Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ROS (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ROS a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; TK group; Sev family
Cellular Component: membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding
Biological Process: cell proliferation; peptidyl-tyrosine phosphorylation; spermatogenesis; cell growth; columnar/cuboidal epithelial cell development; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of TOR signaling pathway
Reference #:  P08922 (UniProtKB)
Alt. Names/Synonyms: c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; proto-oncogene c-ros-1 protein; Proto-oncogene tyrosine-protein kinase ROS; ROS; ROS1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Symbols: ROS1
Molecular weight: 263,915 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ROS

Protein Structure Not Found.


STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: Y2274‑p, Y2334‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y135-p KYIIQWKyAQLLGSW
0 2 Y144-p QLLGSWTyTKTVSRP
0 2 S1185-p FSAERVIsAVCYtAD
0 2 T1190-p VIsAVCYtADNEMGY
0 1 Y1535-p IQIAVKNyYSDPLEH
0 2 K1749-a LPESFKTkAGVPNKP
0 9 Y1923-p VGLANACyAIHTLPt
0 2 T1930-p yAIHTLPtQEEIENL
0 3 Y2069-p DISKGCVyLERMHFI
1 17 Y2110-p FGLARDIyKNDyyRK
1 16 Y2114-p RDIyKNDyyRKRGEG
1 15 Y2115-p DIyKNDyyRKRGEGL
0 2 Y2173-p SNLDVLNyVQTGGRL
0 3 Y2227-p NFFLNSIyKSRDEAN
1 11 Y2274-p KNREGLNyMVLATEC
0 8 Y2323-p CQEKQVAyCPSGKPE
1 20 Y2334-p GKPEGLNyACLtHSG
0 2 T2338-p GLNyACLtHSGyGDG
0 3 Y2342-p ACLtHSGyGDGsD__
0 2 S2346-p HSGyGDGsD______
3078 : Phospho-Ros (Tyr2274) Antibody
  mouse

 
Y145 KYIIQWKYAQLPGSW
F154 QLPGSWTFTETVSKL
S1181 FSLEGDVSTVGYTTD
T1186 DVSTVGYTTDDEMGY
Y1528 IQIAVKNYYSEPLEH
K1742 IPESFKTKAGVPSKP
Y1916 VGLANACYAVHTVPT
T1923 YAVHTVPTQEEIENL
Y2062 DISKGCVYLEQMHFI
Y2103-p FGLAREIyKNDyyRK
Y2107-p REIyKNDyyRKRGEG
Y2108-p EIyKNDyyRKRGEGL
Y2166 SNLDVLNYVQAGGRL
S2220 NVFLNNVSHCGEAAP
Y2267 KNQEGLNYMVLATKC
Y2316 CQEPQVAYGSPGLSE
Y2327 GLSEGLNYACLAHSE
A2331 GLNYACLAHSEHGDV
H2335 ACLAHSEHGDVSE__
S2339 HSEHGDVSE______
3078 : Phospho-Ros (Tyr2274) Antibody
  rat

 
Y144 KYIIQWKYAQLPGSW
Y153 QLPGSWAYTETVSKL
S1180 FSLEGAVSTVGYTAD
T1185 AVSTVGYTADDEMGY
Y1527 IQIAVKNYYSDPLEH
K1741 IPESFKTKAGVPSKP
Y1915 VGLANACYAVHTLPT
T1922 YAVHTLPTQEEIESL
Y2061 DISKGCVYLEQMHFI
Y2102 FGLAREIYKHDYYRK
Y2106 REIYKHDYYRKRGEG
Y2107 EIYKHDYYRKRGEGL
Y2165 SNLDVLNYVQAGGRL
S2219 NVSLNNVSHCGQAAP
Y2266 RNQEGLNYMVLATKC
Y2314 CQQPQVAYGSPGHSE
Y2325 GHSEGLNYACLAHSG
A2329 GLNYACLAHSGHGDV
H2333 ACLAHSGHGDVSE__
S2337 HSGHGDVSE______
3078 : Phospho-Ros (Tyr2274) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.