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Protein Page:
MSX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MSX1 Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; DNA binding protein
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: sequence-specific DNA binding; p53 binding
Biological Process: negative regulation of striated muscle cell differentiation; embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; muscle development; protein stabilization; in utero embryonic development; regulation of odontogenesis; mesenchymal cell proliferation; cell morphogenesis; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; palate development; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of BMP signaling pathway; negative regulation of apoptosis
Reference #:  P28360 (UniProtKB)
Alt. Names/Synonyms: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; HOX7; HYD1; msh homeo box 1; msh homeobox 1; Msh homeobox 1-like protein; msh homeobox homolog 1; MSX1; STHAG1
Gene Symbols: MSX1
Molecular weight: 31,496 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MSX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K15 TSLPLGVKVEDSAFG
1 0 K133 LPEDALVKAESPEKP
0 1 R150 TPWMQSPRFSPPPAR
0 1 R157 RFSPPPARRLSPPAC
0 1 T180-p RKPRTPFtTAQLLAL
  mouse

 
K15-sm TSLPLGVkVEDSAFA
K133-sm LPEDALVkAESPEKL
R150-m2 TPWMQSPrFSPPPAr
R157-m2 rFSPPPArRLSPPAC
T180 RKPRTPFTTAQLLAL
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