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Protein Page:
EphB6 (human)

Overview
EphB6 Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; Eph family
Cellular Component: integral to plasma membrane; extracellular region
Molecular Function: ephrin receptor activity; receptor activity; ATP binding
Biological Process: calcium ion homeostasis
Reference #:  O15197 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B6; EPHB6; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine-protein kinase-defective receptor EPH-6
Gene Symbols: EPHB6
Molecular weight: 110,700 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphB6

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 1 Y628 RKRRGTGYTEQLQQy
2 8 Y635-p YTEQLQQySSPGLGV
0 4 S637 EQLQQySSPGLGVKy
1 4 Y644-p SPGLGVKyyIDPSTy
2 5 Y645-p PGLGVKyyIDPSTyE
2 17 Y651-p yyIDPSTyEDPCQAI
0 2 Y669-p AREVDPAyIKIEEVI
1 1 Q697 QPRGRREQTVAIQAL
1 1 G708 IQALWAGGAESLQMT
1 1 Y785 GVAAAMQYLSSFAFV
1 1 F791 QYLSSFAFVHRSLSA
1 1 - gap
1 1 H835 AAPEVIAHGKHTTSS
1 1 Y965 SAIGLECYQDNFSKF
  mouse

 
Y621 RKRRGTGYTEQLQQy
Y628-p YTEQLQQySsPGLGV
S630-p EQLQQySsPGLGVKY
Y637 sPGLGVKYYIDPSTy
Y638 PGLGVKYYIDPSTyD
Y644-p YYIDPSTyDDPCQAI
Y662-p AREVDPTyIKIEEVI
Q690 QPRGRREQAVAIQAL
G701 IQALWAGGAESLKMT
Y778 GVAAAMQYLSSFAFV
F784 QYLSSFAFVHRALSA
- gap
H828 AAPEVITHGKYTTSS
Y958 SAIGLECYQDNFSKF
  rat

 
Y620 RKRRGTGYTEQLQQY
Y627 YTEQLQQYSSPGLGV
S629 EQLQQYSSPGLGVKY
Y636 SPGLGVKYYIDPSTy
Y637 PGLGVKYYIDPSTyD
Y643-p YYIDPSTyDDPCQAI
Y661 AREVDPTYIKIEEVI
Q689 QPRGRREQAVAIQAL
G700 IQALWAGGAESLKMT
Y777 GVAAAMQYLSSFAFV
F783 QYLSSFAFVHRALSA
- gap
H827 AAPEVITHGKYTTSS
Y957 SAIGLECYQDNFSKF
  chicken

 
Y594-p SKRRETPyTDRLQQy
Y601-p yTDRLQQyISTRGLG
T604 RLQQyISTRGLGVKy
Y611-p TRGLGVKyyIDPSTy
Y612-p RGLGVKyyIDPSTyE
Y618-p yyIDPSTyEDPNEAI
F636 AKEIDVSFIKIEEVI
Y664-p KHPGKREyTVAIKTL
Y675-p IKTLKSGyTDEQRRE
Y752-p GIAAGMRyLSDMNyV
Y758-p RyLSDMNyVHRDLAA
Y796-p DDASNPTyTGALGCK
Y816-p TAPEAVQyRKFTSSS
Y946-p DAIKMGRyKENFDQA
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