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Protein Page:
EphA5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EphA5 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.1.112; Membrane protein, integral; TK group; Eph family
Cellular Component: cell soma; rough endoplasmic reticulum; axon; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; plasma membrane; external side of plasma membrane
Molecular Function: transmembrane-ephrin receptor activity; GPI-linked ephrin receptor activity; ephrin receptor activity; ATP binding
Biological Process: axon guidance; cAMP-mediated signaling; peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; hippocampus development; activation of CREB transcription factor; ephrin receptor signaling pathway; neuron development; negative regulation of synaptogenesis; regulation of Rac GTPase activity
Reference #:  P54756 (UniProtKB)
Alt. Names/Synonyms: CEK7; EHK-1; EHK1; EK7; EPH homology kinase 1; Eph homology kinase-1; EPH receptor A5; EPH-like kinase 7; EPHA5; ephrin receptor EphA5; Ephrin type-A receptor 5; HEK7; receptor protein-tyrosine kinase HEK7; TYRO4; tyrosine-protein kinase receptor EHK-1
Gene Symbols: EPHA5
Molecular weight: 114,803 Da
Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states
Select Structure to View Below

EphA5

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MRGsGPRGAGR
0 1 T197-p DRVMKLNtEVRDVGP
0 2 Y295-p KCMCKAGyEEKNGtC
0 1 T301-p GyEEKNGtCQVCRPG
0 1 S313-p RPGFFKAsPHIQsCG
0 1 S318-p KAsPHIQsCGKCPPH
0 3 K387-ub PADTGGRkDVSYYIA
0 1 Y391 GGRkDVSYYIACKKC
0 3 T649-p IKLPGVRtyIDPHty
0 24 Y650-p KLPGVRtyIDPHtyE
0 2 T655-p RtyIDPHtyEDPNQA
0 27 Y656-p tyIDPHtyEDPNQAV
0 1 S673-p FAKEIEAsCItIERV
0 1 T676-p EIEAsCItIERVIGA
0 3 K710-ub PVAIKTLkVGYTEKQ
0 1 S746 LEGVVTKSKPVMIVT
0 1 S760 TEYMENGSLDTFLKK
0 1 T763 MENGSLDTFLKKNDG
0 1 Y790-p GISAGMKyLSDMGYV
0 2 S822-p KVSDFGLsRVLEDDP
1 708 Y833-p EDDPEAAyTtRGGKI
0 2 T834 DDPEAAyTtRGGKIP
0 2 T835-p DPEAAyTtRGGKIPI
0 1 T856-p AIAFRKFtSASDVWS
0 1 S873-p IVMWEVVsYGERPYW
0 1 S953-p VNASCRVsNLLAEHs
0 1 S960-p sNLLAEHsPLGsGAy
0 2 S964-p AEHsPLGsGAyRSVG
0 3 Y967-p sPLGsGAyRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
  mouse

 
S4 ____MRGSGPRGAGH
T199 DRVMKLNTEVRDVGP
Y297 KCMCKAGYEEKNGTC
T303 GYEEKNGTCQAPSPV
- gap
- gap
- gap
- gap
T488-p IKLPGVRtyIDPHty
Y489-p KLPGVRtyIDPHtyE
T494-p RtyIDPHtyEDPNQA
Y495-p tyIDPHtyEDPNQAV
S512 FAKEIEASCITIERV
T515 EIEASCITIERVIGA
K549 PVAIKTLKVGYTEKQ
S585-p LEGVVTKsKPVMIVT
S599-p TEYMENGsLDtFLKK
T602-p MENGsLDtFLKKNDG
Y629 GIAAGMKYLSDMGYV
S661-p KVSDFGLsRVLEDDP
Y672-p EDDPEAAyttRGGKI
T673-p DDPEAAyttRGGKIP
T674-p DPEAAyttRGGKIPI
T695 AIAFRKFTSSSDVWS
S712 IVMWEVVSYGERPYW
S792 VNASSRVSTLLAEHG
G799 STLLAEHGSLGSGAY
S803 AEHGSLGSGAYRSVG
Y806 GSLGSGAYRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
  rat

 
S4 ____MRGSGPRGAGR
T199 DRVMKLNTEVRDVGP
Y297 KCMCKAGYEEKNGTC
T303 GYEEKNGTCQVCRPG
S315 RPGFFKASPHSQTCS
T320 KASPHSQTCSKCPPH
K389 PADTGGGKDVSyYIL
Y393-p GGGKDVSyYILCKKC
T651 IKLPGVRTyIDPHTy
Y652-p KLPGVRTyIDPHTyE
T657 RTyIDPHTyEDPTQA
Y658-p TyIDPHTyEDPTQAV
S675 FGKEIEASCITIERV
T678 EIEASCITIERVIGA
K712 PVATKTLKVGYTEKQ
S748 LEGVVTKSKPVMIVT
S762 TEYMENGSLDTFLKK
T765 MENGSLDTFLKKNDG
Y792 GIAAGMKYLSDMGYV
S824 KVSDFGLSRVLEDDP
Y835-p EDDPEAAyTTRGGKI
T836 DDPEAAyTTRGGKIP
T837 DPEAAyTTRGGKIPI
T858 AIAFRKFTSASDVWS
S875 IVMWEVVSYGERPYW
S955 VNASSRVSTLLAEHG
G962 STLLAEHGSLGSGAY
S966 AEHGSLGSGAYRSVG
Y969 GSLGSGAYRSVGEWL
8793 : EphA3/A4/A5 (D2C11) Rabbit mAb
8862 : Phospho-EphA3 (Tyr779) (D10H1) Rabbit mAb
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