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MBD3 (human)

Overview MBD3 methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target. Note: This description may include information from UniProtKB. Protein type: Gene silencing; Transcription, coactivator/corepressor Cellular Component: heterochromatin; cytoplasm; NuRD complex Molecular Function: protein binding; DNA binding; chromatin binding Biological Process: tissue development; methylation-dependent chromatin silencing; transcription, DNA-dependent; in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; histone acetylation Reference #:  O95983 (UniProtKB) Alt. Names/Synonyms: MBD3; methyl-CpG binding domain protein 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3 Gene Symbols: MBD3 Molecular weight: 32,844 Da Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MBD3

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		K4	____MERKRWECPAL
1	1		S24-p	REEVPRRsGLSAGHR
0	1		Y35-p	AGHRDVFyysPsGKK
0	1		Y36-p	GHRDVFyysPsGKKF
0	7		S37-p	HRDVFyysPsGKKFR
0	2		S39-p	DVFyysPsGKKFRSK
0	13		S56-p	LARYLGGsMDLStFD
0	1		T61-p	GGsMDLStFDFRtGK
0	1		T66-p	LStFDFRtGKMLMSK
0	1		S77-p	LMSKMNKsRQRVRyD
0	2		Y83-p	KsRQRVRyDssNQVK
1	141		S85-p	RQRVRyDssNQVKGK
0	170		S86-p	QRVRyDssNQVKGKP
0	1		K141-a	PRQLFWEkKLsGLNA
0	1		K141-u	PRQLFWEkKLsGLNA
0	4		S144-p	LFWEkKLsGLNAFDI

	MBD3 iso2
K4-a	____MERksPsGKKF
-	gap
-	gap
-	gap
S5-p	___MERksPsGKKFR
S7-p	_MERksPsGKKFRSK
S24	LARYLGGSMDLSTFD
T29	GGSMDLSTFDFRTGK
T34	LSTFDFRTGKMLMSK
S45	LMSKMNKSRQRVRYD
Y51	KSRQRVRYDSSNQVK
S53	RQRVRYDSSNQVKGK
S54	QRVRYDSSNQVKGKP
K109	PRQLFWEKKLSGLNA
K109	PRQLFWEKKLSGLNA
S112	LFWEKKLSGLNAFDI

	mouse
K4	____MERKRWECPAL
S24-p	REEVPRRsGLSAGHR
Y35	AGHRDVFYYsPSGKK
Y36	GHRDVFYYsPSGKKF
S37-p	HRDVFYYsPSGKKFR
S39	DVFYYsPSGKKFRSK
S56-p	LARYLGGsMDLSTFD
T61	GGsMDLSTFDFRTGK
T66	LSTFDFRTGKMLMNK
S77	LMNKMNKSRQRVRYD
Y83	KSRQRVRYDssNQVK
S85-p	RQRVRYDssNQVKGK
S86-p	QRVRYDssNQVKGKP
K141	PRQLFWEKKLSGLSA
K141	PRQLFWEKKLSGLSA
S144	LFWEKKLSGLSAFDI

	rat
K4	____MERKRWECPAL
S24	REEVPRRSGLSAGHR
Y35	AGHRDVFYYSPSGKK
Y36	GHRDVFYYSPSGKKF
S37	HRDVFYYSPSGKKFR
S39	DVFYYSPSGKKFRSK
S56	LARYLGGSMDLSTFD
T61	GGSMDLSTFDFRTGK
T66	LSTFDFRTGKMLMNK
S77	LMNKMNKSRQRVRyD
Y83-p	KSRQRVRyDSSNQVK
S85	RQRVRyDSSNQVKGK
S86	QRVRyDSSNQVKGKP
K141	PRQLFWEKKLSGLSA
K141	PRQLFWEKKLSGLSA
S144	LFWEKKLSGLSAFDI

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