EphA4
a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; EC 2.7.1.112; TK group; Eph family
Cellular Component: postsynaptic membrane; axon; early endosome membrane; integral to plasma membrane; postsynaptic density; dendrite; cytoplasm; neuromuscular junction; cell junction
Molecular Function: protein binding; transmembrane-ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; PH domain binding; ATP binding; protein kinase activity
Biological Process: positive regulation of JNK activity; regulation of Rap GTPase activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; corticospinal tract morphogenesis; regulation of axonogenesis; cell adhesion; regulation of Rac GTPase activity; adult walking behavior
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.
