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Protein Page:
BORA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BORA Required for the activation of AURKA at the onset of mitosis. Interacts with AURKA. Belongs to the BORA family. Note: This description may include information from UniProtKB.
Protein type: Activator protein
Chromosomal Location of Human Ortholog: 13q22.1
Cellular Component: cytosol
Molecular Function: protein binding; protein kinase binding
Biological Process: mitosis; regulation of protein localization; regulation of mitosis; mitotic cell cycle; G2/M transition of mitotic cell cycle
Reference #:  Q6PGQ7 (UniProtKB)
Alt. Names/Synonyms: aurora borealis; BORA; C13orf34; chromosome 13 open reading frame 34; FLJ22624; HsBora; Protein aurora borealis
Gene Symbols: BORA
Molecular weight: 61,203 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BORA

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S274‑p, S278‑p, S497‑p, T501‑p
molecular association, regulation: S252‑p, S274‑p, S278‑p, S497‑p, T501‑p
protein degradation: S274‑p, S278‑p, S497‑p, T501‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y31-p PFESPSDySNLHEQt
0 1 T38-p ySNLHEQtLAsPSVF
1 2 S41-p LHEQtLAsPSVFKST
1 4 T52-p FKSTKLPtPGKFRWS
0 1 Y82-p DIHRQALyLSHSRID
0 1 K95-ac IDKDVEDkRQkAIEE
0 1 K98-ac DVEDkRQkAIEEFFT
0 1 K106-ac AIEEFFTkDVIVPsP
1 1 S112-p TkDVIVPsPWTDHEG
0 1 S135-p SKCTNINsDsPVGKK
0 4 S137-p CTNINsDsPVGKKLT
0 2 S183-p ADEFADQsPGNLsSS
0 2 S188-p DQsPGNLsSSsLRRK
0 3 S191-p PGNLsSSsLRRKLFL
0 1 S212 SDSLPSASPGSPHSG
0 1 S215 LPSASPGSPHSGVQT
0 4 S239-p LSPVKCRsPLQTPSS
1 3 S252-p SSGQFSSsPIQASAK
1 2 S270-p LGSITSPsPISsPTF
2 2 S274-p TSPsPISsPTFsPIE
2 2 S278-p PISsPTFsPIEFQIG
0 1 T296-p LSEQRKFtVHsPDAs
0 6 S299-p QRKFtVHsPDAsSGT
0 2 S303-p tVHsPDAsSGTNSNG
0 1 S318-p ITNPCIRsPYIDGCs
0 9 S325-p sPYIDGCsPIKNWSP
0 1 K328 IDGCsPIKNWSPMRL
0 1 S331 CsPIKNWSPMRLQMY
0 4 Q336 NWSPMRLQMYsGGTQ
0 1 S339-p PMRLQMYsGGTQYRT
0 1 T354 SVIQIPFTLETQGED
0 3 T407 VVTAMSVTQNQSSAS
0 2 S411 MSVTQNQSSASEKEL
0 2 T432-p EREKDNNtVDMVDPI
0 1 T445-p PIEIADEttWIKEPV
0 1 T446-p IEIADEttWIKEPVD
2 0 S497-p SSNIQMDsGYNtQNC
2 0 T501-p QMDsGYNtQNCGSNI
0 1 S552-p RCWMKTAsPFQCSsP
0 2 S558-p AsPFQCSsP______
  mouse

 
Y31 PFESPSDYSNLHEQT
T38 YSNLHEQTLASPSIF
S41 LHEQTLASPSIFKST
T52 FKSTKLPTPGKFRWS
Y82 EIHRQASYLRLSRID
K95 IDKDVEDKRQKAIEE
K98 DVEDKRQKAIEEFFT
K106 AIEEFFTKDVIVPSP
S112 TKDVIVPSPWTDHDG
D135 SKCLSSHDDSPDGKK
S137 CLSSHDDSPDGKKPS
T183 EEDFVAHTPGNLSSS
S188 AHTPGNLSSSSLRRK
S191 PGNLSSSSLRRKLFL
S212-p CDPLPSPsPGsPPCS
S215-p LPSPsPGsPPCSARG
- gap
S231-p LEGQFSSsPIQNSVK
S250 GSVTTSPSAISSPTF
S254 TSPSAISSPTFSPIA
S258 AISSPTFSPIALQGG
T276 LSEPRKLTFHSPEAS
S279 PRKLTFHSPEASCAT
S283 TFHSPEASCATASTG
S298 IVNPSIRSPYIDGCs
S305-p SPYIDGCsPIkNWsP
K308-ac IDGCsPIkNWsPRRL
S311-p CsPIkNWsPRRLrGG
R316-m1 NWsPRRLrGGPQCLS
- under review  
T331-p SLVRIPFtLEAHSED
T368-p VVTAMSVtQSHsGIA
S372-p MSVtQSHsGIAEKER
T393 ESERENDTVDMVDPT
S406 PTDTVAESTWIKEPV
T407 TDTVAESTWIKEPVD
S458 SSAIQMNSDYNTQTC
T462 QMNSDYNTQTCVSNI
R518 RCWMKSPRPSQCSRP
R524 PRPSQCSRP______
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