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NR2F2 (human)

Overview NR2F2 Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Nuclear receptor; DNA binding protein Cellular Component: nucleus Molecular Function: protein binding; ligand-dependent nuclear receptor activity; retinoic acid binding; protein homodimerization activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; transcription factor activity Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; negative regulation of endothelial cell proliferation; forebrain development; blood vessel morphogenesis; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation Reference #:  P24468 (UniProtKB) Alt. Names/Synonyms: ADP-ribosylation factor related protein 1; Apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; ARP1; chicken ovalbumin upstream promoter transcription factor 2; COT2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPTFB; COUPTFII; MGC117452; NR2F2; Nuclear receptor subfamily 2 group F member 2; nuclear receptor subfamily 2, group F, member 2; SVP40; TFCOUP2 Gene Symbols: NR2F2 Molecular weight: 45,571 Da Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NR2F2 3CJW - A=173-412 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y348-p	SQCALEEyVRSQYPN
0	3		K389-u	FFVRLVGkTPIETLI

	mouse
Y348-p	SQCALEEyVRSQYPN
K389-u	FFVRLVGkTPIETLI

	rat
Y348	SQCALEEYVRSQYPN
K389	FFVRLVGKTPIETLI

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