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Protein Page:
CD274 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD274 Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to membrane; plasma membrane; endomembrane system; external side of plasma membrane
Molecular Function: protein binding
Biological Process: cell surface receptor linked signal transduction; negative regulation of T cell proliferation; T cell costimulation; immune response; positive regulation of T cell proliferation; signal transduction
Reference #:  Q9NZQ7 (UniProtKB)
Alt. Names/Synonyms: B7 homolog 1; B7-H; B7-H1; B7H1; CD274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; PD-L1; PD1L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1
Gene Symbols: CD274
Molecular weight: 33,275 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD274

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y112-p KLQDAGVyRCMISyG
0 1 Y118-p VyRCMISyGGADyKR
0 1 Y123-p ISyGGADyKRITVKV
0 1 Y134-p TVKVNAPyNKINQRI
0 1 K270-ac KGRMMDVkKCGIQDT
0 1 S283-p DTNSKKQsDTHLEET
  mouse

 
Y112 KLQDAGVYCCIISYG
Y118 VYCCIISYGGADYKR
Y123 ISYGGADYKRITLKV
Y134 TLKVNAPYRKINQRI
E270 QVRMLDVEKCGVEDT
N283 DTSSKNRNDTQFEET
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