a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; EC 18.104.22.168; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; Met family
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: integral to plasma membrane; stress fiber
Molecular Function: macrophage colony stimulating factor receptor activity; protein binding; enzyme binding; ATP binding
Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; single fertilization; multicellular organismal development; response to virus; positive regulation of cell proliferation; innate immune response; defense response; signal transduction; cell motility; transmembrane receptor protein tyrosine kinase signaling pathway
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.