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Protein Page:
NPEPPS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NPEPPS Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. Belongs to the peptidase M1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.11.-; Protease; EC 3.4.11.14
Cellular Component: nucleus; cytosol
Molecular Function: metallopeptidase activity; zinc ion binding; aminopeptidase activity
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; protein polyubiquitination; proteolysis
Reference #:  P55786 (UniProtKB)
Alt. Names/Synonyms: AAP-S; AAPS; aminopeptidase puromycin sensitive; metalloproteinase MP100; MP100; NPEPPS; PSA; Puromycin-sensitive aminopeptidase
Gene Symbols: NPEPPS
Molecular weight: 103,276 Da
Basal Isoelectric point: 5.49  Predict pI for various phosphorylation states
Select Structure to View Below

NPEPPS

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K68-ub INYSLCLkPDLLDFT
0 2 K79-ub LDFTFEGkLEAAAQV
0 6 K155-ub FVGELNDkMkGFYRS
0 1 K157-ub GELNDkMkGFYRSKY
0 1 T177 EVRYAAVTQFEATDA
0 1 T182 AVTQFEATDARRAFP
0 2 K208-ub DISLVVPkDRVALsN
0 1 S214-p PkDRVALsNMNVIDR
0 3 K234-ub DENLVEVkFARTPVM
0 1 K261 DFVETRSKDGVCVRV
0 2 K274-ub RVYTPVGkAEQGKFA
0 3 K459-ac IGDKDFKkGMNMYLT
0 2 K467-ub GMNMYLTkFQQKNAA
0 1 K563 KLKILMDKPEMNVVL
0 1 K574 NVVLKNVKPDQWVKL
0 1 S594-p GFYRTQYsSAMLESL
0 1 S609-p LPGIRDLsLPPVDRL
0 1 S684 EFVKDVFSPIGERLG
0 4 S745-p ILSADLRsPVYLTVL
0 1 L788 RVLGATLLPDLIQKV
0 1 K829-ub HGRKAAWkFIkDNWE
0 1 K832-ac KAAWkFIkDNWEELY
0 1 S904 WLKRDAESIHQYLLQ
0 1 A914 QYLLQRKASPPTV__
0 3 S915 YLLQRKASPPTV___
0 1 T918 QRKASPPTV______
  mouse

 
K69 INYSLCLKPDLLDFT
K80-ub LDFTFEGkLEAAAQV
K156-ub FVGELNDkMKGFYRS
K158 GELNDkMKGFYRSRY
T178-p EVRYAAVtQFEAtDA
T183-p AVtQFEAtDARRAFP
K209-ub DISLVVPkDRVALSN
S215 PkDRVALSNMNVIDR
K235 DENLVEVKFARTPVM
K262-ub DFVETRSkDGVCVRV
K275-ub RVYTPVGkAEQGKFA
K460 IGDKDFKKGMNMYLT
K468-ub GMNMYLTkFQQKNAA
K564-ub KLKILMDkPEMSVVL
K575-ub SVVLKNVkPDQWVKL
S595 GFYRTQYSSAMLESL
S610 LPGIRDLSLPPVDRL
S685-p EFVKDVFsPIGERLG
S746-p ILSADLRsPVYLTVL
S789-p RVLGATLsPELIQKV
K830 HGRKAAWKFIkDNWE
K833-ac KAAWKFIkDNWEELH
S905-p WLKRDADsIHQYLLQ
T915-p QYLLQRKtsPPsV__
S916-p YLLQRKtsPPsV___
S919-p QRKtsPPsV______
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