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SCF (human)

Overview SCF Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: extracellular space; cytoskeleton; cytoplasm; integral to membrane; extracellular region; plasma membrane Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding Biological Process: embryonic hemopoiesis; male gonad development; germ cell programmed cell death; signal transduction; positive regulation of MAP kinase activity; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; ovarian follicle development; negative regulation of mast cell apoptosis; positive regulation of melanocyte differentiation; hemopoiesis; positive regulation of Ras protein signal transduction; positive regulation of myeloid leukocyte differentiation; cell adhesion; neural crest cell migration; positive regulation of DNA replication Reference #:  P21583 (UniProtKB) Alt. Names/Synonyms: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; steel factor; Stem cell factor Gene Symbols: KITLG Molecular weight: 30,899 Da Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  Cell Cycle: G2/M DNA Damage Checkpoint Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SCF 1EXZ - A/B/C/D=26-166 (human) 1SCF - A/B/C/D=1-273 (human) 2E9W - C/D=26-166 (human) 2O26 - B/E/F=28-166 (mouse) 2O27 - A/B=28-166 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1EXZ 1SCF 2E9W  |  Phospho3D  |  DISEASE 184745 611664  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S147	FFRIFNRSIDAFKDF
0	1		S158	FKDFVVASETSDCVV
0	1		K181-u	DSRVSVTkPFMLPPV
0	1		K266-u	EISMLQEkEREFQEV

	mouse
S147	FFSIFNRSIDAFKDF
S158	FKDFMVASDTSDCVL
K181	DSRVSVTKPFMLPPV
K266	EISMLQQKEREFQEV

	rat
S147-p	FFSIFNRsIDAFKDF
S158-p	FKDFMVAsDTSDCVL
K181	DSRVSVTKPFMLPPV
K266	EISMLQQKEREFQEV

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