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PIGB (human)

Overview PIGB Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily. Note: This description may include information from UniProtKB. Protein type: EC 2.4.1.-; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Transferase Cellular Component: intrinsic to endoplasmic reticulum membrane; endoplasmic reticulum membrane; integral to membrane Molecular Function: mannosyltransferase activity Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification Reference #:  Q92521 (UniProtKB) Alt. Names/Synonyms: GPI mannosyltransferase 3; GPI mannosyltransferase III; GPI-MT-III; MGC21236; phosphatidylinositol glycan anchor biosynthesis, class B; phosphatidylinositol glycan, class B; Phosphatidylinositol-glycan biosynthesis class B protein; PIG-B; PIGB Gene Symbols: PIGB Molecular weight: 65,056 Da Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states

Select Structure to View Below PIGB

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	10		S39-p	IKLRKRKsTLYFNTQ
0	1		I61	GDLLGENIYLLLFTI
0	1		Y62	DLLGENIYLLLFTIA
0	1		T234-p	LAFIIRPtAVILWtP
0	1		T240-p	PtAVILWtPLLFRHF
0	1		Y402-p	SNLFLALyTGLVHQR

	mouse
S29-p	MKLRRRKsRQYVSAQ
T50-p	RGLLGENtyLVLFTI
Y51-p	GLLGENtyLVLFTIA
T223	LACVVRPTALIPWVP
V229	PTALIPWVPLLFRHF
Y391	SNVPLAFYTGLVHQR

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