a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; Trk family
Cellular Component: cell surface; rough endoplasmic reticulum; cell; integral to plasma membrane; dendrite; postsynaptic density; dendritic spine; integral to membrane; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; cytoplasm; plasma membrane; presynaptic active zone; intracellular; nerve terminal; receptor complex; endosome
Molecular Function: neurotrophin binding; protein homodimerization activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; protein kinase activity; transferase activity; brain-derived neurotrophic factor receptor activity; protein binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; multicellular organismal development; protein amino acid autophosphorylation; regulation of dendrite development; regulation of neurotransmitter secretion; neuron migration; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; cell differentiation; vasculogenesis; regulation of Rac GTPase activity; neuromuscular junction development; central nervous system neuron development; nervous system development; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.