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Protein Page:
dectin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
dectin-1 Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: cytoplasm; integral to membrane; external side of plasma membrane
Molecular Function: zymosan receptor activity; opsonin binding; zymosan binding; metal ion binding; carbohydrate binding; MHC protein binding; pattern recognition receptor activity
Biological Process: T cell activation; cell surface pattern recognition receptor signaling pathway; cell recognition; phagocytosis, recognition; defense response to protozoan; positive regulation of tumor necrosis factor production; cell-cell adhesion; leukocyte activation during immune response; positive regulation of phagocytosis; innate immune response; carbohydrate mediated signaling; inflammatory response; detection of yeast; phagocytosis, engulfment
Reference #:  Q9BXN2 (UniProtKB)
Alt. Names/Synonyms: Beta-glucan receptor; BGR; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; CANDF4; CLC7A; CLEC7A; CLECSF12; DC-associated C-type lectin 1; Dectin-1; DECTIN1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1
Gene Symbols: CLEC7A
Molecular weight: 27,627 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

dectin-1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T66 VIAVVLGTMAIWRSN
0 1 Y132-p IIYEKSCyLFSMSLN
0 3 K157-ub QLGSNLLkIDsSNEL
0 2 S160-p SNLLkIDsSNELGFI
0 1 S161 NLLkIDsSNELGFIV
0 2 K169-ub NELGFIVkQVSSQPD
0 1 N219 TQENPSPNCVWIHVS
  dectin-1 iso3  
T66 VIAVVLGTMAIWRSN
Y132 IIYEKSCYLFSMSLN
K157 QLGSNLLKIDssNEL
S160-p SNLLKIDssNELISD
S161-p NLLKIDssNELISDQ
- gap
S171-p LISDQNHsYPRKPIS
  dectin-1 iso9  
T66-p VIAVVLGtMAGFKAV
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
A66 VVAAVLGALGEYGHN
Y131 IMHGKSCYLFSFSGN
K156 QLGAHLLKIDNSKEF
N159 AHLLKIDNSKEFEFI
S160 HLLKIDNSKEFEFIE
S168 KEFEFIESQTSSHRI
N218 PQESLLHNCVWIHGS
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