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TrkB (human)

Overview TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Trk family Cellular Component: Golgi membrane; growth cone; cell surface; cell soma; integral to plasma membrane; postsynaptic density; presynaptic active zone; excitatory synapse; terminal button; endosome membrane; cytosol Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; brain-derived neurotrophic factor binding; ATP binding Biological Process: mechanoreceptor differentiation; retinal rod cell development; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of dendrite development; regulation of neurotransmitter secretion; neuron migration; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; vasculogenesis; regulation of Rac GTPase activity; central nervous system neuron development; brain-derived neurotrophic factor receptor signaling pathway; adenylate cyclase activation; regulation of protein kinase B signaling cascade; learning; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; glutamate secretion; positive regulation of axonogenesis; cerebral cortex development; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  Q16620 (UniProtKB) Alt. Names/Synonyms: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; Trk-B; TRKB; TrkB tyrosine kinase; tyrosine kinase receptor B Gene Symbols: NTRK2 Molecular weight: 91,999 Da Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TrkB 1HCF - X/Y=284-383 (human) 1WWB - X=283-385 (human) 4ASZ - A=543-838 (human) 4AT3 - A=543-838 (human) 4AT4 - A=543-838 (human) 4AT5 - A=543-838 (human) Substrate Sequence Logo

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
phosphorylation: Y706‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	3		S141-p	HFRHLDLsELILVGN
0	3		T151-p	ILVGNPFtCsCDIMW
0	3		S153-p	VGNPFtCsCDIMWIK
0	1		T161-p	CDIMWIKtLQEAKSS
0	1		S260-p	TNISSDDsGKQISCV
0	1		K461-a	LKLARHSkFGMKGPA
0	1		-	gap
0	1		-	gap
0	1		S477	VISNDDDSASPLHHI
2	1		S479	SNDDDSASPLHHISN
0	1		T506-p	DAVIIGMtKIPVIEN
20	43		Y516-p	PVIENPQyFGITNSQ
0	4		K525	GITNSQLKPDTFVQH
0	5		Y558-p	KVFLAECyNLCPEQD
0	1		K572	DKILVAVKtLKDASD
0	1		T573-p	KILVAVKtLKDASDN
0	2		K691	VGENLLVKIGDFGMS
4	52		Y702-p	FGMSRDVySTDyyRV
0	2		S703	GMSRDVySTDyyRVG
9	51		Y706-p	RDVySTDyyRVGGHT
7	30		Y707-p	DVySTDyyRVGGHTM
0	5		Y783-p	RTCPQEVyELMLGCW
0	1		K801	PHMRKNIKGIHTLLQ
1	0		K812	TLLQNLAKASPVYLD
6	0		Y817	LAKASPVYLDILG__

	TrkB iso4
S141	HFRHLDLSELILVGN
T151	ILVGNPFTCSCDIMW
S153	VGNPFTCSCDIMWIK
T161	CDIMWIKTLQEAKSS
S260	TNISSDDSGKQISCV
K461	LKLARHSKFGMKDFS
-	gap
-	gap
S493	VISNDDDSASPLHHI
S495	SNDDDSASPLHHISN
T522	DAVIIGMTKIPVIEN
Y532	PVIENPQYFGITNSQ
K541	GITNSQLKPDTFVQH
Y574	KVFLAECYNLCPEQD
K588	DKILVAVKTLKDASD
T589	KILVAVKTLKDASDN
K707	VGENLLVKIGDFGMS
Y718	FGMSRDVYSTDYYRV
S719	GMSRDVYSTDYYRVG
Y722	RDVYSTDYYRVGGHT
Y723	DVYSTDYYRVGGHTM
Y799	RTCPQEVYELMLGCW
K817	PHMRKNIKGIHTLLQ
K828	TLLQNLAKASPVYLD
Y833	LAKASPVYLDILG__

	mouse ► Hide Isoforms
S141	HFRHLDLSDLILTGN
T151	ILTGNPFTCSCDIMW
S153	TGNPFTCSCDIMWLK
T161	CDIMWLKTLQETKSS
S260	TNISSDDSGKQISCV
K460	LKLARHSKFGMKGPA
-	gap
-	gap
S476-p	VISNDDDsAsPLHHI
S478-p	SNDDDsAsPLHHISN
T505	DAVIIGMTKIPVIEN
Y515-p	PVIENPQyFGITNSQ
K524-u	GITNSQLkPDTFVQH
Y557	KVFLAECYNLCPEQD
K571-u	DKILVAVkTLKDASD
T572	KILVAVkTLKDASDN
K690	VGENLLVKIGDFGMS
Y701-p	FGMSRDVysTDyyRV
S702-p	GMSRDVysTDyyRVG
Y705-p	RDVysTDyyRVGGHT
Y706-p	DVysTDyyRVGGHTM
Y782	RTCPQEVYELMLGCW
K800-u	PHTRKNIkSIHTLLQ
K811	TLLQNLAKASPVyLD
Y816-p	LAKASPVyLDILG__

	TrkB iso2
S141	HFRHLDLSDLILTGN
T151	ILTGNPFTCSCDIMW
S153	TGNPFTCSCDIMWLK
T161	CDIMWLKTLQETKSS
S260	TNISSDDSGKQISCV
K460	LKLARHSKFGMkGFV
K464-u	RHSKFGMkGFVLFHk
K471-u	kGFVLFHkIPLDG__
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	rat
S141	HFRHLDLSDLILTGN
T151	ILTGNPFTCSCDIMW
S153	TGNPFTCSCDIMWLK
T161	CDIMWLKTLQETKSS
S260	TNISSDDSGKQISCV
K460	LKLARHSKFGMKGPA
-	gap
-	gap
S476	VISNDDDSAsPLHHI
S478-p	SNDDDSAsPLHHISN
T505	DAVIIGMTKIPVIEN
Y515-p	PVIENPQyFGITNSQ
K524-u	GITNSQLkPDTFVQH
Y557-p	KVFLAECyNLCPEQD
K571	DKILVAVKTLKDASD
T572	KILVAVKTLKDASDN
K690-u	VGENLLVkIGDFGMS
Y701-p	FGMSRDVySTDyyRV
S702	GMSRDVySTDyyRVG
Y705-p	RDVySTDyyRVGGHT
Y706-p	DVySTDyyRVGGHTM
Y782-p	RTCPQEVyELMLGCW
K800	PHTRKNIKNIHTLLQ
K811-u	TLLQNLAkASPVyLD
Y816-p	LAkASPVyLDILG__

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