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EphA5 (human)

Overview EphA5 Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; EC 2.7.1.112; Kinase, protein; TK group; Eph family Cellular Component: cell soma; rough endoplasmic reticulum; perinuclear region of cytoplasm; axon; integral to plasma membrane; dendrite; plasma membrane; external side of plasma membrane Molecular Function: transmembrane-ephrin receptor activity; GPI-linked ephrin receptor activity; ephrin receptor activity; ATP binding Biological Process: axon guidance; cAMP-mediated signaling; regulation of actin cytoskeleton organization and biogenesis; hippocampus development; ephrin receptor signaling pathway; activation of CREB transcription factor; neuron development; regulation of Rac GTPase activity Reference #:  P54756 (UniProtKB) Alt. Names/Synonyms: CEK7; EHK-1; EHK1; EK7; EPH homology kinase 1; Eph homology kinase-1; EPH receptor A5; EPH-like kinase 7; EPHA5; ephrin receptor EphA5; Ephrin type-A receptor 5; HEK7; receptor protein-tyrosine kinase HEK7; TYRO4; tyrosine-protein kinase receptor EHK-1 Gene Symbols: EPHA5 Molecular weight: 114,803 Da Basal Isoelectric point: 6.53  Predict pI for various phosphorylation states CST Pathways:  Tyrosine Kinases

Select Structure to View Below EphA5 2R2P - A=653-939 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME 2.7.1.112 2.7.10.1  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S4-p	____MRGsGPRGAGR
0	1		T197-p	DRVMKLNtEVRDVGP
0	2		Y295-p	KCMCKAGyEEKNGtC
0	1		T301-p	GyEEKNGtCQVCRPG
0	1		S313-p	RPGFFKAsPHIQsCG
0	1		S318-p	KAsPHIQsCGKCPPH
0	3		K387-u	PADTGGRkDVSYYIA
0	1		Y391	GGRkDVSYYIACKKC
0	2		T649-p	IKLPGVRtyIDPHTy
0	23		Y650-p	KLPGVRtyIDPHTyE
0	1		T655	RtyIDPHTyEDPNQA
0	26		Y656-p	tyIDPHTyEDPNQAV
0	3		K710-u	PVAIKTLkVGYTEKQ
0	1		S746	LEGVVTKSKPVMIVT
0	1		S760	TEYMENGSLDTFLKK
0	1		T763	MENGSLDTFLKKNDG
0	1		Y790-p	GISAGMKyLSDMGYV
0	2		S822-p	KVSDFGLsRVLEDDP
0	737		Y833-p	EDDPEAAyTTRGGKI
0	1		T834	DDPEAAyTTRGGKIP
0	1		T856-p	AIAFRKFtSASDVWS
0	1		S873-p	IVMWEVVsYGERPYW
0	1		S953-p	VNASCRVsNLLAEHs
0	1		S960-p	sNLLAEHsPLGsGAy
0	2		S964-p	AEHsPLGsGAyRSVG
0	2		Y967-p	sPLGsGAyRSVGEWL

	mouse
S4	____MRGSGPRGAGH
T199	DRVMKLNTEVRDVGP
Y297	KCMCKAGYEEKNGTC
T303	GYEEKNGTCQAPSPV
-	gap
-	gap
-	gap
-	gap
T488-p	IKLPGVRtyIDPHty
Y489-p	KLPGVRtyIDPHtyE
T494-p	RtyIDPHtyEDPNQA
Y495-p	tyIDPHtyEDPNQAV
K549	PVAIKTLKVGYTEKQ
S585-p	LEGVVTKsKPVMIVT
S599-p	TEYMENGsLDtFLKK
T602-p	MENGsLDtFLKKNDG
Y629	GIAAGMKYLSDMGYV
S661-p	KVSDFGLsRVLEDDP
Y672-p	EDDPEAAytTRGGKI
T673-p	DDPEAAytTRGGKIP
T695	AIAFRKFTSSSDVWS
S712	IVMWEVVSYGERPYW
S792	VNASSRVSTLLAEHG
G799	STLLAEHGSLGSGAY
S803	AEHGSLGSGAYRSVG
Y806	GSLGSGAYRSVGEWL

	rat
S4	____MRGSGPRGAGR
T199	DRVMKLNTEVRDVGP
Y297	KCMCKAGYEEKNGTC
T303	GYEEKNGTCQVCRPG
S315	RPGFFKASPHSQTCS
T320	KASPHSQTCSKCPPH
K389	PADTGGGKDVSyYIL
Y393-p	GGGKDVSyYILCKKC
T651	IKLPGVRTyIDPHTy
Y652-p	KLPGVRTyIDPHTyE
T657	RTyIDPHTyEDPTQA
Y658-p	TyIDPHTyEDPTQAV
K712	PVATKTLKVGYTEKQ
S748	LEGVVTKSKPVMIVT
S762	TEYMENGSLDTFLKK
T765	MENGSLDTFLKKNDG
Y792	GIAAGMKYLSDMGYV
S824	KVSDFGLSRVLEDDP
Y835-p	EDDPEAAyTTRGGKI
T836	DDPEAAyTTRGGKIP
T858	AIAFRKFTSASDVWS
S875	IVMWEVVSYGERPYW
S955	VNASSRVSTLLAEHG
G962	STLLAEHGSLGSGAY
S966	AEHGSLGSGAYRSVG
Y969	GSLGSGAYRSVGEWL

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