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Protein Page:
SMYD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMYD2 Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Expression is repressed by CEBPA. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.43; EC 2.1.1.; Methyltransferase; EC 2.1.1.-; Methyltransferase, protein lysine
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein binding; p53 binding; metal ion binding; protein-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K36 specific)
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; histone H3-K36 methylation; negative regulation of transcription from RNA polymerase II promoter; regulation of DNA damage response, signal transduction by p53 class mediator
Reference #:  Q9NRG4 (UniProtKB)
Alt. Names/Synonyms: HSKM-B; KMT3C; Lysine N-methyltransferase 3C; MGC119305; SET and MYND domain containing 2; SET and MYND domain-containing protein 2; SMYD2; zinc finger, MYND domain containing 14; ZMYND14
Gene Symbols: SMYD2
Molecular weight: 49,688 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMYD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S14 GGLERFCSPGKGRGL
0 1 S35-p QVGDLLFsCPAYAYV
0 1 T44-p PAYAYVLtVNERGNH
0 1 K145-ub LDKLDNEkkDLIQSD
0 1 K146-ub DKLDNEkkDLIQSDI
1 0 Y240 GEEVFTSYIDLLYPT
0 1 S283-p KVEIRKLsDPPKAEA
0 1 D284 VEIRKLsDPPKAEAI
0 1 Y377-p YSKHYPLySLNVASM
  mouse

 
S14-p GGLERFCsAGKGRGL
S35 HVGDLLFSCPAYACV
T44 PAYACVLTVGERGHH
K145 LDKLDNEKKDLIQSD
K146 DKLDNEKKDLIQSDI
Y240-p GDEVFTSyIDLLYPT
S283 KVEVRKLSsPPQAEA
S284-p VEVRKLSsPPQAEAI
Y377 YSKHYPVYSLNVASM
  rat

 
S14 GGLERFCSAGKGRGL
S35 HVGDLLFSCPAYACV
T44 PAYACVLTVGERGHH
K145 LDKLDNEKKDLIQSD
K146 DKLDNEKKDLIQSDI
Y240 GDEVFTSYIDLLYPT
S283-p KVEIRKLsNPPQAEA
N284 VEIRKLsNPPQAEAI
Y377 YSKHYPVYSLNVASM
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