Home

dectin-1 (human)

Overview dectin-1 Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: cytoplasm; integral to membrane; external side of plasma membrane Molecular Function: zymosan receptor activity; opsonin binding; metal ion binding; zymosan binding; MHC protein binding; carbohydrate binding; pattern recognition receptor activity Biological Process: T cell activation; cell surface pattern recognition receptor signaling pathway; phagocytosis, recognition; cell recognition; response to molecule of fungal origin; positive regulation of tumor necrosis factor production; defense response to protozoan; cell-cell adhesion; positive regulation of phagocytosis; innate immune response; carbohydrate mediated signaling; inflammatory response; phagocytosis, engulfment; detection of yeast Reference #:  Q9BXN2 (UniProtKB) Alt. Names/Synonyms: Beta-glucan receptor; BGR; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; CANDF4; CLC7A; CLEC7A; CLECSF12; DC-associated C-type lectin 1; Dectin-1; DECTIN1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1 Gene Symbols: CLEC7A Molecular weight: 27,627 Da Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below dectin-1 2BPD - A/B=113-244 (mouse) 2BPE - A/B=113-244 (mouse) 2BPH - A/B=113-244 (mouse) 2CL8 - A/B=113-244 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T66	VIAVVLGTMAIWRSN
0	1		Y132-p	IIYEKSCyLFSMSLN
0	3		K157-u	QLGSNLLkIDsSNEL
0	1		S160-p	SNLLkIDsSNELGFI
0	2		K169-u	NELGFIVkQVSSQPD

	dectin-1 iso3
T66	VIAVVLGTMAIWRSN
Y132	IIYEKSCYLFSMSLN
K157	QLGSNLLKIDSSNEL
S160	SNLLKIDSSNELISD
-	gap

	dectin-1 iso9
T66-p	VIAVVLGtMAGFKAV
-	gap
-	gap
-	gap
-	gap

	mouse
-	gap
Y131	IMHGKSCYLFSFSGN
K156	QLGAHLLKIDNSKEF
N159	AHLLKIDNSKEFEFI
S168	KEFEFIESQTSSHRI

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.