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Protein Page:
STRC (human)

Overview
STRC Essential to the formation of horizontal top connectors between outer hair cell stereocilia. Defects in STRC are the cause of deafness autosomal recessive type 16 (DFNB16). DFNB16 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in STRC are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the stereocilin family. Note: This description may include information from UniProtKB.
Cellular Component: stereocilium; cell surface; stereocilium bundle tip
Biological Process: auditory receptor cell stereocilium organization and biogenesis; detection of mechanical stimulus involved in sensory perception of sound
Reference #:  Q7RTU9 (UniProtKB)
Alt. Names/Synonyms: DFNB16; MGC156147; Stereocilin; STRC
Gene Symbols: STRC
Molecular weight: 192,967 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Select Structure to View Below

STRC

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T628-p HYLLRLLtFLLGPGA
0 1 S702 VNPSSGISKMELLAC
0 1 S1147-p LKLLQLDsLALLANR
  mouse

 
T668 HYLLRLLTFLLGPGT
S740-p LSLGSGMsKMELLSC
A1181 LKLLQLDAAALLANR
  rat

 
T668 HYLLRLLTFLLGPGA
S740 DSLGSGLSKMELLSC
T1183 LKLLQLDTAALLANR
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