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Protein Page:
SUCLG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SUCLG1 Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity. Heterodimer of an alpha and a beta subunit. Belongs to the succinate/malate CoA ligase alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Ligase; EC 6.2.1.5; EC 6.2.1.4; Mitochondrial
Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane
Molecular Function: succinate-CoA ligase (GDP-forming) activity; GDP binding; GTP binding; ATP citrate synthase activity; protein heterodimerization activity; cofactor binding; succinate-CoA ligase (ADP-forming) activity
Biological Process: succinate metabolic process; cellular metabolic process; succinyl-CoA metabolic process; tricarboxylic acid cycle
Reference #:  P53597 (UniProtKB)
Alt. Names/Synonyms: FLJ21114; FLJ43513; GALPHA; SCS-alpha; SUCA; succinate-CoA ligase, alpha subunit; Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase subunit alpha; SUCLA1; SUCLG1
Gene Symbols: SUCLG1
Molecular weight: 36,250 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SUCLG1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2 ______MTATLAAAA
0 4 K54-ac RQHLYVDkNTKIICQ
0 1 K54-sc RQHLYVDkNTKIICQ
0 2 K57 LYVDkNTKIICQGFT
0 1 K57 LYVDkNTKIICQGFT
0 1 K57 LYVDkNTKIICQGFT
0 2 K66 ICQGFTGKQGtFHSQ
0 2 K66-ub ICQGFTGkQGtFHSQ
0 1 K66 ICQGFTGKQGtFHSQ
0 1 T69-p GFTGkQGtFHSQQAL
0 1 K81 QALEYGTKLVGGTTP
0 1 K81 QALEYGTKLVGGTTP
0 2 K90 VGGTTPGKGGQTHLG
0 1 K90 VGGTTPGKGGQTHLG
0 3 T94 TPGKGGQTHLGLPVF
0 1 T94 TPGKGGQTHLGLPVF
0 1 T94 TPGKGGQTHLGLPVF
0 1 K105 LPVFNTVKEAKEQTG
0 1 K105 LPVFNTVKEAKEQTG
0 3 K164 HKLLRQEKTRLIGPN
0 42 K192-ac IMPGHIHkKGRIGIV
0 3 K193 MPGHIHkKGRIGIVS
0 2 K280 HNSGPNSKPVVSFIA
0 10 K308-ac GAIIAGGkGGAkEKI
0 5 K312-ac AGGkGGAkEKISALQ
0 1 K314 GkGGAkEKISALQsA
0 1 S320-p EKISALQsAGVVVSM
0 3 K338 QLGTTIYKEFEKRKM
0 1 K338 QLGTTIYKEFEKRKM
0 6 K342 TIYKEFEKRKML___
  mouse

 
T2-p ______MtATVVAAA
K54-ac RKHIYIDkNTkIICQ
K54-sc RKHIYIDkNTkIICQ
K57-ac IYIDkNTkIICQGFT
K57-ub IYIDkNTkIICQGFT
K57-sc IYIDkNTkIICQGFT
K66-ac ICQGFTGkQGTFHSQ
K66-ub ICQGFTGkQGTFHSQ
K66-sc ICQGFTGkQGTFHSQ
T69 GFTGkQGTFHSQQAL
K81-ac QALEYGTkLVGGTTP
K81-sc QALEYGTkLVGGTTP
K90-ac VGGTTPGkGGQkHLG
K90-ub VGGTTPGkGGQkHLG
K94-ac TPGkGGQkHLGLPVF
K94-ub TPGkGGQkHLGLPVF
K94-sc TPGkGGQkHLGLPVF
K105-ac LPVFNTVkEAKEKTG
K105-sc LPVFNTVkEAKEKTG
T164-p HRLTRQGtTRLIGPN
K192-ac IMPGHIHkkGRIGIV
K193-ac MPGHIHkkGRIGIVS
K280-ub HNSGPKAkPVVSFIA
K308-ac GAIIAGGkGGAkEkI
K312-ac AGGkGGAkEkISALQ
K314-ac GkGGAkEkISALQSA
S320 EkISALQSAGVVVSM
K338-ac QLGTTIYkEFEkRKM
K338-sc QLGTTIYkEFEkRKM
K342-ac TIYkEFEkRKML___
  rat

 
T2 ______MTAAVVAAA
K54-ac RKNIYIDkNTkVICQ
K54 RKNIYIDKNTkVICQ
K57-ac IYIDkNTkVICQGFT
K57 IYIDkNTKVICQGFT
K57 IYIDkNTKVICQGFT
K66-ac ICQGFTGkQGTFHSQ
K66 ICQGFTGKQGTFHSQ
K66 ICQGFTGKQGTFHSQ
T69 GFTGkQGTFHSQQAL
K81-ac QALEYGTkLVGGTTP
K81 QALEYGTKLVGGTTP
K90 VGGTTPGKGGKKHLG
K90 VGGTTPGKGGKKHLG
K94 TPGKGGKKHLGLPVF
K94 TPGKGGKKHLGLPVF
K94 TPGKGGKKHLGLPVF
K105-ac LPVFNTVkEAKEKTG
K105 LPVFNTVKEAKEKTG
K164 HKLTRQGKTRLIGPN
K192-ac IMPGHIHkKGRIGIV
K193 MPGHIHkKGRIGIVS
K280 HNSGPKAKPVVSFIA
K308 GAIIAGGKGGAKEKI
K312 AGGKGGAKEKISALQ
K314 GKGGAKEKISALQSA
S320 EKISALQSAGVIVSM
K338 QLGTCMYKEFEkRKM
K338 QLGTCMYKEFEkRKM
K342-ac CMYKEFEkRKML___
  pig

 
T2 ______MTAALVAAP
K54 RKHLYVDKNTKVICQ
K54 RKHLYVDKNTKVICQ
K57 LYVDKNTKVICQGFT
K57 LYVDKNTKVICQGFT
K57 LYVDKNTKVICQGFT
K66 ICQGFTGKQGTFHSQ
K66 ICQGFTGKQGTFHSQ
K66 ICQGFTGKQGTFHSQ
T69 GFTGKQGTFHSQQAL
N81 QALEYGTNLVGGTTP
N81 QALEYGTNLVGGTTP
K90 VGGTTPGKGGKTHLG
K90 VGGTTPGKGGKTHLG
T94 TPGKGGKTHLGLPVF
T94 TPGKGGKTHLGLPVF
T94 TPGKGGKTHLGLPVF
K105 LPVFNTVKEAKEQTG
K105 LPVFNTVKEAKEQTG
K164 HRLLRQGKTRLIGPN
K192 IMPGHIHKKGRIGIV
K193 MPGHIHKKGRIGIVS
K280 HNSGPKSKPVVSFIA
K308 GAIIAGGKGGAKEKI
K312 AGGKGGAKEKITALQ
K314 GKGGAKEKITALQSA
S320 EKITALQSAGVVVSM
K338 QLGTTIYKEFEKRKM
K338 QLGTTIYKEFEKRKM
K342 TIYKEFEKRKML___
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