Home

GAD2 (human)

Overview GAD2 Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB. Protein type: EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - taurine and hypotaurine; Lyase; Carbohydrate Metabolism - butanoate Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; axon; plasma membrane; cytosol; cell junction Molecular Function: protein binding; glutamate decarboxylase activity; pyridoxal phosphate binding Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process Reference #:  Q05329 (UniProtKB) Alt. Names/Synonyms: 65 kDa glutamic acid decarboxylase; DCE2; GAD-65; GAD2; GAD65; Glutamate decarboxylase 2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); MGC161605; MGC161607 Gene Symbols: GAD2 Molecular weight: 65,411 Da Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GAD2 1ES0 - B=- (human) 2OKK - A=88-584 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1ES0 2OKK  |  ENZYME  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	2		S3-p	_____MAsPGsGFWs
1	0		S6-p	__MAsPGsGFWsFGs
1	1		S10-p	sPGsGFWsFGsEDGS
1	0		S13-p	sGFWsFGsEDGSGDS
0	1		K54	LLYGDAEKPAESGGS
0	1		S61	KPAESGGSQPPRAAA
0	8		K78-u	AACACDQkPCSCSKV
0	1		Y169-p	HCQTTLKyAIKTGHP
0	5		K286	EHSHFSLKKGAAALG
0	1		T515-p	YIPPSLRtLEDNEER
0	1		S546-p	EYGTTMVsyQPLGDK
0	1		Y547-p	YGTTMVsyQPLGDKV

	mouse
S3-p	_____MAsPGSGFWs
S6	__MAsPGSGFWsFGS
S10-p	sPGSGFWsFGSEDGS
S13	SGFWsFGSEDGSADP
K54-u	LLYGDSGkPAEGGGs
S61-p	kPAEGGGsVTSRAAT
K78-u	VACTCDQkPCNCPKG
Y169	HCQTTLKYAIKTGHP
K286-a	EHSHFSLkKGAAALG
T515	FVPPSLRTLEDNEER
S546	EYGTTMVSYQPLGDK
Y547	YGTTMVSYQPLGDKV

	rat
S3-p	_____MAsPGsGFWs
S6-p	__MAsPGsGFWsFGs
S10-p	sPGsGFWsFGsEDGS
S13-p	sGFWsFGsEDGSGDP
K54	LLYGDSEKPAESGGS
S61	KPAESGGSVTSRAAT
K78-u	VACTCDQkPCSCPKG
Y169	HCQTTLKYAIKTGHP
K286	EHSHFSLKKGAAALG
V515	FVPPSLRVLEDNEER
S546	EYGTTMVSYQPLGDK
Y547	YGTTMVSYQPLGDKV

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.