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Protein Page:
EphB6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EphB6 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Eph family
Cellular Component: integral to plasma membrane; extracellular region
Molecular Function: ephrin receptor activity; receptor activity; ATP binding
Biological Process: calcium ion homeostasis; ephrin receptor signaling pathway; protein amino acid phosphorylation
Reference #:  O15197 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B6; EPHB6; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine-protein kinase-defective receptor EPH-6
Gene Symbols: EPHB6
Molecular weight: 110,700 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphB6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R125 GVSGGTCRETFTLYY
0 1 K154-m1 WHLKRWTkVDTIAAD
2 1 Y628 RKRRGTGYTEQLQQy
2 8 Y635-p YTEQLQQySSPGLGV
0 1 S636 TEQLQQySSPGLGVK
0 4 S637 EQLQQySSPGLGVKy
1 4 Y644-p SPGLGVKyyIDPSTy
2 5 Y645-p PGLGVKyyIDPSTyE
2 16 Y651-p yyIDPSTyEDPCQAI
0 1 A668 LAREVDPAyIKIEEV
0 2 Y669-p AREVDPAyIKIEEVI
1 1 Q697 QPRGRREQTVAIQAL
1 1 G708 IQALWAGGAESLQMT
1 1 Y785 GVAAAMQYLSSFAFV
1 1 F791 QYLSSFAFVHRSLSA
1 1 - gap
1 1 H835 AAPEVIAHGKHTTSS
1 1 Y965 SAIGLECYQDNFSKF
  mouse

 
R126-m2 GVSGGTCrETFTLYY
K155 WHLKRWTKVDTIAAD
Y621 RKRRGTGYTEQLQQy
Y628-p YTEQLQQyssPGLGV
S629-p TEQLQQyssPGLGVK
S630-p EQLQQyssPGLGVKY
Y637 sPGLGVKYYIDPSTy
Y638 PGLGVKYYIDPSTyD
Y644-p YYIDPSTyDDPCQAI
T661-p LAREVDPtyIKIEEV
Y662-p AREVDPtyIKIEEVI
Q690 QPRGRREQAVAIQAL
G701 IQALWAGGAESLKMT
Y778 GVAAAMQYLSSFAFV
F784 QYLSSFAFVHRALSA
- gap
H828 AAPEVITHGKYTTSS
Y958 SAIGLECYQDNFSKF
  rat

 
R125 GVSGGTCRETFTLYY
K154 WHLKRWTKVDTIAAD
Y620 RKRRGTGYTEQLQQY
Y627 YTEQLQQYSSPGLGV
S628 TEQLQQYSSPGLGVK
S629 EQLQQYSSPGLGVKY
Y636 SPGLGVKYYIDPSTy
Y637 PGLGVKYYIDPSTyD
Y643-p YYIDPSTyDDPCQAI
T660 LAREVDPTYIKIEEV
Y661 AREVDPTYIKIEEVI
Q689 QPRGRREQAVAIQAL
G700 IQALWAGGAESLKMT
Y777 GVAAAMQYLSSFAFV
F783 QYLSSFAFVHRALSA
- gap
H827 AAPEVITHGKYTTSS
Y957 SAIGLECYQDNFSKF
  chicken

 
K119 RTVASTCKETFTLYY
K148 WHEGPWTKVDTIAAD
Y594-p SKRRETPyTDRLQQy
Y601-p yTDRLQQyISTRGLG
S603 DRLQQyISTRGLGVK
T604 RLQQyISTRGLGVKy
Y611-p TRGLGVKyyIDPSTy
Y612-p RGLGVKyyIDPSTyE
Y618-p yyIDPSTyEDPNEAI
S635 FAKEIDVSFIKIEEV
F636 AKEIDVSFIKIEEVI
Y664-p KHPGKREyTVAIKTL
Y675-p IKTLKSGyTDEQRRE
Y752-p GIAAGMRyLSDMNyV
Y758-p RyLSDMNyVHRDLAA
Y796-p DDASNPTyTGALGCK
Y816-p TAPEAVQyRKFTSSS
Y946-p DAIKMGRyKENFDQA
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