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Protein Page:
ROS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ROS a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Sev family
Cellular Component: membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding
Biological Process: cell proliferation; peptidyl-tyrosine phosphorylation; spermatogenesis; columnar/cuboidal epithelial cell development; cell differentiation; cell growth; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of TOR signaling pathway
Reference #:  P08922 (UniProtKB)
Alt. Names/Synonyms: c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; proto-oncogene c-ros-1 protein; Proto-oncogene tyrosine-protein kinase ROS; ROS; ROS1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Symbols: ROS1
Molecular weight: 263,915 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ROS

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y2274‑p, Y2334‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y135-p KYIIQWKyAQLLGSW
0 1 T143-p AQLLGSWtytKTVSR
0 1 Y144-p QLLGSWtytKTVSRP
0 1 T145-p LLGSWtytKTVSRPS
0 1 T188-p PPSPSYRtHPHGVPE
0 1 T196-p HPHGVPEtAPLIRNI
0 1 Y800-p VVDSVGGyLyWTTLy
0 1 Y802-p DSVGGyLyWTTLySV
0 1 Y807-p yLyWTTLySVESTRL
0 1 S818-p STRLNGEsSLVLQTQ
0 1 T859 SQCIHLYTAVLRGQS
0 1 S866 TAVLRGQSTGDTTIT
0 1 T871 GQSTGDTTITEFAAW
0 1 T873 STGDTTITEFAAWST
0 1 S1092 FYNISNQSITNKTCE
0 1 T1094 NISNQSITNKTCEDW
0 1 T1097 NQSITNKTCEDWIAV
0 1 C1098 QSITNKTCEDWIAVN
0 2 S1185-p FSAERVIsAVCYtAD
0 2 T1190-p VIsAVCYtADNEMGY
0 1 K1259-ac FDVDLEHkVKYPREV
0 1 S1273-p VKIHNRNstIISFSV
0 1 T1274-p KIHNRNstIISFSVY
0 1 T1375-p CQCWRVItVPAMLAG
0 1 K1504-ac RKNSSDLkYRILEFQ
0 1 Y1535-p IQIAVKNyYSDPLEH
0 2 K1749-ac LPESFKTkAGVPNKP
0 9 Y1923-p VGLANACyAIHtLPt
0 1 T1927-p NACyAIHtLPtQEEI
0 2 T1930-p yAIHtLPtQEEIENL
0 1 K1944-ac LPAFPREkLTLRLLL
0 1 S2002-p LKEAHLMsKFNHPNI
0 1 Y2023-p CLLNEPQyIILELME
0 3 Y2069-p DISKGCVyLERMHFI
1 17 Y2110-p FGLARDIyKNDyyRK
1 16 Y2114-p RDIyKNDyyRKRGEG
1 15 Y2115-p DIyKNDyyRKRGEGL
0 2 Y2173-p SNLDVLNyVQTGGRL
0 3 Y2227-p NFFLNSIyKSRDEAN
1 11 Y2274-p KNREGLNyMVLATEC
0 8 Y2323-p CQEKQVAyCPsGKPE
0 1 S2326-p KQVAyCPsGKPEGLN
1 20 Y2334-p GKPEGLNyACLtHSG
0 2 T2338-p GLNyACLtHSGyGDG
0 3 Y2342-p ACLtHSGyGDGsD__
0 2 S2346-p HSGyGDGsD______
3078 : Phospho-Ros (Tyr2274) Antibody
  mouse

 
Y145 KYIIQWKYAQLPGSW
T153 AQLPGSWTFTETVSK
F154 QLPGSWTFTETVSKL
T155 LPGSWTFTETVSKLS
T198 PPSPSYRTHPYGVPE
T206 HPYGVPETAPLILNM
Y796 AVDSVGGYLYWTTLY
Y798 DSVGGYLYWTTLYSV
Y803 YLYWTTLYSVESTRL
S814 STRLNGESSLVLQAQ
T855-p NQCIHLYtAVLRGWs
S862-p tAVLRGWsGGDAtIt
T867-p GWsGGDAtItEFAAW
T869-p sGGDAtItEFAAWST
S1088-p FYHISKQsGtNRstE
T1090-p HISKQsGtNRstEDW
S1093-p KQsGtNRstEDWMSA
T1094-p QsGtNRstEDWMSAS
S1181 FSLEGDVSTVGYTTD
T1186 DVSTVGYTTDDEMGY
K1255 FNVDLEHKVKSPREV
T1269 VKTCKAHTTIISFSI
T1270 KTCKAHTTIISFSIY
M1370 CQCWKVIMVPTIPGK
R1497 RANSSDRRHKMLESQ
Y1528 IQIAVKNYYSEPLEH
K1742 IPESFKTKAGVPSKP
Y1916 VGLANACYAVHTVPT
T1920 NACYAVHTVPTQEEI
T1923 YAVHTVPTQEEIENL
K1937 LPAFPREKLSLRLLL
S1995 LKEAHLMSKFNHPNI
Y2016 CLLGEPQYIILELME
Y2062 DISKGCVYLEQMHFI
Y2103-p FGLAREIyKNDyyRK
Y2107-p REIyKNDyyRKRGEG
Y2108-p EIyKNDyyRKRGEGL
Y2166 SNLDVLNYVQAGGRL
S2220 NVFLNNVSHCGEAAP
Y2267 KNQEGLNYMVLATKC
Y2316 CQEPQVAYGSPGLSE
P2319 PQVAYGSPGLSEGLN
Y2327 GLSEGLNYACLAHSE
A2331 GLNYACLAHSEHGDV
H2335 ACLAHSEHGDVSE__
S2339 HSEHGDVSE______
3078 : Phospho-Ros (Tyr2274) Antibody
  rat

 
Y144 KYIIQWKYAQLPGSW
A152 AQLPGSWAYTETVSK
Y153 QLPGSWAYTETVSKL
T154 LPGSWAYTETVSKLS
T197 PPSPSYRTHPYGVPE
T205 HPYGVPETAPFITNI
Y795 AVDPVGGYLYWTTLY
Y797 DPVGGYLYWTTLYSV
Y802 YLYWTTLYSVESTRL
S813 STRLNGESSLVLQAQ
T854 NQCIHLYTAVLRGWS
S861 TAVLRGWSGADATIT
T866 GWSGADATITEFAAW
T868 SGADATITEFAAWST
S1087 FYHISKQSGTNKSTE
T1089 HISKQSGTNKSTEDW
S1092 KQSGTNKSTEDWVSV
T1093 QSGTNKSTEDWVSVS
S1180 FSLEGAVSTVGYTAD
T1185 AVSTVGYTADDEMGY
K1254 FDVDLEHKVKSPREV
T1268 VKICKSHTAIISFSM
A1269 KICKSHTAIISFSMY
M1369 CQCWKVIMVPATPGK
K1496 RANSSDRKHNMLESQ
Y1527 IQIAVKNYYSDPLEH
K1741 IPESFKTKAGVPSKP
Y1915 VGLANACYAVHTLPT
T1919 NACYAVHTLPTQEEI
T1922 YAVHTLPTQEEIESL
K1936 LPAFPREKLSLRLLL
S1994 LKEAHLMSKFNHPNI
Y2015 CLLSEPQYIILELME
Y2061 DISKGCVYLEQMHFI
Y2102 FGLAREIYKHDYYRK
Y2106 REIYKHDYYRKRGEG
Y2107 EIYKHDYYRKRGEGL
Y2165 SNLDVLNYVQAGGRL
S2219 NVSLNNVSHCGQAAP
Y2266 RNQEGLNYMVLATKC
Y2314 CQQPQVAYGSPGHSE
P2317 PQVAYGSPGHSEGLN
Y2325 GHSEGLNYACLAHSG
A2329 GLNYACLAHSGHGDV
H2333 ACLAHSGHGDVSE__
S2337 HSGHGDVSE______
3078 : Phospho-Ros (Tyr2274) Antibody
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