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Protein Page:
NR2F2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NR2F2 Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; Motility/polarity/chemotaxis; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; retinoic acid binding; protein homodimerization activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription factor activity
Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cyclin-dependent protein kinase activity; neuron migration; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; fertilization; negative regulation of endothelial cell proliferation; forebrain development; blood vessel morphogenesis; steroid hormone mediated signaling; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation; maternal placenta development
Reference #:  P24468 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor related protein 1; Apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; ARP1; chicken ovalbumin upstream promoter transcription factor 2; COT2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPTFB; COUPTFII; MGC117452; NR2F2; Nuclear receptor subfamily 2 group F member 2; nuclear receptor subfamily 2, group F, member 2; SVP40; TFCOUP2
Gene Symbols: NR2F2
Molecular weight: 45,571 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NR2F2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T39-p PPPGAPHtPQTPGQG
0 1 T51-p GQGGPAStPAQTAAG
0 2 Y348-p SQCALEEyVRSQYPN
0 3 K389-ub FFVRLVGkTPIETLI
  mouse

 
T39 PPPGAPHTPQTPGQG
T51 GQGGPASTPAQTAAG
Y348-p SQCALEEyVRSQYPN
K389-ub FFVRLVGkTPIETLI
  rat

 
T39 PPPGAPHTPQTPGQG
T51 GQGGPASTPAQTAAG
Y348 SQCALEEYVRSQYPN
K389 FFVRLVGKTPIETLI
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