Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
MBD3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MBD3 methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target. Note: This description may include information from UniProtKB.
Protein type: Gene silencing; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: heterochromatin; protein complex; nuclear chromatin; cytoplasm; NuRD complex
Molecular Function: protein binding; nucleosomal DNA binding; methyl-CpG binding; DNA binding
Biological Process: tissue development; transcription, DNA-dependent; methylation-dependent chromatin silencing; in utero embryonic development; ATP-dependent chromatin remodeling; histone acetylation; negative regulation of transcription from RNA polymerase II promoter
Reference #:  O95983 (UniProtKB)
Alt. Names/Synonyms: MBD3; methyl-CpG binding domain protein 3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Gene Symbols: MBD3
Molecular weight: 32,844 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MBD3

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K4 ____MERKRWECPAL
1 1 S24-p REEVPRRsGLSAGHR
0 1 Y35-p AGHRDVFyysPsGKK
0 1 Y36-p GHRDVFyysPsGKKF
0 9 S37-p HRDVFyysPsGKKFR
0 3 S39-p DVFyysPsGKKFRSK
0 17 S56-p LARYLGGsMDLStFD
0 1 T61-p GGsMDLStFDFRtGK
0 1 T66-p LStFDFRtGKMLMSK
0 1 S77-p LMSKMNKsRQRVRyD
0 1 Y83-p KsRQRVRyDssNQVK
1 156 S85-p RQRVRyDssNQVKGK
0 175 S86-p QRVRyDssNQVKGKP
0 1 T97-p KGKPDLNtALPVRQT
0 1 K109-ac RQTASIFkQPVTKIT
0 1 K141-ac PRQLFWEkKLsGLNA
0 1 K141-ub PRQLFWEkKLsGLNA
0 7 S144-p LFWEkKLsGLNAFDI
  MBD3 iso2  
K4-ac ____MERksPsGKKF
- gap
- gap
- gap
S5-p ___MERksPsGKKFR
S7-p _MERksPsGKKFRSK
S24 LARYLGGSMDLSTFD
T29 GGSMDLSTFDFRTGK
T34 LSTFDFRTGKMLMSK
S45 LMSKMNKSRQRVRYD
Y51 KSRQRVRYDSSNQVK
S53 RQRVRYDSSNQVKGK
S54 QRVRYDSSNQVKGKP
T65 KGKPDLNTALPVRQT
K77 RQTASIFKQPVTKIT
K109 PRQLFWEKKLSGLNA
K109 PRQLFWEKKLSGLNA
S112 LFWEKKLSGLNAFDI
  mouse

 
K4 ____MERKRWECPAL
S24-p REEVPRRsGLSAGHR
Y35 AGHRDVFYYsPSGKK
Y36 GHRDVFYYsPSGKKF
S37-p HRDVFYYsPSGKKFR
S39 DVFYYsPSGKKFRSK
S56-p LARYLGGsMDLSTFD
T61 GGsMDLSTFDFRTGK
T66 LSTFDFRTGKMLMNK
S77 LMNKMNKSRQRVRYD
Y83 KSRQRVRYDssNQVK
S85-p RQRVRYDssNQVKGK
S86-p QRVRYDssNQVKGKP
T97 KGKPDLNTALPVRQT
K109 RQTASIFKQPVTKIT
K141 PRQLFWEKKLSGLSA
K141 PRQLFWEKKLSGLSA
S144 LFWEKKLSGLSAFDI
  rat

 
K4 ____MERKRWECPAL
S24 REEVPRRSGLSAGHR
Y35 AGHRDVFYYSPSGKK
Y36 GHRDVFYYSPSGKKF
S37 HRDVFYYSPSGKKFR
S39 DVFYYSPSGKKFRSK
S56-p LARYLGGsMDLSTFD
T61 GGsMDLSTFDFRTGK
T66 LSTFDFRTGKMLMNK
S77 LMNKMNKSRQRVRYD
Y83 KSRQRVRYDssNQVK
S85-p RQRVRYDssNQVKGK
S86-p QRVRYDssNQVKGKP
T97 KGKPDLNTALPVRQT
K109-ac RQTASIFkQPVTKIT
K141-ac PRQLFWEkKLSGLSA
K141 PRQLFWEKKLSGLSA
S144 LFWEkKLSGLSAFDI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.