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Ron (human)

Overview Ron a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; TK group; Met family Cellular Component: integral to plasma membrane; stress fiber Molecular Function: macrophage colony stimulating factor receptor activity; protein binding; enzyme binding; ATP binding Biological Process: positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; multicellular organismal development; single fertilization; response to virus; positive regulation of cell proliferation; innate immune response; defense response; cell motility; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  Q04912 (UniProtKB) Alt. Names/Synonyms: c-met-related tyrosine kinase; CD136; CDw136; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R; p185-Ron; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; RON; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4 Gene Symbols: MST1R Molecular weight: 152,271 Da Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Ron 3PLS - A=1060-1357 (human) 4FWW - A=42-568 (human)

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	Sites Implicated In
cell growth, altered: Y1317‑p, Y1353‑p, Y1360‑p enzymatic activity, induced: Y1238‑p molecular association, regulation: S1394‑p phosphorylation: Y1353‑p, Y1360‑p protein conformation: Y1238‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S215-p	AASFSPRsVSIRRLk
0	1		K222-u	sVSIRRLkADAsGFA
0	1		S226-p	RRLkADAsGFAPGFV
0	1		S236-p	APGFVALsVLPKHLV
0	6		Y1017-p	ILYSGSDyRSGLALP
0	5		Y1101-p	GVVYHGEyIDQAQNR
1	0		Y1198	QVARSMEYLAEQKFV
1	144		Y1238-p	RDILDREyysVQQHR
1	97		Y1239-p	DILDREyysVQQHRH
0	4		S1240-p	ILDREyysVQQHRHA
1	0		Y1288	LTRGAPPYRHIDPFD
2	0		Y1317-p	EYCPDSLyQVMQQCW
3	0		Y1353-p	SALLGDHyVQLPATy
3	0		Y1360-p	yVQLPATyMNLGPST
2	23		S1394-p	VRRPRPLsEPPRPT_

	mouse
S216-p	AASFSPRsVSIRRLK
K223	sVSIRRLKSDTSGFQ
S227	RRLKSDTSGFQPGFP
S237	QPGFPSLSVLPKYLA
-	gap
Y1078	GVVYHGEYTDGAQNQ
Y1175-p	QVACGMEyLAEQKFV
Y1215-p	RGVLDKEyYSVRQHR
Y1216	GVLDKEyYSVRQHRH
S1217	VLDKEyYSVRQHRHA
Y1265-p	LTRGAPPyPHIDPFD
Y1294-p	EYCPDSLyHVMLRCW
Y1330-p	ASLLGDHyVQLTAAy
Y1337-p	yVQLTAAyVNVGPRA
S1372	TSKPRPLSEPPLPT_

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