Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Motility/polarity/chemotaxis
Molecular Function: sequence-specific DNA binding; p53 binding
Biological Process: transcription from RNA polymerase II promoter; embryonic forelimb morphogenesis; negative regulation of striated muscle cell differentiation; muscle development; protein stabilization; regulation of odontogenesis; in utero embryonic development; mesenchymal cell proliferation; cell morphogenesis; middle ear morphogenesis; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; odontogenesis of dentine-containing teeth; anterior/posterior pattern formation; negative regulation of cell proliferation; pituitary gland development; midbrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of cell growth; positive regulation of BMP signaling pathway; negative regulation of apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.