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Protein Page:
LCMT1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LCMT1 Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - androgen and estrogen; EC 2.1.1.-; Other Amino Acids Metabolism - selenoamino acid; EC 2.1.1.233; Methyltransferase; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - histidine
Cellular Component: cytosol
Molecular Function: transferase activity; methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; protein methyltransferase activity
Biological Process: methylation; regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; negative regulation of protein complex assembly
Reference #:  A2RTH5 (UniProtKB)
Alt. Names/Synonyms: AL033290; Lcmt; LCMT-1; Lcmt1; Leucine carboxyl methyltransferase 1; Leucine carboxyl methyltransferase 1, isoform CRA_b; MGC11807
Gene Symbols: Lcmt1
Molecular weight: 38,192 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LCMT1

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 4 S8 MASSSRESSFSSCSS
0 19 S9 ASSSRESSFSSCSSS
0 3 S11 SSRESSFSSCSSSCD
0 13 S12 SRESSFSSCSSSCDL
0 1 S15 SSFSSCSSSCDLDDE
0 2 - gap
0 1 S16 SFSSCSSSCDLDDEG
0 1 Y116 EGLLPNKYFEVDFPM
0 1 K179 DLSELEEKLKKCNMN
0 13 S247-p IENLRRRsCDLAGVE
0 1 L268 SQKERLLLNGWETAS
0 1 S275 LNGWETASAVNMMEL
0 1 K328 GGQELGLKEITY___
  human

 
S8-p MATRQREssItsCCs
S9-p ATRQREssItsCCst
T11-p RQREssItsCCstSs
S12-p QREssItsCCstSsC
S15-p ssItsCCstSsCDAD
T16-p sItsCCstSsCDADD
S18-p tsCCstSsCDADDEG
Y118-p EDLLPSKyFEVDFPM
K181-ac DLSELEEkLKKCNMN
Q249 IENLRRRQCDLAGVE
S270-p SQKERLLsNGWETAs
S277-p sNGWETAsAVDMMEL
K330-ub GGNELGLkEITY___
  rat

 
S8 MATGSRESSFSSCAS
S9 ATGSRESSFSSCASS
S11 GSRESSFSSCASSCD
S12 SRESSFSSCASSCDF
S15 SSFSSCASSCDFDDE
- gap
S16 SFSSCASSCDFDDEG
Y116 EGLLPNKYFEVDFPM
K179 DLSELEEKLKKCNMN
Q247 IENLRRRQCDLAGVE
L268 SQKERLLLNGWETAS
S275 LNGWETASAVNMMEL
K328 GGQELGLKEITY___
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