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Protein Page:
SMARCA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SMARCA1 Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with PRLR. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription regulation; Cell development/differentiation; EC 3.6.1.-; EC 3.6.4.-; Helicase
Cellular Component: nuclear chromatin; nucleus
Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; nucleosome binding; helicase activity; ATP binding
Biological Process: ATP catabolic process; neuron differentiation; chromatin remodeling; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA strand renaturation; ATP-dependent chromatin remodeling; brain development
Reference #:  P28370 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase SMARCA1; DKFZp686D1623; FLJ41547; ISWI; Nucleosome-remodeling factor subunit SNF2L; NURF140; Probable global transcription activator SNF2L1; SMARCA1; SMCA1; SNF2-like 1; SNF2L; SNF2L1; SNF2LB; sucrose nonfermenting 2-like protein 1; SWI; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; SWI2
Gene Symbols: SMARCA1
Molecular weight: 122,605 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMARCA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S62 KKKEKNVSSFQLKLA
0 2 T102-p FEFLLKQtELFAHFI
0 2 S112-p FAHFIQPsAQKsPts
0 10 S116-p IQPsAQKsPtsPLNM
0 7 T118-p PsAQKsPtsPLNMKL
0 15 S119-p sAQKsPtsPLNMKLG
0 1 S137-p IKKDEKQsLIsAGDy
0 1 S140-p DEKQsLIsAGDyRHR
0 1 Y144-p sLIsAGDyRHRRTEQ
0 2 K179-ub EVSPSYVkGGPLRDY
0 1 T374-p DFDSWFDtKNCLGDQ
0 3 Y416-p PKKEIKIyLGLsKMQ
0 1 S420-p IKIyLGLsKMQREWy
0 1 Y427-p sKMQREWyTkILMKD
0 1 K429-ub MQREWyTkILMKDID
0 1 K662-ub QQSNKLAkEEMLQMI
0 1 K709 EMNERLQKMGESSLR
0 1 S725-p FRMDIEQsLYKFEGE
0 7 Y757-p KRERKANyAVDAYFR
0 4 S770-p FREALRVsEPKIPKA
0 1 K851-ac EETEEKEkLLTQGFT
0 1 K851-ub EETEEKEkLLTQGFT
0 1 K874-ub QFIKANEkYGRDDID
0 1 Y954 FHQLRIQYGTSKGKN
0 1 Y985-p GFDRENVyEELRQCV
0 1 K1038-ac EERERAEkkKRATKT
0 1 K1039-ac ERERAEkkKRATKTP
  mouse

 
S61-p EKKEKITsPFQLKLA
T106 FEFLLKQTELFAHFI
S116-p FAHFIQPsAQKSPTs
S120 IQPsAQKSPTsPLNM
T122 PsAQKSPTsPLNMKL
S123-p sAQKSPTsPLNMKLA
S141 VKKDDKQSLISVGDY
S144 DDKQSLISVGDYRHR
Y148 SLISVGDYRHRRTEQ
K183 EVSPSYVKGGPLRDY
T378 DFDSWFDTKNCLGDQ
Y420 PKKEIKIYLGLSKMQ
S424 IKIYLGLSKMQREWY
Y431 SKMQREWYTKILMKD
K433 MQREWYTKILMKDID
K654 QQSNKLAKEEMLQMI
K701-ac EMNERMQkMGESSLR
S717 FRMDLEQSLYKFEGE
Y749 KRERKANYAVDAYFR
S762-p FREALRVsEPKIPKA
K843 QETEEKDKLLTQGFT
K843 QETEEKDKLLTQGFT
K866 QFIKANEKYGRDDID
Y946-p FHQLRIQyGTSKGKN
Y977 GFDRENVYEELRQCV
K1030 EERERAEKKKRATKT
K1031 ERERAEKKKRATKTP
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