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EphB4 (human)

Overview EphB4 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Note: This description may include information from UniProtKB. Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.1.112; TK group; Eph family Cellular Component: cell surface; integral to plasma membrane Molecular Function: protein binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: heart morphogenesis; cell migration during sprouting angiogenesis; protein amino acid autophosphorylation; ephrin receptor signaling pathway; angiogenesis; cell adhesion Reference #:  P54760 (UniProtKB) Alt. Names/Synonyms: EPH receptor B4; EPHB4; ephrin receptor EphB4; Ephrin type-B receptor 4; hepatoma transmembrane kinase; HTK; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11 Gene Symbols: EPHB4 Molecular weight: 108,270 Da Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases

Select Structure to View Below EphB4 2BBA - A=17-196 (human) 2E7H - A=434-529 (human) 2HLE - A=17-196 (human) 2QKQ - A/B=896-977 (human) 2VWU - A=598-887 (human) 2VWV - A=598-899 (human) 2VWW - A=598-899 (human) 2VWX - A=598-899 (human) 2VWY - A=598-899 (human) 2VWZ - A=598-899 (human) 2VX0 - A=598-899 (human) 2VX1 - A=598-899 (human) 2X9F - A=598-899 (human) 2XVD - A=598-899 (human) 4AW5 - A=605-890 (human) 4BB4 - A=598-899 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 4AW5 4BB4  |  ENZYME 2.7.1.112 2.7.10.1  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T140	NPYIKVDTVAAEHLT
0	1		T147	TVAAEHLTRKRPGAE
0	1		K196-a	SLHLFYKkCAQLTVN
0	1		T321-p	DPRGAPCttPPSAPR
0	1		T322-p	PRGAPCttPPSAPRS
0	1		S332-p	SAPRSVVsRLNGsSL
0	1		S337-p	VVsRLNGsSLHLEWS
0	1		Y357-p	GGREDLTyALRCREC
0	1		T544-p	QLALIAGtAVVGVVL
0	173		Y574-p	SNGREAEysDKHGQy
0	26		S575-p	NGREAEysDKHGQyL
0	88		Y581-p	ysDKHGQyLIGHGtK
0	8		T587-p	QyLIGHGtKVyIDPF
0	160		Y590-p	IGHGtKVyIDPFtyE
0	15		T595-p	KVyIDPFtyEDPNEA
0	213		Y596-p	VyIDPFtyEDPNEAV
0	23		Y614-p	AKEIDVSyVKIEEVI
0	3		S762-p	KVSDFGLsRFLEENs
0	14		S769-p	sRFLEENssDPtyts
0	4		S770-p	RFLEENssDPtytss
0	19		T773-p	EENssDPtytssLGG
0	249		Y774-p	ENssDPtytssLGGK
0	3		T775-p	NssDPtytssLGGKI
0	2		S776-p	ssDPtytssLGGKIP
0	2		S777-p	sDPtytssLGGKIPI
0	2		S872-p	PRFPQVVsALDKMIR
0	9		Y906-p	LDQRQPHySAFGsVG
0	2		S911-p	PHySAFGsVGEWLRA
0	1		Y924-p	RAIKMGRyEESFAAA
0	1		K973-u	QHMKSQAkPGtPGGT
0	6		T976-p	KSQAkPGtPGGTGGP
0	362		Y987-p	TGGPAPQy_______

	mouse
T140-p	NPYIKVDtVAAEHLt
T147-p	tVAAEHLtRKRPGAE
K196	SLHLFYKKCSWLITN
T321	DPRSSPCTTPPSAPR
T322	PRSSPCTTPPSAPRS
H332	SAPRSVVHHLNGSTL
S337	VVHHLNGSTLRLEWS
Y357	GGREDLTYAVRCREC
T544	QLALIAGTAVVGVVL
Y574-p	SNGREVEysDKHGQy
S575-p	NGREVEysDKHGQyL
Y581-p	ysDKHGQyLIGHGtK
T587-p	QyLIGHGtKVyIDPF
Y590-p	IGHGtKVyIDPFtyE
T595-p	KVyIDPFtyEDPNEA
Y596-p	VyIDPFtyEDPNEAV
Y614-p	AKEIDVSyVKIEEVI
S762-p	KVSDFGLsRFLEENs
S769-p	sRFLEENssDPtyTS
S770-p	RFLEENssDPtyTSS
T773-p	EENssDPtyTSSLGG
Y774-p	ENssDPtyTSSLGGK
T775	NssDPtyTSSLGGKI
S776	ssDPtyTSSLGGKIP
S777	sDPtyTSSLGGKIPI
S872	PRFPQVVSALDKMIR
Y906-p	LDQRQPHySAFGSVG
S911	PHySAFGSVGEWLRA
Y924	RAIKMGRYEESFAAA
K973	QHMKSQAKPGAPGGT
A976	KSQAKPGAPGGTGGP
F987	TGGPAQQF_______

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