|
FGG
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted, signal peptide; Secreted |
|
Cellular Component: extracellular space; fibrinogen complex; extracellular region; plasma membrane; cell cortex; external side of plasma membrane
|
|
Molecular Function: protein binding, bridging; eukaryotic cell surface binding; metal ion binding; receptor binding
|
|
Biological Process: protein polymerization; platelet activation; platelet degranulation; blood coagulation; response to calcium ion; signal transduction
|
|
Reference #:
P02679 (UniProtKB)
|
| Alt. Names/Synonyms: FGG; FIBG; Fibrinogen gamma chain; fibrinogen, gamma chain; fibrinogen, gamma polypeptide |
| Gene Symbols: FGG |
|
Molecular weight: 51,512 Da
|
|
Basal Isoelectric point: 5.37
Predict pI for various phosphorylation states
|
