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Protein Page:
TAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TAP1 a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Defects in TAP1 are a cause of bare lymphocyte syndrome. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; TAP complex; mitochondrion; membrane; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function: protein binding; protein homodimerization activity; peptide transporter activity; TAP1 binding; peptide antigen binding; MHC class I protein binding; ATPase activity, coupled to transmembrane movement of substances; TAP2 binding; ADP binding; ATP binding
Biological Process: ATP catabolic process; peptide transport; intracellular transport of viral proteins in host cell; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; defense response; antigen processing and presentation of endogenous peptide antigen via MHC class I; transmembrane transport; cytosol to ER transport
Reference #:  Q03518 (UniProtKB)
Alt. Names/Synonyms: ABC transporter, MHC 1; ABC17; ABCB2; Antigen peptide transporter 1; APT1; ATP-binding cassette sub-family B member 2; ATP-binding cassette, sub-family B (MDR/TAP), member 2; D6S114E; FLJ26666; FLJ41500; Peptide supply factor 1; Peptide transporter involved in antigen processing 1; Peptide transporter PSF1; Peptide transporter TAP1; PSF-1; PSF1; Really interesting new gene 4 protein; RING4; TAP1; TAP1*0102N; TAP1N; transporter 1, ATP-binding cassette, sub-family B; transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); transporter associated with antigen processing; transporter, ATP-binding cassette, major histocompatibility complex, 1; Y3
Gene Symbols: TAP1
Molecular weight: 87,218 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAP1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R30-m1 FPPPAASrGGLGGTr
0 1 R37-m1 rGGLGGTrSFRPHRG
0 1 Q338 QETEFFQQNQTGNIM
0 3 K422-ub QVRESLAkSSQVAIE
0 23 K449-ub NEEGEAQkFREKLQE
0 7 K458-ub REKLQEIkTLNQKEA
0 5 K537-ub KAVGSSEkIFEYLDR
0 6 T545-p IFEYLDRtPRCPPSG
0 1 C548 YLDRtPRCPPSGLLT
0 1 K627-ub GQLLLDGkPLPQYEH
0 1 K666-ub IAYGLTQkPTMEEIT
0 1 S748 VEQLLYESPERYSRS
  mouse

 
- gap
- gap
K254-ub QETGFFLkNPAGSIT
K338 KVQESLAKSTQVALE
K365-ub NEEGEAQkFRQKLEE
K374 RQKLEEMKTLNKKEA
K453-ub KAVGSSEkIFEYLDR
T461 IFEYLDRTPCsPLSG
S464-p YLDRTPCsPLSGSLA
Q543 GQLLLDGQCLVQYDH
T582 IAYGLNRTPTMEEIT
S664-p VQRLLYEsPKRASRT
  rat

 
- gap
- gap
K255 QETGFFLKNPTGSIT
K339 KVQESLAKSTQVALE
K366 NEEGEAQKFRQKLEE
K375 RQKLEEMKPLNKKEA
K454 KSVGASEKIFEYLDR
T462 IFEYLDRTPCSPLSG
S465 YLDRTPCSPLSGSLA
E544 GKVLLDGEPLVQYDH
T583 IAYGLTRTPTMEEIT
S665 VQRLLYESPEWASRT
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