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Protein Page:
TrkB (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Trk family
Cellular Component: cell surface; integral to plasma membrane; cell; dendrite; postsynaptic density; dendritic spine; integral to membrane; excitatory synapse; terminal button; cytosol; postsynaptic membrane; growth cone; cell soma; membrane; axon; presynaptic active zone; plasma membrane; nerve terminal; intracellular; endosome; receptor complex
Molecular Function: neurotrophin binding; protein homodimerization activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; protein kinase activity; transferase activity; brain-derived neurotrophic factor receptor activity; protein binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; regulation of dendrite development; neuron migration; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; regulation of metabolic process; negative regulation of neuron apoptosis; cell differentiation; vasculogenesis; regulation of Rac GTPase activity; neuromuscular junction development; central nervous system neuron development; nervous system development; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; long-term memory; glutamate secretion; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P15209 (UniProtKB)
Alt. Names/Synonyms: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; Ntrk2; Tkrb; Trk-B; Trkb; TrkB tyrosine kinase
Gene Symbols: Ntrk2
Molecular weight: 92,133 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y515‑p
cytoskeletal reorganization: S478‑p
enzymatic activity, induced: Y515‑p
molecular association, regulation: S478‑p
phosphorylation: Y515‑p
receptor internalization, altered: Y515‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 3 S141 HFRHLDLSDLILTGN
0 3 T151 ILTGNPFTCSCDIMW
0 3 S153 TGNPFTCSCDIMWLK
0 1 - gap
0 1 - gap
0 1 S476-p VISNDDDsAsPLHHI
2 1 S478-p SNDDDsAsPLHHISN
20 43 Y515-p PVIENPQyFGITNSQ
0 4 K524-u GITNSQLkPDTFVQH
0 5 Y557 KVFLAECYNLCPEQD
0 1 K571-u DKILVAVkTLKDASD
0 2 K690 VGENLLVKIGDFGMS
4 52 Y701-p FGMSRDVysTDyyRV
0 2 S702-p GMSRDVysTDyyRVG
9 51 Y705-p RDVysTDyyRVGGHT
7 30 Y706-p DVysTDyyRVGGHTM
0 5 Y782 RTCPQEVYELMLGCW
0 1 K800-u PHTRKNIkSIHTLLQ
1 0 K811 TLLQNLAKASPVyLD
6 0 Y816-p LAKASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso2  
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
K464-u RHSKFGMkGFVLFHk
K471-u kGFVLFHkIPLDG__
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  human

► Hide Isoforms
 
S141-p HFRHLDLsELILVGN
T151-p ILVGNPFtCsCDIMW
S153-p VGNPFtCsCDIMWIK
- gap
- gap
S477 VISNDDDSASPLHHI
S479 SNDDDSASPLHHISN
Y516-p PVIENPQyFGITNSQ
K525 GITNSQLKPDTFVQH
Y558-p KVFLAECyNLCPEQD
K572 DKILVAVKTLKDASD
K691 VGENLLVKIGDFGMS
Y702-p FGMSRDVySTDyyRV
S703 GMSRDVySTDyyRVG
Y706-p RDVySTDyyRVGGHT
Y707-p DVySTDyyRVGGHTM
Y783 RTCPQEVYELMLGCW
K801 PHMRKNIKGIHTLLQ
K812 TLLQNLAKASPVYLD
Y817 LAKASPVYLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso4  
S141 HFRHLDLSELILVGN
T151 ILVGNPFTCSCDIMW
S153 VGNPFTCSCDIMWIK
- gap
- gap
S493 VISNDDDSASPLHHI
S495 SNDDDSASPLHHISN
Y532 PVIENPQYFGITNSQ
K541 GITNSQLKPDTFVQH
Y574 KVFLAECYNLCPEQD
K588 DKILVAVKTLKDASD
K707 VGENLLVKIGDFGMS
Y718 FGMSRDVYSTDYYRV
S719 GMSRDVYSTDYYRVG
Y722 RDVYSTDYYRVGGHT
Y723 DVYSTDYYRVGGHTM
Y799 RTCPQEVYELMLGCW
K817 PHMRKNIKGIHTLLQ
K828 TLLQNLAKASPVYLD
Y833 LAKASPVYLDILG__
  rat

 
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
- gap
- gap
S476 VISNDDDSAsPLHHI
S478-p SNDDDSAsPLHHISN
Y515-p PVIENPQyFGITNSQ
K524-u GITNSQLkPDTFVQH
Y557-p KVFLAECyNLCPEQD
K571 DKILVAVKTLKDASD
K690-u VGENLLVkIGDFGMS
Y701-p FGMSRDVySTDyyRV
S702 GMSRDVySTDyyRVG
Y705-p RDVySTDyyRVGGHT
Y706-p DVySTDyyRVGGHTM
Y782-p RTCPQEVyELMLGCW
K800 PHTRKNIKNIHTLLQ
K811-u TLLQNLAkASPVyLD
Y816-p LAkASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
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