Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 18.104.22.168; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 22.214.171.124; TK group; Eph family
Cellular Component: cell surface; integral to plasma membrane
Molecular Function: protein binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: heart morphogenesis; cell migration during sprouting angiogenesis; protein amino acid autophosphorylation; ephrin receptor signaling pathway; angiogenesis; cell adhesion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.