a	IKEGEPRkAISDLkA
K212-a	RkAISDLkAAsKLKS
S215-p	ISDLkAAsKLKSDNT
K270-u	KQVKKLNkLIESAEE
K290-u	RYTDATSkYESVMkT
K296-u	SkYESVMkTEPSVAE
K344-u	PDNVNALkDRAEAYL
K407	GVKRNAKKQEIIKAY
K446-u	FIDIAAAkEVLSDPE

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