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ROS (human)

Overview ROS a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Sev family Cellular Component: membrane; plasma membrane; integral to membrane Molecular Function: protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding Biological Process: cell proliferation; spermatogenesis; columnar/cuboidal epithelial cell development; cell differentiation; cell growth; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of TOR signaling pathway Reference #:  P08922 (UniProtKB) Alt. Names/Synonyms: c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; proto-oncogene c-ros-1 protein; Proto-oncogene tyrosine-protein kinase ROS; ROS; ROS1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1 Gene Symbols: ROS1 Molecular weight: 263,915 Da Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ROS

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	Sites Implicated In
molecular association, regulation: Y2274‑p, Y2334‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y135-p	KYIIQWKyAQLLGSW
0	1		T143-p	AQLLGSWtytKTVSR
0	2		Y144-p	QLLGSWtytKTVSRP
0	1		T145-p	LLGSWtytKTVSRPS
0	1		T188-p	PPSPSYRtHPHGVPE
0	1		T196-p	HPHGVPEtAPLIRNI
0	1		Y800-p	VVDSVGGyLyWTTLy
0	1		Y802-p	DSVGGyLyWTTLySV
0	1		Y807-p	yLyWTTLySVESTRL
0	1		S818-p	STRLNGEsSLVLQTQ
0	1		T859	SQCIHLYTAVLRGQS
0	1		S866	TAVLRGQSTGDTTIT
0	1		T871	GQSTGDTTITEFAAW
0	1		T873	STGDTTITEFAAWST
0	1		S1092	FYNISNQSITNKTCE
0	1		T1094	NISNQSITNKTCEDW
0	1		T1097	NQSITNKTCEDWIAV
0	1		C1098	QSITNKTCEDWIAVN
0	2		S1185-p	FSAERVIsAVCYtAD
0	2		T1190-p	VIsAVCYtADNEMGY
0	1		K1259-a	FDVDLEHkVKYPREV
0	1		S1273-p	VKIHNRNstIISFSV
0	1		T1274-p	KIHNRNstIISFSVY
0	1		T1375-p	CQCWRVItVPAMLAG
0	1		K1504-a	RKNSSDLkYRILEFQ
0	1		Y1535-p	IQIAVKNyYSDPLEH
0	2		K1749-a	LPESFKTkAGVPNKP
0	9		Y1923-p	VGLANACyAIHtLPt
0	1		T1927-p	NACyAIHtLPtQEEI
0	2		T1930-p	yAIHtLPtQEEIENL
0	1		K1944-a	LPAFPREkLTLRLLL
0	1		S2002-p	LKEAHLMsKFNHPNI
0	1		Y2023-p	CLLNEPQyIILELME
0	3		Y2069-p	DISKGCVyLERMHFI
1	17		Y2110-p	FGLARDIyKNDyyRK
1	16		Y2114-p	RDIyKNDyyRKRGEG
1	15		Y2115-p	DIyKNDyyRKRGEGL
0	2		Y2173-p	SNLDVLNyVQTGGRL
0	3		Y2227-p	NFFLNSIyKSRDEAN
1	11		Y2274-p	KNREGLNyMVLATEC
0	8		Y2323-p	CQEKQVAyCPsGKPE
0	1		S2326-p	KQVAyCPsGKPEGLN
1	20		Y2334-p	GKPEGLNyACLtHSG
0	2		T2338-p	GLNyACLtHSGyGDG
0	3		Y2342-p	ACLtHSGyGDGsD__
0	2		S2346-p	HSGyGDGsD______

	mouse
Y145	KYIIQWKYAQLPGSW
T153	AQLPGSWTFTETVSK
F154	QLPGSWTFTETVSKL
T155	LPGSWTFTETVSKLS
T198	PPSPSYRTHPYGVPE
T206	HPYGVPETAPLILNM
Y796	AVDSVGGYLYWTTLY
Y798	DSVGGYLYWTTLYSV
Y803	YLYWTTLYSVESTRL
S814	STRLNGESSLVLQAQ
T855-p	NQCIHLYtAVLRGWs
S862-p	tAVLRGWsGGDAtIt
T867-p	GWsGGDAtItEFAAW
T869-p	sGGDAtItEFAAWST
S1088-p	FYHISKQsGtNRstE
T1090-p	HISKQsGtNRstEDW
S1093-p	KQsGtNRstEDWMSA
T1094-p	QsGtNRstEDWMSAS
S1181	FSLEGDVSTVGYTTD
T1186	DVSTVGYTTDDEMGY
K1255	FNVDLEHKVKSPREV
T1269	VKTCKAHTTIISFSI
T1270	KTCKAHTTIISFSIY
M1370	CQCWKVIMVPTIPGK
R1497	RANSSDRRHKMLESQ
Y1528	IQIAVKNYYSEPLEH
K1742	IPESFKTKAGVPSKP
Y1916	VGLANACYAVHTVPT
T1920	NACYAVHTVPTQEEI
T1923	YAVHTVPTQEEIENL
K1937	LPAFPREKLSLRLLL
S1995	LKEAHLMSKFNHPNI
Y2016	CLLGEPQYIILELME
Y2062	DISKGCVYLEQMHFI
Y2103-p	FGLAREIyKNDyyRK
Y2107-p	REIyKNDyyRKRGEG
Y2108-p	EIyKNDyyRKRGEGL
Y2166	SNLDVLNYVQAGGRL
S2220	NVFLNNVSHCGEAAP
Y2267	KNQEGLNYMVLATKC
Y2316	CQEPQVAYGSPGLSE
P2319	PQVAYGSPGLSEGLN
Y2327	GLSEGLNYACLAHSE
A2331	GLNYACLAHSEHGDV
H2335	ACLAHSEHGDVSE__
S2339	HSEHGDVSE______

	rat
Y144	KYIIQWKYAQLPGSW
A152	AQLPGSWAYTETVSK
Y153	QLPGSWAYTETVSKL
T154	LPGSWAYTETVSKLS
T197	PPSPSYRTHPYGVPE
T205	HPYGVPETAPFITNI
Y795	AVDPVGGYLYWTTLY
Y797	DPVGGYLYWTTLYSV
Y802	YLYWTTLYSVESTRL
S813	STRLNGESSLVLQAQ
T854	NQCIHLYTAVLRGWS
S861	TAVLRGWSGADATIT
T866	GWSGADATITEFAAW
T868	SGADATITEFAAWST
S1087	FYHISKQSGTNKSTE
T1089	HISKQSGTNKSTEDW
S1092	KQSGTNKSTEDWVSV
T1093	QSGTNKSTEDWVSVS
S1180	FSLEGAVSTVGYTAD
T1185	AVSTVGYTADDEMGY
K1254	FDVDLEHKVKSPREV
T1268	VKICKSHTAIISFSM
A1269	KICKSHTAIISFSMY
M1369	CQCWKVIMVPATPGK
K1496	RANSSDRKHNMLESQ
Y1527	IQIAVKNYYSDPLEH
K1741	IPESFKTKAGVPSKP
Y1915	VGLANACYAVHTLPT
T1919	NACYAVHTLPTQEEI
T1922	YAVHTLPTQEEIESL
K1936	LPAFPREKLSLRLLL
S1994	LKEAHLMSKFNHPNI
Y2015	CLLSEPQYIILELME
Y2061	DISKGCVYLEQMHFI
Y2102	FGLAREIYKHDYYRK
Y2106	REIYKHDYYRKRGEG
Y2107	EIYKHDYYRKRGEGL
Y2165	SNLDVLNYVQAGGRL
S2219	NVSLNNVSHCGQAAP
Y2266	RNQEGLNYMVLATKC
Y2314	CQQPQVAYGSPGHSE
P2317	PQVAYGSPGHSEGLN
Y2325	GHSEGLNYACLAHSG
A2329	GLNYACLAHSGHGDV
H2333	ACLAHSGHGDVSE__
S2337	HSGHGDVSE______

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