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RRAGB (human)

Overview RRAGB Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosome; cytoplasm; nucleus Molecular Function: protein binding; GTP binding Biological Process: signal transduction; positive regulation of TOR signaling pathway Reference #:  Q5VZM2 (UniProtKB) Alt. Names/Synonyms: bA465E19.1; GTP-binding protein ragB; Rag B; RagB; Ras-related GTP binding B; Ras-related GTP-binding protein B; RRAGB Gene Symbols: RRAGB Molecular weight: 43,250 Da Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RRAGB

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K281	VISHYQCKEQRDAHR
0	1		K297-a	EKISNIIkQFkLSCS
0	1		K300-a	SNIIkQFkLSCSkLA
0	1		K305-a	QFkLSCSkLAASFQS
0	2		K305-u	QFkLSCSkLAASFQS

	mouse
K281-u	VISHYQCkEQRDAHR
K297	EKISNIIKQFKLSCS
K300	SNIIKQFKLSCSkLA
K305	QFKLSCSKLAASFQS
K305-u	QFKLSCSkLAASFQS

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