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SEC24A (human)

Overview SEC24A Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol Molecular Function: zinc ion binding Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; membrane organization and biogenesis Reference #:  O95486 (UniProtKB) Alt. Names/Synonyms: Protein transport protein Sec24A; SC24A; SEC24 family, member A (S. cerevisiae); SEC24 related gene family, member A; SEC24-related protein A; SEC24A Gene Symbols: SEC24A Molecular weight: 119,749 Da Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SEC24A 2NUP - B=326-1078 (human) 2NUT - B=326-1078 (human) 3EGD - B=346-1093 (human) 3EGX - B=346-1093 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2NUP 2NUT 3EGD 3EGX  |  Phospho3D  |  DISEASE  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S156-p	TNHCPRAsSQPTVSG
0	1		S184-p	GYPSLQNsFIKSGPS
0	7		S229-p	RALTPLTsSYRDVPQ
0	1		Y263-p	SMVVHSSyDEIEGGG
0	2		T363-p	ERNMLPStPLKPPVP
0	1		K378-u	NLHEDIQkLNCNPEL
0	1		K402	QTQALLNKAKLPLGL
0	1		S426-p	QLPVVTSsTIVRCRS
0	1		K608	TLPQMFTKTLETQSA
0	2		K650-u	TLGVGALkPREEPNH
0	1		K662	PNHRSSAKDIHMTPS
0	1		Y708-p	SLGCISRySAGSVYY
0	2		K813-a	ALLYTSSkGERRIRV
0	1		K910	VLALLKQKSFQTGTN
0	1		K977	ILQLSVEKLSRDGAF
0	2		Y1053-p	RPFFPILyVIRDESP
0	1		K1062-u	IRDESPMkANFLQNM

	mouse
-	gap
S183	GDPALQTSFKKPGSA
T227-p	RGPAPQKtPPRAAPP
Y261	STAAHNTYDEIEGGG
T360	ERNMLPSTPLQPPVP
K375-u	NLLEDIQkLNCNPEL
K399-u	QTQALLNkAKLPLGL
S423	QLPVVTSSTIVRCRS
K605-u	TLPQMFTkTLETQSA
K647-u	TLGVGALkPREEPNQ
K659-u	PNQRSSAkEIHLTPS
Y705	SLGCISRYSAGSVYY
K810	ALLYTSSKGERRIRV
K907-u	VLALLKQkSFQTGTS
K974-u	ILQLSVEkLSRDGAF
Y1050-p	RPFFPVLyVIREESL
K1059	IREESLMKAAFLQSL

	rat
-	gap
S183	GDPALQTSFKKPGSA
T227	RGPVPQKTPPRAAFP
Y260	GSAAHSTYDEIEGGG
T359	ERNMLPSTPLQPPVP
K374	NLLEDVQKLNCNPEL
K398	QTQALLNKAKLPLGL
S422	QLPVVTSSTIVRCRS
K604	TLPQMFTKTLETQSA
K646	TLGVGALKPREEPNQ
K658	PNQRSSAKEIHLTPS
Y704	SLGCISRYSAGSVYY
K809	ALLYTSSKGERRIRV
K906	VLALLKQKSFQTGTN
K973	ILQLSVEKLSRDGAF
Y1049	RPFFPILYVIREESL
K1058	IREESLMKAAFLQNL

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