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CA12 (human)

Overview CA12 Reversible hydration of carbon dioxide. Homodimer. Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA), benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4- carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2- aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide) and Foscarnet (phosphonoformate trisodium salt). Belongs to the alpha-carbonic anhydrase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase Cellular Component: integral to membrane; plasma membrane Molecular Function: carbonate dehydratase activity; zinc ion binding Biological Process: bicarbonate transport; one-carbon compound metabolic process Reference #:  O43570 (UniProtKB) Alt. Names/Synonyms: CA-XII; CA12; CAH12; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII; carbonic dehydratase; CAXII; FLJ20151; HsT18816; Tumor antigen HOM-RCC-3.1.3 Gene Symbols: CA12 Molecular weight: 39,451 Da Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CA12 1JCZ - A/B=30-291 (human) 1JD0 - A/B=30-291 (human) 4HT2 - A/D/C/B=30-291 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1JCZ 1JD0 4HT2  |  ENZYME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	31		Y342-p	GDNKGVIyKPATKME
0	1		K343	DNKGVIyKPATKMET

	mouse
Y342-p	GDNKGVIykPAIKKE
K343-u	DNKGVIykPAIKKEA

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