Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; EC 2.1.1.-; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Methyltransferase; Lipid Metabolism - androgen and estrogen; Other Amino Acids Metabolism - selenoamino acid
Cellular Component: cytosol
Molecular Function: transferase activity; methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; protein methyltransferase activity
Biological Process: methylation; regulation of apoptosis; protein amino acid methylation; C-terminal protein amino acid methylation; negative regulation of protein complex assembly
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.