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TrkB
a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Trk family |
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Cellular Component: cell surface; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; integral to membrane; terminal button; excitatory synapse; cytosol; growth cone; membrane; cell soma; axon; plasma membrane; presynaptic active zone; nerve terminal; intracellular; endosome
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Molecular Function: neurotrophin binding; protein homodimerization activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; protein kinase activity; transferase activity; brain-derived neurotrophic factor receptor activity; protein binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding
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Biological Process: mechanoreceptor differentiation; retinal rod cell development; protein amino acid autophosphorylation; multicellular organismal development; regulation of neurotransmitter secretion; neuron migration; regulation of dendrite development; protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; vasculogenesis; cell differentiation; regulation of Rac GTPase activity; central nervous system neuron development; nervous system development; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
P15209 (UniProtKB)
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| Alt. Names/Synonyms: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; Ntrk2; Tkrb; Trk-B; Trkb; TrkB tyrosine kinase |
| Gene Symbols: Ntrk2 |
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Molecular weight: 92,133 Da
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Basal Isoelectric point: 6.08
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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