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MAOA
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - tyrosine; Oxidoreductase; EC 1.4.3.4 |
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Cellular Component: mitochondrial outer membrane; integral to membrane
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Molecular Function: amine oxidase activity; serotonin binding; FAD binding
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Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; behavior; neurotransmitter secretion; xenobiotic metabolic process; phenylethylamine metabolic process; serotonin metabolic process; neurotransmitter biosynthetic process
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Reference #:
P21397 (UniProtKB)
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| Alt. Names/Synonyms: Amine oxidase [flavin-containing] A; AOFA; MAO-A; MAOA; monoamine oxidase A; Monoamine oxidase type A |
| Gene Symbols: MAOA |
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Molecular weight: 59,682 Da
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Basal Isoelectric point: 7.94
Predict pI for various phosphorylation states
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