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Protein Page:
EphB4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EphB4 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.1.112; EC 2.7.10.1; TK group; Eph family
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: integral to plasma membrane
Molecular Function: protein binding; ephrin receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: heart morphogenesis; peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; protein amino acid autophosphorylation; ephrin receptor signaling pathway; angiogenesis; cell adhesion
Reference #:  P54760 (UniProtKB)
Alt. Names/Synonyms: EPH receptor B4; EPHB4; ephrin receptor EphB4; Ephrin type-B receptor 4; hepatoma transmembrane kinase; HTK; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11
Gene Symbols: EPHB4
Molecular weight: 108,270 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
Select Structure to View Below

EphB4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T140 NPYIKVDTVAAEHLT
0 1 T147 TVAAEHLTRKRPGAE
0 1 K196-ac SLHLFYKkCAQLTVN
0 1 T321-p DPRGAPCttPPSAPR
0 1 T322-p PRGAPCttPPSAPRS
0 1 S332-p SAPRSVVsRLNGsSL
0 1 S337-p VVsRLNGsSLHLEWS
0 1 Y357-p GGREDLTyALRCREC
0 1 S502 RGLKRGASYLVQVRA
0 1 T544-p QLALIAGtAVVGVVL
0 185 Y574-p SNGREAEysDKHGQy
0 25 S575-p NGREAEysDKHGQyL
0 94 Y581-p ysDKHGQyLIGHGtK
0 9 T587-p QyLIGHGtKVyIDPF
2 163 Y590-p IGHGtKVyIDPFtyE
0 15 T595-p KVyIDPFtyEDPNEA
3 211 Y596-p VyIDPFtyEDPNEAV
0 29 Y614-p AKEIDVSyVKIEEVI
0 3 S762-p KVSDFGLsRFLEENs
0 18 S769-p sRFLEENssDPtyts
0 6 S770-p RFLEENssDPtytss
0 19 T773-p EENssDPtytssLGG
1 265 Y774-p ENssDPtytssLGGK
0 3 T775-p NssDPtytssLGGKI
0 2 S776-p ssDPtytssLGGKIP
0 4 S777-p sDPtytssLGGKIPI
0 3 S872-p PRFPQVVsALDKMIR
0 13 Y906-p LDQRQPHySAFGsVG
0 2 S911-p PHySAFGsVGEWLRA
0 1 Y924-p RAIKMGRyEESFAAA
0 1 S943-p FELVSQIsAEDLLRI
0 1 S964-p HQKKILAsVQHMKSQ
0 1 K973-ub QHMKSQAkPGtPGGT
0 11 T976-p KSQAkPGtPGGTGGP
0 355 Y987-p TGGPAPQy_______
  mouse

 
T140-p NPYIKVDtVAAEHLt
T147-p tVAAEHLtRKRPGAE
K196 SLHLFYKKCSWLITN
T321 DPRSSPCTTPPSAPR
T322 PRSSPCTTPPSAPRS
H332 SAPRSVVHHLNGSTL
S337 VVHHLNGSTLRLEWS
Y357 GGREDLTYAVRCREC
S502-p RGLKRGAsYLVQVRA
T544 QLALIAGTAVVGVVL
Y574-p SNGREVEysDKHGQy
S575-p NGREVEysDKHGQyL
Y581-p ysDKHGQyLIGHGtK
T587-p QyLIGHGtKVyIDPF
Y590-p IGHGtKVyIDPFtyE
T595-p KVyIDPFtyEDPNEA
Y596-p VyIDPFtyEDPNEAV
Y614-p AKEIDVSyVKIEEVI
S762-p KVSDFGLsRFLEENs
S769-p sRFLEENssDPtyTS
S770-p RFLEENssDPtyTSS
T773-p EENssDPtyTSSLGG
Y774-p ENssDPtyTSSLGGK
T775 NssDPtyTSSLGGKI
S776 ssDPtyTSSLGGKIP
S777 sDPtyTSSLGGKIPI
S872-p PRFPQVVsALDKMIR
Y906-p LDQRQPHySAFGSVG
S911 PHySAFGSVGEWLRA
Y924 RAIKMGRYEESFAAA
S943 FEVVSQISAEDLLRI
S964 HQKKILASVQHMKSQ
K973 QHMKSQAKPGAPGGT
A976 KSQAKPGAPGGTGGP
F987 TGGPAQQF_______
  rat

 
T140 NPYIKVDTVAAEHLT
T147 TVAAEHLTRKRPGAE
K196 SLHLFYKKCSRLVTN
T321 DPRSSPCTTPPSAPR
T322 PRSSPCTTPPSAPRS
H332 SAPRSVVHHLNGSSL
S337 VVHHLNGSSLRLEWS
Y357 GGREDLTYAVRCREC
S511 RGLKQGASYLVQVRA
T553 QLALIAGTAVVGVVL
Y583 SSGREVEYSDKHGQY
S584 SGREVEYSDKHGQYL
Y590 YSDKHGQYLIGHGTK
T596 QYLIGHGTKVYIDPF
Y599 IGHGTKVYIDPFTYE
T604 KVYIDPFTYEDPNEA
Y605 VYIDPFTYEDPNEAV
Y623-p AKEIDVSyVKIEEVI
S771 KVSDFGLSRFLEENs
S778-p SRFLEENsSDPTYTS
S779 RFLEENsSDPTYTSS
T782 EENsSDPTYTSSLGG
Y783 ENsSDPTYTSSLGGK
T784 NsSDPTYTSSLGGKI
S785 sSDPTYTSSLGGKIP
S786 SDPTYTSSLGGKIPI
S881 PRFPQVVSALDKMIR
Y915 LDQRQPHYSAFGSVG
S920 PHYSAFGSVGEWLRA
Y933 RAIKMGRYEESFAAA
S952 FEVVSQISAEDLLRI
S973 HQKKILASVQHMKSQ
K982 QHMKSQAKPGAPGGT
A985 KSQAKPGAPGGTGGP
F996 TGGPTQQF_______
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