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Protein Page:
TrkB (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; TK group; Trk family
Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; dendrite; postsynaptic density; dendritic spine; integral to membrane; excitatory synapse; terminal button; perikaryon; cytosol; postsynaptic membrane; growth cone; membrane; cell soma; axon; cytoplasm; plasma membrane; presynaptic active zone; nerve terminal; intracellular; endosome; receptor complex
Molecular Function: brain-derived neurotrophic factor receptor activity; transferase activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding; protein kinase activity
Biological Process: mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; regulation of neurotransmitter secretion; neuron migration; regulation of dendrite development; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; regulation of metabolic process; negative regulation of neuron apoptosis; vasculogenesis; cell differentiation; regulation of Rac GTPase activity; neuromuscular junction development; central nervous system neuron development; nervous system development; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P15209 (UniProtKB)
Alt. Names/Synonyms: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; Ntrk2; Tkrb; Trk-B; Trkb; TrkB tyrosine kinase
Gene Symbols: Ntrk2
Molecular weight: 92,133 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
cell growth, altered: Y515‑p
cytoskeletal reorganization: S478‑p
enzymatic activity, induced: Y515‑p
molecular association, regulation: S478‑p
phosphorylation: Y515‑p
receptor internalization, altered: Y515‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 3 S141 HFRHLDLSDLILTGN
0 3 T151 ILTGNPFTCSCDIMW
0 3 S153 TGNPFTCSCDIMWLK
0 1 T161 CDIMWLKTLQETKSS
0 1 T253 TQGSLRITNISSDDS
0 1 S256 SLRITNISSDDSGKQ
0 1 S257 LRITNISSDDSGKQI
0 2 S260 TNISSDDSGKQISCV
0 1 K460 LKLARHSKFGMKGPA
0 1 - gap
0 1 - gap
0 1 S476-p VISNDDDsAsPLHHI
2 1 S478-p SNDDDsAsPLHHISN
0 1 T505 DAVIIGMTKIPVIEN
20 43 Y515-p PVIENPQyFGITNSQ
0 4 K524-ub GITNSQLkPDTFVQH
0 6 Y557 KVFLAECYNLCPEQD
0 1 K571-ub DKILVAVkTLKDASD
0 1 T572 KILVAVkTLKDASDN
0 2 K690 VGENLLVKIGDFGMS
4 55 Y701-p FGMSRDVysTDyyRV
0 2 S702-p GMSRDVysTDyyRVG
0 1 T703 MSRDVysTDyyRVGG
9 48 Y705-p RDVysTDyyRVGGHT
7 28 Y706-p DVysTDyyRVGGHTM
0 5 Y782 RTCPQEVYELMLGCW
0 1 K800-ub PHTRKNIkSIHTLLQ
1 0 K811 TLLQNLAKASPVyLD
6 0 Y816-p LAKASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso2  
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
T161 CDIMWLKTLQETKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K460 LKLARHSKFGMkGFV
K464-ub RHSKFGMkGFVLFHk
K471-ub kGFVLFHkIPLDG__
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  human

► Hide Isoforms
 
S141-p HFRHLDLsELILVGN
T151-p ILVGNPFtCsCDIMW
S153-p VGNPFtCsCDIMWIK
T161-p CDIMWIKtLQEAKSS
T253-p TQGSLRItNIssDDs
S256-p SLRItNIssDDsGKQ
S257-p LRItNIssDDsGKQI
S260-p tNIssDDsGKQISCV
K461-ac LKLARHSkFGMKGPA
- gap
- gap
S477 VISNDDDSASPLHHI
S479 SNDDDSASPLHHISN
T506-p DAVIIGMtKIPVIEN
Y516-p PVIENPQyFGITNSQ
K525 GITNSQLKPDTFVQH
Y558-p KVFLAECyNLCPEQD
K572 DKILVAVKtLKDASD
T573-p KILVAVKtLKDASDN
K691 VGENLLVKIGDFGMS
Y702-p FGMSRDVySTDyyRV
S703 GMSRDVySTDyyRVG
T704 MSRDVySTDyyRVGG
Y706-p RDVySTDyyRVGGHT
Y707-p DVySTDyyRVGGHTM
Y783 RTCPQEVYELMLGCW
K801 PHMRKNIKGIHTLLQ
K812 TLLQNLAKASPVYLD
Y817 LAKASPVYLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso4  
S141 HFRHLDLSELILVGN
T151 ILVGNPFTCSCDIMW
S153 VGNPFTCSCDIMWIK
T161 CDIMWIKTLQEAKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K461 LKLARHSKFGMKDFS
- gap
- gap
S493 VISNDDDSASPLHHI
S495 SNDDDSASPLHHISN
T522 DAVIIGMTKIPVIEN
Y532 PVIENPQYFGITNSQ
K541 GITNSQLKPDTFVQH
Y574 KVFLAECYNLCPEQD
K588 DKILVAVKTLKDASD
T589 KILVAVKTLKDASDN
K707 VGENLLVKIGDFGMS
Y718 FGMSRDVYSTDYYRV
S719 GMSRDVYSTDYYRVG
T720 MSRDVYSTDYYRVGG
Y722 RDVYSTDYYRVGGHT
Y723 DVYSTDYYRVGGHTM
Y799 RTCPQEVYELMLGCW
K817 PHMRKNIKGIHTLLQ
K828 TLLQNLAKASPVYLD
Y833 LAKASPVYLDILG__
  rat

 
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
T161 CDIMWLKTLQETKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K460 LKLARHSKFGMKGPA
- gap
- gap
S476 VISNDDDSAsPLHHI
S478-p SNDDDSAsPLHHISN
T505 DAVIIGMTKIPVIEN
Y515-p PVIENPQyFGITNSQ
K524-ub GITNSQLkPDTFVQH
Y557-p KVFLAECyNLCPEQD
K571 DKILVAVKTLKDASD
T572 KILVAVKTLKDASDN
K690-ub VGENLLVkIGDFGMS
Y701-p FGMSRDVyStDyyRV
S702 GMSRDVyStDyyRVG
T703-p MSRDVyStDyyRVGG
Y705-p RDVyStDyyRVGGHT
Y706-p DVyStDyyRVGGHTM
Y782-p RTCPQEVyELMLGCW
K800 PHTRKNIKNIHTLLQ
K811-ub TLLQNLAkASPVyLD
Y816-p LAkASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
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