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Protein Page:
ZBTB17 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZBTB17 May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation. Belongs to the krueppel C2H2-type zinc-finger protein family. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; C2H2-type zinc finger protein
Cellular Component: nucleoplasm
Molecular Function: protein binding; DNA binding; metal ion binding; transcription factor activity
Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; ectoderm development; gastrulation with mouth forming second; negative regulation of cell cycle
Reference #:  Q13105 (UniProtKB)
Alt. Names/Synonyms: Miz-1; MIZ1; Myc-interacting zinc finger protein 1; Myc-interacting Zn finger protein-1; pHZ-67; ZBT17; ZBTB17; zinc finger and BTB domain containing 17; Zinc finger and BTB domain-containing protein 17; Zinc finger protein 151; zinc finger protein 151 (pHZ-67); Zinc finger protein 60; ZNF151; ZNF60
Gene Symbols: ZBTB17
Molecular weight: 87,928 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZBTB17

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S120-p SLAEPATsPGGNAEA
0 1 K135-ub LATEGGDkRAKEEKV
0 4 S156-p RLEQAGRstPIGPsR
0 7 T157-p LEQAGRstPIGPsRD
0 1 S162-p RstPIGPsRDLKEER
0 1 S175-p ERGGQAQsAAsGAEQ
1 1 S178-p GQAQsAAsGAEQTEK
0 1 S271-p EENENEEsAGtDSGQ
0 1 T274-p ENEEsAGtDSGQELG
0 1 T291-p ARGLRSGtyGDRTES
0 1 Y292-p RGLRSGtyGDRTESK
0 1 K332-ub IRIHTGEkPFSCREC
0 1 K341-ub FSCRECSkAFSDPAA
0 1 K350-ub FSDPAACkAHEKtHs
0 1 T355-p ACkAHEKtHsPLKPy
0 1 S357-p kAHEKtHsPLKPyGC
0 1 Y362-p tHsPLKPyGCEECGK
0 1 Y371-p CEECGKSyRLISLLN
0 1 K433-ac SFSDPTSkMRHLETH
0 1 S570-p CGKRFVQsSQLANHI
0 1 T609-p SKHIIIHtGEKPYLC
  mouse

 
T120 SLAEPSSTTGESADA
K135 SAVEGGDKRAKDEKA
S156 RLDQARGSSSTGPGR
S157 LDQARGSSSTGPGRE
G162 GSSSTGPGRELKEER
S175 ERGGQAESASsGAEQ
S178-p GQAESASsGAEQTEK
S262 PPEENEESAGTDSGQ
T265 ENEESAGTDSGQELG
T282 GQNLRSGTYGDRTES
Y283 QNLRSGTYGDRTESK
K323 IRIHTGEKPFSCREC
K332 FSCRECSKAFSDPAA
K341 FSDPAACKAHEKTHS
T346 ACKAHEKTHSPLKPY
S348 KAHEKTHSPLKPYGC
Y353 THSPLKPYGCEECGK
Y362 CEECGKSYRLISLLN
K424 SFSDPTSKMRHLETH
S561 CGKRFVQSSQLANHI
T600 SKHIIIHTGEKPYLC
  rat

 
T120 SLAEPTSTTGESADA
K142 VLSPGGDKRAKEEKA
S163 RLDQARSSSSAGPGR
S164 LDQARSSSSAGPGRE
G169 SSSSAGPGRELKEEW
S182 EWGGQAESASRGAEQ
R185 GQAESASRGAEQTEK
S269 PPEENEESAGTDSGH
T272 ENEESAGTDSGHELG
T289 GQNLRSGTYGDRTES
Y290 QNLRSGTYGDRTESK
K330 IRIHTGEKPFSCREC
K339 FSCRECSKAFSDPAA
K348 FSDPAACKAHEKTHS
T353 ACKAHEKTHSPLKPY
S355 KAHEKTHSPLKPYGC
Y360 THSPLKPYGCEECGK
Y369 CEECGKSYRLISLLN
K431 SFSDPTSKMRHLETH
S568 CGKRFVQSSQLANHI
T607 SKHIIIHTGEKPYLC
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