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Protein Page:
DNAJC3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DNAJC3 Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Protein kinase, regulatory subunit; Inhibitor protein; Endoplasmic reticulum
Cellular Component: endoplasmic reticulum lumen; cytoplasm
Molecular Function: protein kinase inhibitor activity
Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; negative regulation of protein kinase activity; defense response to virus
Reference #:  Q13217 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ homolog subfamily C member 3; DNAJC3; DNJC3; FLJ21288; HP58; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; P58; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
Gene Symbols: DNAJC3
Molecular weight: 57,580 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNAJC3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K46-m2 KHLELGKkLLAAGQL
0 1 K96 AALPDLTKVIQLKMD
0 1 K133-u DDFKKVLkSNPSENE
0 1 K150-u EAQSQLIkSDEMQRL
0 2 K206 IKEGEPRKAISDLKA
0 1 K270 KQVKKLNKLIESAEE
0 2 K290-u RYTDATSkYESVMKT
0 1 K296 SkYESVMKTEPSIAE
0 1 K344 PDNVNALKDRAEAYL
0 6 K446-u FIDIAAAkEVLSDPE
  mouse

 
K46 KHLELGKKLLAAGQL
K96-u AALPDLTkVIALKMD
K133 DDFKKVLKSNPSEQE
K150 EAESQLVKADEMQRL
K206-a IKEGEPRkAISDLKA
K270-u KQVKKLNkLIESAEE
K290-u RYTDATSkYESVMkT
K296-u SkYESVMkTEPSVAE
K344-u PDNVNALkDRAEAYL
K446-u FIDIAAAkEVLSDPE
  rat

 
K46 KHLELGKKLLAAGQL
R96 AALPDLTRVIELKMD
K133 DDFKKVLKSNPSENE
K150 EAQSQLVKADEMQRL
K206 IKEGEPRKAISDLKA
K270 KQVKKLNKLIGSAEE
K290 RYTDATSKYESVMKA
K296 SKYESVMKAEPSVAE
K344 PDNVNALKDRAEAYL
K446 FIDIAAAKEVLSDPE
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