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RECK (human)

Overview RECK Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. Note: This description may include information from UniProtKB. Protein type: Membrane protein, anchored Cellular Component: membrane; plasma membrane Molecular Function: serine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: extracellular matrix organization and biogenesis; blood vessel maturation; embryo implantation Reference #:  O95980 (UniProtKB) Alt. Names/Synonyms: hRECK; membrane-anchored glycoprotein (metastasis and invasion); RECK; Reversion-inducing cysteine-rich protein with Kazal motifs; reversion-inducing-cysteine-rich protein with kazal motifs; ST15; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); Suppressor of tumorigenicity 15 protein Gene Symbols: RECK Molecular weight: 106,457 Da Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RECK

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		N83	ETMVEIWNCMNSSLP
0	1		Y154-p	MGSVCCSyAGHHTNC
0	1		Y164-p	HHTNCREyCQAIFRT
0	1		T843-p	FDKEKLDtIAKVtNK
0	1		T848-p	LDtIAKVtNKKPITV
0	1		T969-p	LALHLLWtyN_____
0	1		Y970-p	ALHLLWtyN______

	mouse
S83-p	ETMVEIWsCMNSSLP
Y154	MGSVCCSYAGHHTNC
F164	HHTNCREFCQAIFRT
T843	FDKEKLDTIAKVTSK
T848	LDTIAKVTSKKPITV
T969	LTVHLLWTRP_____
R970	TVHLLWTRP______

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