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LRPAP1 (human)

Overview LRPAP1 Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. Note: This description may include information from UniProtKB. Protein type: Receptor, misc. Cellular Component: cell surface; endoplasmic reticulum; extracellular region; integral to membrane; plasma membrane; vesicle Molecular Function: heparin binding; receptor antagonist activity; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity Biological Process: vesicle-mediated transport; protein folding; negative regulation of protein binding Reference #:  P30533 (UniProtKB) Alt. Names/Synonyms: A2MRAP; A2RAP; Alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein 1; Alpha-2-MRAP; AMRP; HBP44; lipoprotein receptor associated protein; low density lipoprotein receptor-related protein associated protein 1; Low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); LRPAP1; MGC138272; MRAP; RAP Gene Symbols: LRPAP1 Molecular weight: 41,466 Da Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states

Select Structure to View Below LRPAP1 1LRE - A=51-131 (human) 1NRE - A=51-131 (human) 1OP1 - A=51-132 (human) 1OV2 - A=35-133 (human) 2FCW - A=250-357 (human) 2FTU - A=240-357 (human) 2FYL - A=51-131 (human) 2P01 - A=35-357 (human) 2P03 - A=35-357 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03  |  Phospho3D  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S45-p	EKNQPKPsPKREsGE
0	3		S50-p	KPsPKREsGEEFRME
0	1		K128	KYGLDGKKDARQVTs
0	2		S135-p	KDARQVTsNsLSGtQ
0	1		S137-p	ARQVTsNsLSGtQED
0	1		T141-p	TsNsLSGtQEDGLDD
0	1		G166	KTSGKFSGEELDKLW
0	1		K182	EFLHHKEKVHEYNVL
0	1		S230-p	ELKEKLRsINQGLDR
1	1		S242	LDRLRRVSHQGYstE
0	1		S247-p	RVSHQGYstEAEFEE
0	1		T248-p	VSHQGYstEAEFEEP
0	1		K287-a	ELKHFEAkIEKHNHY
0	1		K323	RVSRSREKHALLEGR
0	1		K332-u	ALLEGRTkELGyTVK
0	1		Y336-p	GRTkELGyTVKKHLQ

	mouse
A48	EKNEPEMAAKREsGE
S53-p	EMAAKREsGEEFRME
K131-u	RYGLDGRkDAQMVHs
S138-p	kDAQMVHsNALNEDT
A140	AQMVHsNALNEDTQD
-	under review
S169-p	KTSGKFSsEELDKLW
K185-u	EFLHYKEkIQEYNVL
S233	ELKDRLRSINQGLDR
S245	LDRLRKVSHQGYGST
G250	KVSHQGYGSTTEFEE
S251	VSHQGYGSTTEFEEP
K290	ELKHFEAKIEKHNHY
K326-a	HISRNKEkYVLLEEK
K335	VLLEEKTKELGYKVK
Y339	EKTKELGYKVKKHLQ

	rat
A48	EKNEPEMAAKRESGE
S53	EMAAKRESGEEFRME
K131	RYGLDGRKDTQTVHS
S138	KDTQTVHSNALNEDT
A140	TQTVHSNALNEDTQD
-	under review
S169	KTSGKFSSEELDKLW
K185	EFLHYKEKIHEYNVL
S233	ELKDRLRSINQGLDR
S245-p	LDRLRKVsHQGYGPA
G250	KVsHQGYGPATEFEE
P251	VsHQGYGPATEFEEP
K290	ELKHFEAKIEKHNHY
K326	HISRNKEKYVLLEEK
K335	VLLEEKTKELGYKVK
Y339	EKTKELGYKVKKHLQ

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