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Protein Page:
EphB1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
EphB1 a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Eph family
Cellular Component: axon; integral to plasma membrane; early endosome membrane; dendrite; lipid raft
Molecular Function: protein binding; transmembrane-ephrin receptor activity; axon guidance receptor activity; ATP binding
Biological Process: axon guidance; protein amino acid autophosphorylation; central nervous system projection neuron axonogenesis; optic nerve morphogenesis; regulation of JNK cascade; cell-substrate adhesion; positive regulation of synaptogenesis; camera-type eye morphogenesis; neurogenesis; establishment of cell polarity; ephrin receptor signaling pathway; angiogenesis; detection of temperature stimulus involved in sensory perception of pain; retinal ganglion cell axon guidance
Reference #:  P54762 (UniProtKB)
Alt. Names/Synonyms: EK6; ELK; EPH receptor B1; eph tyrosine kinase 2; EPH-like kinase 6; EPHB1; Ephrin type-B receptor 1; EPHT2; FLJ37986; hEK6; NET; soluble EPHB1 variant 1; Tyrosine-protein kinase receptor EPH-2
Gene Symbols: EPHB1
Molecular weight: 109,885 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EphB1

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y594‑p
cell motility, altered: Y594‑p, Y928‑p
molecular association, regulation: Y594‑p, Y600‑p, Y778‑p, Y928‑p
phosphorylation: Y594‑p, Y928‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 16 Y575-p AYSKEAVySDKLQHy
0 8 Y582-p ySDKLQHysTGRGSP
0 1 S583-p SDKLQHysTGRGSPG
0 5 K592-u GRGSPGMkIyIDPFt
5 127 Y594-p GSPGMkIyIDPFtyE
0 5 T599-p kIyIDPFtyEDPNEA
1 131 Y600-p IyIDPFtyEDPNEAV
0 19 Y634-p AGEFGEVyKGRLKLP
0 5 Y740-p KYLAEMNyVHRDLAA
0 3 S766-p KVSDFGLsRYLQDDT
2 21 Y778-p DDTSDPTyTSSLGGK
0 5 Y798-p TAPEAIAyRKFTSAS
2 0 Y928-p SAIKMVQyRDSFLTA
0 1 S968-p HQKKILNsIHSMRVQ
  mouse

 
Y575-p AYSKEAAySDKLQHy
Y582-p ySDKLQHySTGRGSP
S583 SDKLQHySTGRGSPG
K592 GRGSPGMKIyIDPFt
Y594-p GSPGMKIyIDPFtyE
T599-p KIyIDPFtyEDPNEA
Y600-p IyIDPFtyEDPNEAV
Y634 AGEFGEVYKGRLKLP
Y740 KYLSEMNYVHRDLAA
S766-p KVSDFGLsRYLQDDT
Y778 DDTSDPTYTSSLGGK
Y798 TAPEAIAYRKFTSAS
Y928 SAIKMVQYRDSFLTA
S968 HQKKILSSIHSMRVQ
  rat

 
Y575-p AYSKEAVySDKLQHy
Y582-p ySDKLQHySTGRGSP
S583 SDKLQHySTGRGSPG
K592 GRGSPGMKIyIDPFT
Y594-p GSPGMKIyIDPFTyE
T599 KIyIDPFTyEDPNEA
Y600-p IyIDPFTyEDPNEAV
Y634 AGEFGEVYKGRLKLP
Y740-p KYLSEMNyVHRDLAA
S766 KVSDFGLSRYLQDDT
Y778-p DDTSDPTyTSSLGGK
Y798 TAPEAIAYRKFTSAS
Y928 SAIKMVQYRDSFLTA
S968 HQKKILSSIHSMRVQ
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