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Protein Page:
INPP4B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
INPP4B Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. Note: This description may include information from UniProtKB.
Protein type: Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.66; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; cytosol
Molecular Function: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; lipid binding
Biological Process: cellular calcium ion homeostasis; negative regulation of osteoclast differentiation; inositol phosphate metabolic process; dephosphorylation; phospholipid metabolic process; regulation of nucleocytoplasmic transport; phosphatidylinositol biosynthetic process; regulation of bone remodeling; regulation of protein kinase B signaling cascade; signal transduction
Reference #:  O15327 (UniProtKB)
Alt. Names/Synonyms: 4-phosphatase II; inositol polyphosphate 4-phosphatase II; Inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase, type II, 105kDa; INP4B; INPP4B; MGC132014; Type II inositol-3,4-bisphosphate 4-phosphatase
Gene Symbols: INPP4B
Molecular weight: 104,738 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

INPP4B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T61-p VRDRKLNtLVQIsVI
0 1 S66-p LNtLVQIsVIHPVEQ
0 1 S74-p VIHPVEQsLtRYSST
0 1 T76-p HPVEQsLtRYSSTEI
0 4 Y115-p TKIKLTVyDVKDKsH
0 1 S121-p VyDVKDKsHDTVRTS
0 1 Y147-p VGRSFLGyASFKVGE
0 1 S217 CECTAPESVSGKDNL
0 1 S270-p HIPKELIsLHIKEDL
0 1 K448-ac DSLKNSLkMLSEKTE
0 2 S468-p FKDQLVRsALLALYT
0 1 S487 GILKKPPSPKSSTEE
0 7 S509 PVMRGQDSIPHHSDY
0 3 S514 QDSIPHHSDYDEEEW
0 1 G547 DKLIERDGGSEGSGG
0 1 K891 CRIENVLKNIKCRKy
0 1 Y898-p KNIKCRKyAFNMLQL
  mouse

 
T61 VSDRKLNTVVQISVI
S66 LNTVVQISVIHPVEQ
T74 VIHPVEQTLTRYSST
T76 HPVEQTLTRYSSTEI
Y115 TRIKLTVYDVKDKSH
S121 VYDVKDKSHDTRSFL
C130 DTRSFLGCASFKVGE
S200-p YESTAPEsLSGKENL
S253 HIPKELISLHIKEDL
K431 DSLKSSLKLLSEKTE
S451 FKDQLVRSALLALYT
S470-p GILKKPPsPNVSTEE
S492-p PQLRRQDsIPHHsDY
S497-p QDsIPHHsDYDEEEW
S530-p DKLIERDsHNEEGAG
K889-ub TGCLTDNkPTSRHFY
- gap
  rat

 
T61 VSDRKLNTVVQVSVI
S66 LNTVVQVSVIHPVEQ
T74 VIHPVEQTLTRYSST
T76 HPVEQTLTRYSSTEI
Y115 TRIKLTVYDVKDKPH
P121 VYDVKDKPHDTIRTS
C147 VARSFLGCASFKVGE
S217 YDSTAPESLSGKENL
S270 HIPKELISLHIKEDL
K448 DSLRSSLKLLSEKTE
S468 FKDQLVRSALLALYT
S487 GILRKPPSPKVSTEE
S510 QQLRRQDSIPHHSDY
S515 QDSIPHHSDYDEEEW
S548 DKLIERDSRNDKSTG
K895 CRIENVLKNIKCRRY
Y902 KNIKCRRYAFNMLQL
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