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SMARCA1 (human)

Overview SMARCA1 Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Part of the CECR2-containing-remodeling factor (CERF) complex which contains CECR2 and SMARCA1. Interacts with PRLR. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.6.1.-; Helicase; EC 3.6.4.-; Transcription regulation; Cell development/differentiation Cellular Component: nucleus Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; nucleosome binding; helicase activity; ATP binding Biological Process: neuron differentiation; chromatin remodeling; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA strand renaturation; ATP-dependent chromatin remodeling; brain development Reference #:  P28370 (UniProtKB) Alt. Names/Synonyms: ATP-dependent helicase SMARCA1; DKFZp686D1623; FLJ41547; global transcription activator homologous sequence; ISWI; Nucleosome-remodeling factor subunit SNF2L; NURF140; Probable global transcription activator SNF2L1; SMARCA1; SMCA1; SNF2-like 1; SNF2L; SNF2L1; SNF2LB; sucrose nonfermenting 2-like protein 1; SWI; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1; SWI2 Gene Symbols: SMARCA1 Molecular weight: 122,605 Da Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SMARCA1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		S62-p	KKKEKNVsSFQLKLA
0	1		T102-p	FEFLLKQtELFAHFI
0	6		S116-p	IQPSAQKsPtsPLNM
0	4		T118-p	PSAQKsPtsPLNMKL
0	9		S119-p	SAQKsPtsPLNMKLG
0	1		S137-p	IKKDEKQsLIsAGDy
0	1		S140-p	DEKQsLIsAGDyRHR
0	1		Y144-p	sLIsAGDyRHRRTEQ
0	2		K179-u	EVSPSYVkGGPLRDY
0	1		T374-p	DFDSWFDtKNCLGDQ
0	3		Y416-p	PKKEIKIyLGLsKMQ
0	1		S420-p	IKIyLGLsKMQREWy
0	1		Y427-p	sKMQREWyTkILMKD
0	1		K429-u	MQREWyTkILMKDID
0	1		K662-u	QQSNKLAkEEMLQMI
0	1		K709	EMNERLQKMGESSLR
0	1		S725-p	FRMDIEQsLYKFEGE
0	3		S770-p	FREALRVsEPKIPKA
0	1		K851-a	EETEEKEkLLTQGFT
0	1		K851-u	EETEEKEkLLTQGFT
0	1		K874-u	QFIKANEkYGRDDID
0	1		Y954	FHQLRIQYGTSKGKN
0	1		Y985-p	GFDRENVyEELRQCV
0	1		K1038-a	EERERAEkkKRATKT
0	1		K1039-a	ERERAEkkKRATKTP

	mouse
S61-p	EKKEKITsPFQLKLA
T106	FEFLLKQTELFAHFI
S120	IQPSAQKSPTsPLNM
T122	PSAQKSPTsPLNMKL
S123-p	SAQKSPTsPLNMKLA
S141	VKKDDKQSLISVGDY
S144	DDKQSLISVGDYRHR
Y148	SLISVGDYRHRRTEQ
K183	EVSPSYVKGGPLRDY
T378	DFDSWFDTKNCLGDQ
Y420	PKKEIKIYLGLSKMQ
S424	IKIYLGLSKMQREWY
Y431	SKMQREWYTKILMKD
K433	MQREWYTKILMKDID
K654	QQSNKLAKEEMLQMI
K701-a	EMNERMQkMGESSLR
S717	FRMDLEQSLYKFEGE
S762-p	FREALRVsEPKIPKA
K843	QETEEKDKLLTQGFT
K843	QETEEKDKLLTQGFT
K866	QFIKANEKYGRDDID
Y946-p	FHQLRIQyGTSKGKN
Y977	GFDRENVYEELRQCV
K1030	EERERAEKKKRATKT
K1031	ERERAEKKKRATKTP

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