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Protein Page:
SEC24A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SEC24A Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. SEC24A is capable of forming heterodimers with SEC24B and SEC24C. Interacts with TMED2. Expressed in fibroblasts, hepatocytes, and lymphocytes. Belongs to the SEC23/SEC24 family. SEC24 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; COPII vesicle coat; perinuclear region of cytoplasm; cytosol
Molecular Function: zinc ion binding
Biological Process: COPII coating of Golgi vesicle; intracellular protein transport; antigen processing and presentation of peptide antigen via MHC class I; ER to Golgi vesicle-mediated transport; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Reference #:  O95486 (UniProtKB)
Alt. Names/Synonyms: Protein transport protein Sec24A; SC24A; SEC24 family, member A (S. cerevisiae); SEC24 related gene family, member A; SEC24-related protein A; SEC24A
Gene Symbols: SEC24A
Molecular weight: 119,749 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SEC24A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S156-p TNHCPRAsSQPTVSG
0 1 S184-p GYPSLQNsFIKSGPS
0 8 S229 RALTPLTSSYRDVPQ
0 1 Y263-p SMVVHSSyDEIEGGG
0 2 T363-p ERNMLPStPLKPPVP
0 1 K378 NLHEDIQKLNCNPEL
0 2 T389-p NPELFRCtLtsIPQt
0 1 T391-p ELFRCtLtsIPQtQA
0 1 S392-p LFRCtLtsIPQtQAL
0 1 T396-p tLtsIPQtQALLNKA
0 1 K402 QtQALLNKAKLPLGL
0 1 S426-p QLPVVTSsTIVRCRS
0 1 K608 TLPQMFTKTLETQSA
0 2 K650-ub TLGVGALkPREEPNH
0 1 K662 PNHRSSAKDIHMTPS
0 1 K674 TPSTDFYKKLALDCS
0 1 K674 TPSTDFYKKLALDCS
0 1 Y708-p SLGCISRySAGSVYY
0 2 K813-ac ALLYTSSkGERRIRV
0 1 K910 VLALLKQKSFQTGTN
0 1 K977 ILQLSVEKLSRDGAF
0 2 Y1053-p RPFFPILyVIRDESP
0 1 K1062-ub IRDESPMkANFLQNM
  mouse

 
- gap
S183 GDPALQTSFKKPGSA
T227-p RGPAPQKtPPRAAPP
Y261 STAAHNTYDEIEGGG
T360 ERNMLPSTPLQPPVP
K375-ub NLLEDIQkLNCNPEL
T386 NPELFRCTLTSVPQT
T388 ELFRCTLTSVPQTQA
S389 LFRCTLTSVPQTQAL
T393 TLTSVPQTQALLNkA
K399-ub QTQALLNkAKLPLGL
S423 QLPVVTSSTIVRCRS
K605-ub TLPQMFTkTLETQSA
K647-ub TLGVGALkPREEPNQ
K659-ub PNQRSSAkEIHLTPS
K671-ac TPSTDFYkKLALDCS
K671-sc TPSTDFYkKLALDCS
Y705 SLGCISRYSAGSVYY
K810 ALLYTSSKGERRIRV
K907-ub VLALLKQkSFQTGTS
K974-ub ILQLSVEkLSRDGAF
Y1050-p RPFFPVLyVIREESL
K1059 IREESLMKAAFLQSL
  rat

 
- gap
S183 GDPALQTSFKKPGSA
T227 RGPVPQKTPPRAAFP
Y260 GSAAHSTYDEIEGGG
T359 ERNMLPSTPLQPPVP
K374 NLLEDVQKLNCNPEL
T385 NPELFRCTLTSVPQT
T387 ELFRCTLTSVPQTQA
S388 LFRCTLTSVPQTQAL
T392 TLTSVPQTQALLNKA
K398 QTQALLNKAKLPLGL
S422 QLPVVTSSTIVRCRS
K604 TLPQMFTKTLETQSA
K646 TLGVGALKPREEPNQ
K658 PNQRSSAKEIHLTPS
K670 TPSTDFYKKLALDCS
K670 TPSTDFYKKLALDCS
Y704 SLGCISRYSAGSVYY
K809 ALLYTSSKGERRIRV
K906 VLALLKQKSFQTGTN
K973 ILQLSVEKLSRDGAF
Y1049 RPFFPILYVIREESL
K1058 IREESLMKAAFLQNL
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