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Protein Page:
GAD2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GAD2 Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; Other Amino Acids Metabolism - taurine and hypotaurine; Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - beta-alanine; Lyase; EC 4.1.1.15
Cellular Component: presynaptic membrane; Golgi membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; axon; plasma membrane; cytosol; cell junction
Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding
Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; neurotransmitter biosynthetic process
Reference #:  Q05329 (UniProtKB)
Alt. Names/Synonyms: 65 kDa glutamic acid decarboxylase; DCE2; GAD-65; GAD2; GAD65; Glutamate decarboxylase 2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase-2 (pancreas); MGC161605; MGC161607
Gene Symbols: GAD2
Molecular weight: 65,411 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GAD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 2 S3-p _____MAsPGsGFWs
1 0 S6-p __MAsPGsGFWsFGs
1 1 S10-p sPGsGFWsFGsEDGS
1 0 S13-p sGFWsFGsEDGSGDS
0 1 K54 LLYGDAEKPAESGGS
0 1 S61 KPAESGGSQPPRAAA
0 8 K78 AACACDQKPCSCSKV
0 5 K286 EHSHFSLKKGAAALG
  mouse

 
S3-p _____MAsPGSGFWs
S6 __MAsPGSGFWsFGS
S10-p sPGSGFWsFGSEDGS
S13 SGFWsFGSEDGSADP
K54-u LLYGDSGkPAEGGGs
S61-p kPAEGGGsVTSRAAT
K78-u VACTCDQkPCNCPKG
K286-a EHSHFSLkKGAAALG
  rat

 
S3-p _____MAsPGsGFWs
S6-p __MAsPGsGFWsFGs
S10-p sPGsGFWsFGsEDGS
S13-p sGFWsFGsEDGSGDP
K54 LLYGDSEKPAESGGS
S61 KPAESGGSVTSRAAT
K78-u VACTCDQkPCSCPKG
K286 EHSHFSLKKGAAALG
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