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GPVI (human)

Overview GPVI Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: collagen binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: platelet activation; blood coagulation; leukocyte migration; enzyme linked receptor protein signaling pathway Reference #:  Q9HCN6 (UniProtKB) Alt. Names/Synonyms: Glycoprotein 6; glycoprotein VI (platelet); GP6; GPIV; GPVI; MGC138168; platelet collagen receptor; Platelet glycoprotein VI Gene Symbols: GP6 Molecular weight: 36,866 Da Basal Isoelectric point: 9.35  Predict pI for various phosphorylation states

Select Structure to View Below GPVI 2GI7 - A/B=21-203 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y67-p	EKLSSSRyQDQAVLF

	mouse
Y68	EKLKPEKYEDQDFLF

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