a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; EC 188.8.131.52; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Trk family
Cellular Component: Golgi membrane; growth cone; cell surface; cell soma; integral to plasma membrane; postsynaptic density; presynaptic active zone; excitatory synapse; terminal button; endosome membrane; cytosol
Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; brain-derived neurotrophic factor binding; ATP binding
Biological Process: mechanoreceptor differentiation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of dendrite development; regulation of neurotransmitter secretion; neuron migration; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; vasculogenesis; regulation of Rac GTPase activity; central nervous system neuron development; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.