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Protein Page:
TrkB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; Trk family
Cellular Component: postsynaptic membrane; cell surface; growth cone; cell soma; integral to plasma membrane; postsynaptic density; dendritic spine; presynaptic active zone; excitatory synapse; terminal button; endosome membrane; cytosol; receptor complex
Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; ATP binding
Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of dendrite development; neuron migration; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; vasculogenesis; regulation of Rac GTPase activity; neuromuscular junction development; central nervous system neuron development; aging; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; glutamate secretion; long-term memory; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q16620 (UniProtKB)
Alt. Names/Synonyms: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; Trk-B; TRKB; TrkB tyrosine kinase; tyrosine kinase receptor B
Gene Symbols: NTRK2
Molecular weight: 91,999 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkB

Protein Structure Not Found.

Substrate Sequence Logo
Sequence Logo

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Sites Implicated In
phosphorylation: Y706‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S141-p HFRHLDLsELILVGN
0 3 T151-p ILVGNPFtCsCDIMW
0 3 S153-p VGNPFtCsCDIMWIK
0 1 T161-p CDIMWIKtLQEAKSS
0 1 T253-p TQGSLRItNIssDDs
0 1 S256-p SLRItNIssDDsGKQ
0 1 S257-p LRItNIssDDsGKQI
0 2 S260-p tNIssDDsGKQISCV
0 1 K461-ac LKLARHSkFGMKGPA
0 1 - gap
0 1 - gap
0 1 S477 VISNDDDSASPLHHI
2 1 S479 SNDDDSASPLHHISN
0 1 T506-p DAVIIGMtKIPVIEN
20 43 Y516-p PVIENPQyFGITNSQ
0 4 K525 GITNSQLKPDTFVQH
0 6 Y558-p KVFLAECyNLCPEQD
0 1 K572 DKILVAVKtLKDASD
0 1 T573-p KILVAVKtLKDASDN
0 2 K691 VGENLLVKIGDFGMS
4 55 Y702-p FGMSRDVySTDyyRV
0 2 S703 GMSRDVySTDyyRVG
0 1 T704 MSRDVySTDyyRVGG
9 48 Y706-p RDVySTDyyRVGGHT
7 28 Y707-p DVySTDyyRVGGHTM
0 5 Y783 RTCPQEVYELMLGCW
0 1 K801 PHMRKNIKGIHTLLQ
1 0 K812 TLLQNLAKASPVYLD
6 0 Y817 LAKASPVYLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso4  
S141 HFRHLDLSELILVGN
T151 ILVGNPFTCSCDIMW
S153 VGNPFTCSCDIMWIK
T161 CDIMWIKTLQEAKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K461 LKLARHSKFGMKDFS
- gap
- gap
S493 VISNDDDSASPLHHI
S495 SNDDDSASPLHHISN
T522 DAVIIGMTKIPVIEN
Y532 PVIENPQYFGITNSQ
K541 GITNSQLKPDTFVQH
Y574 KVFLAECYNLCPEQD
K588 DKILVAVKTLKDASD
T589 KILVAVKTLKDASDN
K707 VGENLLVKIGDFGMS
Y718 FGMSRDVYSTDYYRV
S719 GMSRDVYSTDYYRVG
T720 MSRDVYSTDYYRVGG
Y722 RDVYSTDYYRVGGHT
Y723 DVYSTDYYRVGGHTM
Y799 RTCPQEVYELMLGCW
K817 PHMRKNIKGIHTLLQ
K828 TLLQNLAKASPVYLD
Y833 LAKASPVYLDILG__
  mouse

► Hide Isoforms
 
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
T161 CDIMWLKTLQETKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K460 LKLARHSKFGMKGPA
- gap
- gap
S476-p VISNDDDsAsPLHHI
S478-p SNDDDsAsPLHHISN
T505 DAVIIGMTKIPVIEN
Y515-p PVIENPQyFGITNSQ
K524-ub GITNSQLkPDTFVQH
Y557 KVFLAECYNLCPEQD
K571-ub DKILVAVkTLKDASD
T572 KILVAVkTLKDASDN
K690 VGENLLVKIGDFGMS
Y701-p FGMSRDVysTDyyRV
S702-p GMSRDVysTDyyRVG
T703 MSRDVysTDyyRVGG
Y705-p RDVysTDyyRVGGHT
Y706-p DVysTDyyRVGGHTM
Y782 RTCPQEVYELMLGCW
K800-ub PHTRKNIkSIHTLLQ
K811 TLLQNLAKASPVyLD
Y816-p LAKASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
  TrkB iso2  
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
T161 CDIMWLKTLQETKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K460 LKLARHSKFGMkGFV
K464-ub RHSKFGMkGFVLFHk
K471-ub kGFVLFHkIPLDG__
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
S141 HFRHLDLSDLILTGN
T151 ILTGNPFTCSCDIMW
S153 TGNPFTCSCDIMWLK
T161 CDIMWLKTLQETKSS
T253 TQGSLRITNISSDDS
S256 SLRITNISSDDSGKQ
S257 LRITNISSDDSGKQI
S260 TNISSDDSGKQISCV
K460 LKLARHSKFGMKGPA
- gap
- gap
S476 VISNDDDSAsPLHHI
S478-p SNDDDSAsPLHHISN
T505 DAVIIGMTKIPVIEN
Y515-p PVIENPQyFGITNSQ
K524-ub GITNSQLkPDTFVQH
Y557-p KVFLAECyNLCPEQD
K571 DKILVAVKTLKDASD
T572 KILVAVKTLKDASDN
K690-ub VGENLLVkIGDFGMS
Y701-p FGMSRDVyStDyyRV
S702 GMSRDVyStDyyRVG
T703-p MSRDVyStDyyRVGG
Y705-p RDVyStDyyRVGGHT
Y706-p DVyStDyyRVGGHTM
Y782-p RTCPQEVyELMLGCW
K800 PHTRKNIKNIHTLLQ
K811-ub TLLQNLAkASPVyLD
Y816-p LAkASPVyLDILG__
4619 : Phospho-TrkA (Tyr490)/TrkB (Tyr516) (C35G9) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4621 : Phospho-TrkA (Tyr674/675)/TrkB (Tyr706/707) (C50F3) Rabbit mAb
4168 : Phospho-TrkA (Tyr785)/TrkB (Tyr816) (C67C8) Rabbit mAb
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