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Protein Page:
NPY (human)

Overview
NPY NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Hormone
Chromosomal Location of Human Ortholog: 7p15.1
Cellular Component: extracellular space; cell; extracellular region
Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; G-protein-coupled receptor binding; calcium channel regulator activity; receptor binding
Biological Process: blood circulation; behavior; adult feeding behavior; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; cell proliferation; neuropeptide signaling pathway; positive regulation of appetite; regulation of blood pressure; calcium ion transport; digestion; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development
Reference #:  P01303 (UniProtKB)
Alt. Names/Synonyms: C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; Neuropeptide Y; NPY; PYY4
Gene Symbols: NPY
Molecular weight: 10,851 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NPY

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 Y48-p PAEDMARyysALRHy
0 35 Y49-p AEDMARyysALRHyI
0 1 S50-p EDMARyysALRHyIN
0 18 Y55-p yysALRHyINLITRQ
0 1 S75-p SSPETLIsDLLMREs
0 5 S82-p sDLLMREstENVPRT
0 3 T83-p DLLMREstENVPRTR
  mouse

 
Y48 PAEDMARYYSALRHY
Y49 AEDMARYYSALRHYI
S50 EDMARYYSALRHYIN
Y55 YYSALRHYINLITRQ
S75 SSPETLISDLLMKEs
S82-p SDLLMKEstENAPRT
T83-p DLLMKEstENAPRTR
  rat

 
Y49 PAEDMARYYSALRHY
Y50 AEDMARYYSALRHYI
S51 EDMARYYSALRHYIN
Y56 YYSALRHYINLITRQ
- under review  
S83-p SDLLMREsTENAPRT
T84 DLLMREsTENAPRTR
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