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ZBTB17
May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation. Belongs to the krueppel C2H2-type zinc-finger protein family. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein; C2H2-type zinc finger protein |
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Cellular Component: nucleoplasm
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Molecular Function: protein binding; DNA binding; zinc ion binding; transcription factor activity
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Biological Process: unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; ectoderm development; gastrulation with mouth forming second; negative regulation of cell cycle
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Reference #:
Q13105 (UniProtKB)
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| Alt. Names/Synonyms: Miz-1; MIZ1; Myc-interacting zinc finger protein 1; Myc-interacting Zn finger protein-1; pHZ-67; ZBT17; ZBTB17; zinc finger and BTB domain containing 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; zinc finger protein 151 (pHZ-67); Zinc finger protein 60; ZNF151; ZNF60 |
| Gene Symbols: ZBTB17 |
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Molecular weight: 87,928 Da
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Basal Isoelectric point: 6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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