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ROR1 (human)

Overview ROR1 Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.1; Membrane protein, integral; Kinase, protein; Protein kinase, TK; EC 2.7.1.112; Protein kinase, tyrosine (receptor); TK group; Ror family Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane Molecular Function: Wnt-protein binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  Q01973 (UniProtKB) Alt. Names/Synonyms: dJ537F10.1; MGC99659; neurotrophic tyrosine kinase receptor-related 1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; receptor tyrosine kinase-like orphan receptor 1; ROR1; Tyrosine-protein kinase transmembrane receptor ROR1 Gene Symbols: ROR1 Molecular weight: 104,283 Da Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ROR1

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME 2.7.1.112 2.7.10.1  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T9-p	HRPRRRGtRPPLLAL
0	1		Y160-p	PPTASPGysDEYEED
0	1		S161-p	PTASPGysDEYEEDG
0	2		Y173-p	EDGFCQPyRGIACAR
0	1		S393	CDIPACDSKDSKEKN
0	1		Y459-p	EMSMLNAyKPKSkAK
0	2		K464-u	NAyKPKSkAKELPLS
0	1		S652	YYRVQSKSLLPIRWM
0	5		Y786-p	SNLSNPRyPNyMFPS
0	2		Y789-p	SNPRyPNyMFPSQGI
0	10		Y828-p	GYPIPPGyAAFPAAH
0	9		Y836-p	AAFPAAHyQPTGPPR

	ROR1 iso3
T9	HRPRRRGTRPPLLAL
Y160	PPTASPGYSDEYEED
S161	PTASPGYSDEYEEDG
Y173	EDGFCQPYRGIACAR
K393-a	CDIPACGk_______
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	mouse
T9	HRPRRRGTRPPPLAL
S160	PPTASPGSSDEYEED
S161	PTASPGSSDEYEEDG
Y173	EDGFCQPYRGIACAR
S393	CDIPACDSKDSKEKN
Y459	EMSMLNAYKPKSKAK
K464	NAYKPKSKAKELPLS
S652-p	YYRVQSKsSLPIRWM
F786	SNLSNPRFPNYMFPS
Y789	SNPRFPNYMFPSQGI
Y828	GYPIPPGYAAFPAAH
Y836	AAFPAAHYQPAGPPR

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