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Protein Page:
MAOA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAOA Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - histidine; Membrane protein, integral; Amino Acid Metabolism - arginine and proline; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - glycine, serine and threonine
Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane
Molecular Function: amine oxidase activity
Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; neurotransmitter secretion; xenobiotic metabolic process; neurotransmitter biosynthetic process
Reference #:  P21397 (UniProtKB)
Alt. Names/Synonyms: Amine oxidase [flavin-containing] A; AOFA; MAO-A; MAOA; monoamine oxidase A; Monoamine oxidase type A
Gene Symbols: MAOA
Molecular weight: 59,682 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
Select Structure to View Below

MAOA

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S209‑p
protein conformation: S209‑p
protein degradation: S209‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T52-p RDRVGGRtyTIRNEH
0 15 Y53-p DRVGGRtyTIRNEHV
0 1 D61 TIRNEHVDYVDVGGA
0 2 D61 TIRNEHVDYVDVGGA
0 1 K82 NRILRLSKELGIETY
0 1 K90 ELGIETYKVNVSERL
0 1 K136-ac RTIDNMGkEIPTDAP
0 1 K136 RTIDNMGKEIPTDAP
2 0 S209-p GGTTRIFsVTNGGQE
0 1 Y268-p HEHYECKyVINAIPP
0 1 R284 LTAKIHFRPELPAER
0 1 S345-p DDTKPDGsLPAIMGF
0 1 K372 HKEIRKKKICELYAK
0 4 S383-p LYAKVLGsQEALHPV
0 3 H388 LGsQEALHPVHYEEK
0 1 Y392 EALHPVHYEEKNWCE
0 7 K469-ub GLGKVTEkDIWVQEP
0 1 K479 WVQEPESKDVPAVEI
  mouse

 
T52 RDRVGGRTYTVRNEH
Y53 DRVGGRTYTVRNEHV
K61-ac TVRNEHVkWVDVGGA
K61-ub TVRNEHVkWVDVGGA
K82-ub NRILRLSkELGIETY
K90-ub ELGIETYkVNVNERL
K136 RTMDDMGKEIPVDAP
K136-ub RTMDDMGkEIPVDAP
S209 GGTSRIFSVTNGGQE
Y268 HEHYECKYVISAIPP
K284 LTAKIHFKPELPPER
S345 DDTKPDGSMPAIMGF
K372-ub HKDIRKRkICELYAK
S383-p LYAKVLGsQEALsPV
S388-p LGsQEALsPVHyEEK
Y392-p EALsPVHyEEKNWCE
K469-ub ALGKVAKkDIWVQEP
K479-ub WVQEPESkDVPALEI
  rat

 
T52 RDRVGGRTYTVRNEH
Y53 DRVGGRTYTVRNEHV
K61 TVRNEHVKWVDVGGA
K61 TVRNEHVKWVDVGGA
K82 NRILRLSKELGIETY
K90 ELGIETYKVNVNERL
K136 RTMDEMGKEIPVDAP
K136 RTMDEMGKEIPVDAP
S209 GGTARIFSVTNGGQE
Y268 HEHYECKYVISAIPP
K284-ub LTAKIHFkPELPPER
S345 DDTKPDGSLPAIMGF
K372 HKDIRKRKICELYAK
S383 LYAKVLGSQEALYPV
Y388 LGSQEALYPVHYEEK
Y392 EALYPVHYEEKNWCE
K469 ALGKVAKKDIWVEEP
K479 WVEEPESKDVPAIEI
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