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MSX1
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; DNA binding protein |
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Cellular Component: transcription factor complex; nucleus
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Molecular Function: sequence-specific DNA binding; p53 binding
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Biological Process: negative regulation of striated muscle cell differentiation; embryonic forelimb morphogenesis; muscle development; positive regulation of apoptosis; mesenchymal cell proliferation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; palate development; embryonic hindlimb morphogenesis; anterior/posterior pattern formation; negative regulation of cell proliferation; forebrain development; midbrain development; positive regulation of BMP signaling pathway; protein stabilization; regulation of odontogenesis; in utero embryonic development; stem cell differentiation; odontogenesis of dentine-containing teeth; apoptotic nuclear changes; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptosis
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Reference #:
P28360 (UniProtKB)
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| Alt. Names/Synonyms: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; HOX7; HYD1; msh homeo box 1; msh homeobox 1; Msh homeobox 1-like protein; msh homeobox homolog 1; MSX1; STHAG1 |
| Gene Symbols: MSX1 |
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Molecular weight: 30,940 Da
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Basal Isoelectric point: 9.96
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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