Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Motility/polarity/chemotaxis
Cellular Component: nucleus
Molecular Function: p53 binding; sequence-specific DNA binding; transcription factor activity
Biological Process: apoptotic nuclear changes; protein stabilization; transcription, DNA-dependent; cell morphogenesis; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of histone acetylation; odontogenesis of dentine-containing teeth
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.