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INPP4B (human)

Overview INPP4B Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. Note: This description may include information from UniProtKB. Protein type: Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.66; Motility/polarity/chemotaxis Cellular Component: cytosol Molecular Function: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction Reference #:  O15327 (UniProtKB) Alt. Names/Synonyms: 4-phosphatase II; inositol polyphosphate 4-phosphatase II; Inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase, type II, 105kDa; INP4B; INPP4B; MGC132014; Type II inositol-3,4-bisphosphate 4-phosphatase Gene Symbols: INPP4B Molecular weight: 104,738 Da Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below INPP4B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y115-p	TKIKLTVyDVKDKsH
0	1		S121-p	VyDVKDKsHDTVRTS
0	1		Y147-p	VGRSFLGyASFKVGE
0	1		S217	CECTAPESVSGKDNL
0	1		S270-p	HIPKELIsLHIKEDL
0	1		K448-a	DSLKNSLkMLSEKTE
0	2		S468-p	FKDQLVRsALLALYT
0	1		Y474	RsALLALYTARPGGI
0	1		S487	GILKKPPSPKSSTEE
0	7		S509-p	PVMRGQDsIPHHSDY
0	3		S514	QDsIPHHSDYDEEEW
0	1		G547	DKLIERDGGSEGSGG
0	1		K891	CRIENVLKNIKCRKy
0	1		Y898-p	KNIKCRKyAFNMLQL

	mouse
Y115	TRIKLTVYDVKDKSH
S121	VYDVKDKSHDTRSFL
C130	DTRSFLGCASFKVGE
S200-p	YESTAPEsLSGKENL
S253	HIPKELISLHIKEDL
K431	DSLKSSLKLLSEKTE
S451	FKDQLVRSALLALYT
Y457	RSALLALYTARPGGI
S470-p	GILKKPPsPNVSTEE
S492-p	PQLRRQDsIPHHsDY
S497-p	QDsIPHHsDYDEEEW
S530-p	DKLIERDsHNEEGAG
K889-u	TGCLTDNkPTSRHFY
-	gap

	rat
Y115	TRIKLTVYDVKDKPH
P121	VYDVKDKPHDTIRTS
C147	VARSFLGCASFKVGE
S217	YDSTAPESLSGKENL
S270	HIPKELISLHIKEDL
K448	DSLRSSLKLLSEKTE
S468	FKDQLVRSALLALyT
Y474-p	RSALLALyTARPGGI
S487	GILRKPPSPKVSTEE
S510	QQLRRQDSIPHHSDY
S515	QDSIPHHSDYDEEEW
S548	DKLIERDSRNDKSTG
K895	CRIENVLKNIKCRRY
Y902	KNIKCRRYAFNMLQL

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